摘要： 解旋酶是核酸代谢所必需的酶，普遍存在于生物体内。Pif1是5’-3’方向ATP依赖的超家族ⅠB类解旋酶，几乎存在于所有真核生物中。Pif1不同程度地影响端粒、线粒体DNA的复制和冈崎片段的成熟。此外，Pif1可通过破坏稳定的核蛋白复合物来影响这些过程。基于Pif1对维持基因组稳定性的重要性，为肿瘤相关疾病提供新的潜在治疗方向。本文论述了Pif1维持基因组稳定性在肿瘤中所发挥的作用。

Pif1维持基因组稳定性在肿瘤中发挥的作用

陈波, 李志杰

中国医科大学附属盛京医院医学研究中心, 辽宁省环境与代谢疾病动物模型研究与应用重点实验室, 沈阳 110004

收稿日期:2021-06-16出版日期:2022-04-20发布日期:2022-05-05
通讯作者:李志杰E-mail:lizhijie68@hotmail.com
作者简介:陈波(1993-),男,硕士研究生.
基金资助:国家自然科学基金 （81472359，81972515）


关键词: Pif1, 解旋酶, 基因组稳定性, 复制, 肿瘤
Abstract: Helicase is necessary for enzymes involved in nucleic acid metabolism in a variety of organisms. Pif1 is an ATP-dependent superfamily ⅠB class of helicases that work in the 5' to 3' direction and is found in almost all eukaryotes. Pif1 affects telomere,mitochondrial DNA replication,and Okazaki fragment maturation to varying degrees,such as through the disruption of stable nuclear protein complexes. Based on the importance of Pif1 in maintaining genomic stability,these current findings also offer new potential therapeutic directions for tumor-related diseases. This paper reviews the role of Pif1 in maintaining genomic stability in tumors.
Key words: Pif1, helicase, genome stability, replication, tumor
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