摘要： 重度抑郁症是高度异质性的精神疾病，具有复杂的病理生理，发病机制尚不明确。遗传倾向、环境因素以及生物系统在重度抑郁症的发病中起作用。肠道菌群作为胃肠道生态系统共生的微生物，可通过肠-脑轴双向交流信息系统与宿主相互作用。肠道菌群失调可能与重度抑郁症的发病相关。本文就肠道菌群与重度抑郁症的关系及在重度抑郁症治疗中作用研究进展做一综述。

重度抑郁症与肠道菌群关系的研究进展

王冬, 汤艳清

中国医科大学附属第一医院精神医学科, 沈阳 110001

收稿日期:2021-05-26出版日期:2022-03-30发布日期:2022-03-16
通讯作者:汤艳清E-mail:tangyanqing@cmu.edu.cn
作者简介:王冬(1987-),男,医师,硕士.
基金资助:国家重点研发计划（2018YFC1311600）


关键词: 重度抑郁症, 肠道菌群, 肠-脑轴
Abstract: Major depressive disorder(MDD) is a highly heterogeneous disease with complex pathophysiology and unclear pathogenesis. Genetic predisposition, environmental factors, and biological systems all play a role in the pathogenesis of MDD. The gut microbiota refers to the large number of microorganisms co-inhabiting the gastrointestinal ecosystem. The gut microbiota can interact with the host through the gut-brain axis, a two-way communication information system. Imbalance of the gut microbiota may be associated with the onset of MDD. This article reviews the role of gut microbiota in the development of MDD and new treatment methods.
Key words: major depressive disorder, gut microbiota, gut-brain axis
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