摘要： 目的 探讨宫颈癌患者术前外周血炎症指标与临床病理特征的相关性。方法 回顾性收集行手术治疗的439例宫颈癌患者的临床资料,分析术前外周血中性粒细胞(NE)、淋巴细胞(L)、单核细胞(M)、血小板(PLT)、嗜酸细胞(E)、纤维蛋白原(FIB)、白蛋白(Alb)水平以及中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)、淋巴细胞与单核细胞比值(LMR)、嗜酸细胞与淋巴细胞比值(ELR)、嗜酸细胞与血小板比值(EPR)、系统免疫炎症指数(SII)、纤维蛋白原与白蛋白比值(FAR)和宫颈癌临床病理特征的关系。结果 与低FAR、低EPR、低FIB组比较,高FAR、高EPR、高FIB组间质浸润深度>1/2肌层患者比例高且ⅠA期患者比例低(P<0.05);高EPR组Ⅲ期患者比例高于低EPR组(P<0.05);高FIB组ⅡA期患者比例高于低FIB组(P<0.05)。高SII、高NE、高PLT组肿瘤病灶≥ 4 cm患者比例高于低SII、低NE、低PLT组(P<0.05)。高M、高E组伴有淋巴转移患者比例高于低M、低E组(P<0.05)。与低PLR组比较,高PLR组中分化患者比例低(P<0.05),而低分化患者比例高(P<0.05)。NLR、LMR、ELR、L、Alb水平在宫颈癌临床分期、间质浸润深度、肿瘤病灶大小、淋巴转移、分化程度、病理类型和脉管浸润方面的差异均无统计学意义(P>0.05)。结论 术前外周血NE、PLT、M、E、FIB水平以及FAR、EPR、SII、PLR与宫颈癌的临床病理特征有关,为术前评估宫颈癌患者病情提供重要依据。

外周血炎症指标与宫颈癌临床病理特征的相关性

孙小凡, 刘贵朋

中国医科大学附属盛京医院妇产科, 沈阳 110004

收稿日期:2021-09-01出版日期:2022-07-30发布日期:2022-06-27
通讯作者:刘贵朋E-mail:liugp@sj-hospital.org
作者简介:孙小凡(1995-),女,医师,硕士.
基金资助:中国医科大学附属盛京医院院内一般项目(M0797)


关键词: 宫颈癌, 炎症指标, 临床病理特征
Abstract: Objective To investigate the relationship between preoperative peripheral blood inflammatory indicators and clinicopathological features of patients with cervical cancer. Methods A total of 439 patients with cervical cancer who underwent surgery were selected. The clinical data were collected,and the relationship between the clinicopathological features of cervical cancer and the preoperative peripheral blood levels of neutrophil (NE),lymphocyte (L),monocyte (M),platelet (PLT),eosinophil (E),fibrinogen (FIB),and albumin (Alb),neutrophil-to-lymphocyte ratio (NLR),platelet-to-lymphocyte ratio (PLR),lymphocyte-to-monocyte ratio (LMR),eosinophil-to-lymphocyte ratio (ELR),eosinophil-to-platelet ratio (EPR),fibrinogen-to-albumin (FAR) ratio,and systemic immune inflammatory index (SII) was analyzed. Results The preoperative peripheral blood levels of NE and PLT were associated with tumor size (P< 0.05), while those of M and E were associated with lymphatic metastasis (P< 0.05). The preoperative peripheral blood levels of FIB,FAR,and EPR were associated with interstitial infiltration depth and clinical stage (P< 0.05). SII was associated with tumor size (P< 0.05). PLR was associated with differentiation degree (P< 0.05). NLR,LMR,ELR,and the preoperative peripheral blood levels of L and Alb were not correlated with clinical stage,interstitial infiltration depth,tumor size,differentiation degree,pathological type,lymphatic metastasis, and vascular infiltration (all P> 0.05). Conclusion The preoperative peripheral blood levels of NE,PLT,M,and E,and FIB,FAR, EPR,SII,and PLR were associated with the clinicopathological features of patients with cervical cancer and can be used to assess disease severity before surgery.
Key words: cervical cancer, inflammatory indicator, clinicopathological feature
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