摘要： 目的 评价中性粒细胞与淋巴细胞比值（NLR）在支气管扩张症中的应用价值。方法 回顾性分析中国医科大学附属盛京医院呼吸科2019年1月至12月住院治疗的154例支气管扩张症患者的临床资料。根据血气分析结果将患者分为呼吸衰竭组和非呼吸衰竭组，比较2组性别、年龄、吸烟史、住院天数及白细胞（WBC）计数、NLR、C反应蛋白（CRP）、降钙素原（PCT）的差异。通过受试者操作特征（ROC）曲线和曲线下面积（AUC）评价NLR和PCT、CRP在支气管扩张症诊断中的临床价值。结果 呼吸衰竭组NLR、CRP及PCT水平均高于非呼吸衰竭组（P < 0.05），2组WBC计数比较无统计学差异（P > 0.05）。NLR、CRP及PCT在预测支气管扩张症合并呼吸衰竭中有一定意义，且NLR的预测意义优于CRP、PCT，AUC为0.705，灵敏度为0.848，特异度为0.565，Cutoff值为3.700。结论 NLR对预测支气管扩张症合并呼吸衰竭的预后有一定价值。

中性粒细胞与淋巴细胞比值在支气管扩张症诊断中的应用价值

刘雪健, 王佳贺

中国医科大学附属盛京医院第一内科综合病房, 沈阳 110134

收稿日期:2021-09-27出版日期:2022-02-28发布日期:2022-01-05
通讯作者:王佳贺E-mail:wangjh@sj-hospital.org
作者简介:刘雪健(1991-),男,医师,硕士.
基金资助:国家重点研发计划（2018YFC2002104）


关键词: 支气管扩张症, 中性粒细胞与淋巴细胞比值, C反应蛋白, 降钙素原, 呼吸衰竭
Abstract: Objective To evaluate the role of the neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of bronchiectasis. Methods A retrospective analysis of 154 patients with bronchiectasis who were hospitalized in the Department of Respiration, Shengjing Hospital of China Medical University from January 2019 to December 2019 was performed. The patients were divided into respiratory failure and non-respiratory failure groups according to their blood gas analysis results. Differences in sex, age, smoking history, length of hospitalization, white blood cell (WBC) count, NLR, and C-reactive protein (CRP) and procalcitonin (PCT) levels were compared between the two groups. The NLR and PCT and CRP levels in patients with bronchiectasis were evaluated using the receiver operating characteristic curve and area under the curve (AUC). Results The NLR, PCT and CRP levels were higher in the respiratory failure group than in the non-respiratory failure group (P < 0.05), with no significant difference in the WBC count between the groups (P > 0.05). The NLR and PCT and CRP levels have certain significance in predicting bronchiectasis with respiratory failure, but the NLR had better predictive significance than CRP and PCT levels. The AUC of NLR was 0.705, and the sensitivity and specificity were 0.848 and 0.565, respectively;the cutoff value was 3.700. Conclusion NLR has certain predictive value in the prognosis of bronchiectasis with respiratory failure.
Key words: bronchiectasis, neutrophil-to-lymphocyte ratio, C-reactive protein, procalcitonin, respiratory failure
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