摘要： 目的 探讨血清钠离子水平与心力衰竭(简称心衰) 患者发生院内死亡的关系, 并进一步分析低钠血症对射血分数减低心衰(HFrEF) 患者发生院内死亡的影响。方法 收集中国医科大学盛京医院心内科2013年1月至2018年12月心衰患者的住院资料, 采用SPSS 22.0软件, 应用独立样本t检验、χ²检验及logistic分析观察血清钠离子对心衰患者发生院内死亡的影响。结果 我院心衰患者院内死亡率为3.3%, 院内死亡组低钠血症发生率为31%, 远远大于生存组(11.4%)。多因素logistic分析结果显示, 血清钠离子是患者院内死亡的独立危险因素(OR=0.964,95%CI:0.932~0.998), 进一步分析结果显示, 血钠水平越低院内死亡率及风险比越高。结论 血清钠离子是HFrEF院内死亡的独立危险因素, 低钠血症显著增加HFrEF患者院内死亡风险。

低钠血症对心力衰竭患者院内死亡的影响

何微, 王传合, 谢嘉怡, 孙志军

中国医科大学附属盛京医院心内科, 沈阳 110004

收稿日期:2021-12-28出版日期:2022-08-30发布日期:2022-07-19
通讯作者:孙志军E-mail:sunzj@sj-hospital.org
作者简介:何微（1980-），女，护师，本科.
基金资助:辽宁省重点研发计划指导计划（2018225003）


关键词: 心力衰竭, 低钠血症, 院内死亡
Abstract: Objective To investigate the relationship between serum sodium levels and in-hospital mortality among patients with heart failure and further analyze the effect of hyponatremia on in-hospital mortality among patients suffering from heart failure with reduced ejection fraction(HFrEF). Methods We collected the data of patients hospitalized for heart failure in the Department of Cardiology, Shengjing Hospital of China Medical University, from January 2013 to December 2018, and established a retrospective cohort study database. SPSS 22.0 software was used for statistical analysis. Independent sample t test, χ² test and logistic analysis were used to classify the effects of different serum potassium levels on in-hospital mortality among these patients. Results The in-hospital mortality rate of the patients with acute decompensation of chronic heart failure was 3.3%. The incidence of hyponatremia in the in-hospital mortality group was 31%, which was much higher than that in the "survivors" group(11.4%). Multivariate logistic analysis showed that low serum sodium level was an independent risk factor for in-hospital death in patients with HFrEF(OR=0.964 and 95%CI:0.932-0.998). Further analyses showed that the lower the blood sodium level, the higher the in-hospital mortality and risk ratio. Conclusion Serum sodium ion is an independent risk factor for in-hospital mortality in HFrEF patients, and hyponatremia significantly increases the risk of in-hospital mortality among HFrEF patients.
Key words: heart failure, hyponatremia, in-hospital mortality
PDF全文下载地址:

https://journal.cmu.edu.cn/CN/article/downloadArticleFile.do?attachType=PDF&id=3048