摘要： 缺血-再灌注损伤是组织或器官在缺血损伤发生后，由于恢复供血供氧使原有器官组织损伤加重的过程。常见于急性冠脉综合征、休克、脑卒中、急性肾损伤、体外循环手术与器官移植等。缺血-再灌注损伤参与多种病理机制，其在分子层面发生发展的机制尚不十分清楚。环状RNA是一类具有特殊共价环结构的RNA，越来越多的研究证明环状RNA参与缺血-再灌注损伤的发生和发展。本文对环状RNA在缺血-再灌注损伤中的研究进展进行综述。

环状RNA在缺血-再灌注损伤中的研究进展

李丽, 栾军军, 周华

中国医科大学附属盛京医院肾内科, 沈阳 110004

收稿日期:2021-09-13出版日期:2022-09-30发布日期:2022-09-03
通讯作者:周华E-mail:huazhou_cmu@163.com
作者简介:李丽（1984-），女，讲师，硕士.
基金资助:国家自然科学基金（81770698，82170740，82100743）；国家重点研发计划（2017YFC0907400）；辽宁省兴辽英才计划（XLYC2002081）；辽宁省重点研发指导计划（2019JH8/10300009）


关键词: 环状RNA, 缺血-再灌注损伤, 自噬, 凋亡, 焦亡
Abstract: Ischemia/reperfusion injury causes various organ tissue damage. The reperfusion of blood flow restores oxygen supply and is currently recognized in ischemic tissues or organs that are commonly affected in coronary heart disease, shock, stroke, acute kidney injury, cardiopulmonary bypass, and organ transplantation. Circular RNA, a novel class of non-coding RNA, is involved in the pathogenesis of various diseases. However, the molecular mechanisms of ischemia/reperfusion-induced acute tissue injury and the damage chronicity still remain unclear. In this review, we summarize the published research articles related to circular RNAs in ischemia/reperfusion-induced injury and highlight the novel molecular mechanisms of circular RNAs in its onset and progression.
Key words: circular RNA, ischemia/reperfusion injury, autophagy, apoptosis, pyroptosis
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