摘要： 肥胖是由于能量摄入长期超过能量消耗所致。传统治疗肥胖的方法并不能为大多数患者提供满意的长期疗效。在成人功能性棕色脂肪组织被证实存在后,研究者致力于开发基于脂肪组织本身的治疗方式,将积累脂肪的白色脂肪组织转化为耗能的棕色脂肪组织。目前,利用内源性、药理和营养等因素推动这种转化从而治疗肥胖备受关注。本文将对促进脂肪组织由白色脂肪转化为棕色脂肪进而促进产热的相关因素及其机制的最新研究进展进行综述。

脂肪组织棕色化及产热相关机制的研究进展

徐樱溪, 孔瑞琴, 孔娟

中国医科大学附属盛京医院临床营养科, 沈阳 110004

收稿日期:2021-08-23出版日期:2022-07-30发布日期:2022-06-27
通讯作者:孔娟E-mail:kongj1@sj-hospital.org
作者简介:徐樱溪(1987-),女,主治医师,博士.
基金资助:国家自然科学基金(82073545);辽宁省自然科学基金(2021-MS-208);盛京医院345人才计划(M0406);盛京医院院内一般项目(M0791)


关键词: 棕色脂肪, 白色脂肪, 能量代谢, 产热
Abstract: Obesity is caused by long-term energy intake that exceeds energy expenditure. Traditional methods of treating obesity do not provide satisfactory outcomes. Following the confirmation of functional brown adipose tissue in adults,research efforts are focusing on developing a treatment based on the adipose tissue,by converting the white adipose tissue that accumulates fat into brown adipose tissue that consumes energy. At present,the application of endogenous,pharmacological,and nutritional factors to promote this transformation to treat obesity has been attracting more attention. In this review,we provide an overview of the factors and mechanisms that promote the conversion of white adipose tissue to brown adipose tissue,thus promoting thermogenesis.
Key words: brown adipose tissue, white adipose tissue, energy metabolism, thermogenesis
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