摘要： 目的 探讨宫颈癌治疗前后人乳头状瘤病毒（HPV）感染的变化和临床特征及其与预后的关系。方法 选择2014年1月至2015年12月于我院行HPV和石蜡病理检查并进行手术或根治性放化疗的宫颈癌患者，分析宫颈癌治疗前后HPV感染的变化、患者年龄、FIGO分期、病理类型、分化程度、淋巴结转移与宫颈癌预后的关系。结果 共纳入114例宫颈癌患者，患者平均年龄（48.1±9.6）岁。宫颈癌治疗前HPV感染情况、患者年龄与预后无相关性（P > 0.05）；宫颈癌治疗后HPV感染情况、FIGO分期、病理类型、分化程度、淋巴结转移与预后密切相关（P < 0.01）。宫颈癌治疗后HPV感染情况、病理类型与淋巴结转移无相关性（P > 0.05），分化程度与淋巴结转移密切相关（χ²=8.246，P=0.016）。logistic回归分析结果表明，宫颈癌治疗后HPV感染情况、淋巴结转移、FIGO分期与宫颈癌复发密切相关。结论 高度重视宫颈癌治疗后HPV的检测和预防，治疗时注意宫颈癌FIGO分期和淋巴结转移情况，尽早治疗和预防宫颈癌复发，可提高患者生存期和生存质量。

宫颈癌治疗前后人乳头状瘤病毒感染的变化和临床特征及其与预后的关系

苏有博¹, 魏恒²

1. 中国医科大学附属盛京医院院长办公室, 沈阳 110004;
2. 中国医科大学附属盛京医院妇产科, 沈阳 110004

收稿日期:2021-05-21出版日期:2022-04-20发布日期:2022-05-05
通讯作者:魏恒E-mail:weiheng-1986@163.com
作者简介:苏有博(1987-),男,硕士研究生.



关键词: 人乳头状瘤病毒感染, FIGO分期, 淋巴结转移, 鳞状细胞癌, 腺癌
Abstract: Objective To investigate the changes in human papilloma virus (HPV) infection before and after treatment and clinical characteristics and their relationship with prognosis in patients with cervical cancer. Methods Patients with cervical cancer who underwent surgery or radical radiotherapy at our hospital from January 2014 to December 2015 were included and received HPV examination and paraffin pathological examination. The correlation of changes in HPV infection before and after treatment,age,FIGO stage,pathological type,degree of differentiation,and lymph node metastasis with prognosis of cervical cancer were analyzed. Results A total of 114 patients with cervical cancer were included. The average age of the patients was 48.1±9.6 years. There was no correlation between HPV types before treatment and age and prognosis of cervical cancer (P > 0.05). HPV types after treatment,FIGO stage,pathological type,degree of differentiation,and lymph node metastasis were significantly related to the prognosis of cervical cancer (P < 0.01). There was no correlation between HPV types after treatment and pathological type and lymph node metastasis of cervical cancer (P > 0.05). The degree of differentiation was significantly related to lymph node metastasis (χ²=8.246,P=0.016). Logistic regression analysis showed that HPV types after treatment,lymph node metastasis,and FIGO stage were closely associated with cervical cancer recurrence. Conclusion Paying close attention to HPV detection and prevention after treatment and to the FIGO stage and lymph node metastasis during treatment,and early treatment and prevention can improve the survival rate and quality of life of cervical cancer patients.
Key words: human papilloma virus infection, FIGO stage, lymph node metastasis, squamous cell carcinoma, adenocarcinoma
PDF全文下载地址:

https://journal.cmu.edu.cn/CN/article/downloadArticleFile.do?attachType=PDF&id=2974