摘要： 目的 探讨湖南地区高血压患者尿酸（UA）与H型高血压（HHT）的关系，为HHT的社区预防提供科学依据。方法 于2013年至2014年采用随机整群抽样的方法调查湖南省6个地区高血压患者的资料，主要包括同型半胱氨酸（hcy）、UA、总胆固醇（TC）和甘油三酯（TG）等。将研究对象按照UA水平分为4组。A组为UA≤252.00 μmol/L （对照），B组为UA 252.00~316.50 μmol/L，C组为UA>316.50~376.25 μmol/L，D组为UA>376.25 μmol/L。比较不同Hcy和不同UA分组下研究对象的基线资料，基于年龄的分层采用logistic回归分析法分析UA与HHT的相关性。结果 本研究共纳入1 538例高血压患者，HHT患者占85.24%。单因素分析结果显示，HHT与普通高血压间年龄、性别、吸烟、UA、肌酐（Cr）、TG、载脂蛋白B （ApoB）、C反应蛋白（CRP）、空腹血糖（FBG）等指标的差异有统计学意义；不同UA分组中性别、吸烟、饮酒、尿素氮（BUN）、Cr、TG、TC、高密度脂蛋白（HDL-C）、载脂蛋白A （ApoA）、ApoB、FBG、Hcy的差异均有统计学意义（均P < 0.05）。logistic回归分析结果显示，UA与HHT的调整后OR分别为1.048、1.266和1.707；年龄分层后，与<60岁中A组相比，≥60岁组中UA的不同四分位水平组与HHT的OR分别为1.465、4.659、2.052和4.278。结论 UA与HHT呈正相关，这种相关性在≥60岁的高血压患者中更明显。

尿酸与H型高血压的相关性研究

谢容^1,2,3,4, 牛晓娜^1,2,3,4, 张妍楠^1,2,3,4, 杜诗虹^1,2,3,4, 杨一^1,2,3,4, 洪秀琴^1,2,3,4

1. 湖南师范大学附属第一医院临床流行病学研究室, 长沙 410005;
2. 湖南师范大学分子流行病学重点实验室, 长沙 410205;
3. 湖南省人民医院科研部, 长沙 410005;
4. 湖南师范大学转化医学研究所流行病学研究室, 长沙 410005

收稿日期:2021-04-01出版日期:2022-02-28发布日期:2022-01-05
通讯作者:洪秀琴E-mail:xiuqinhong0528@hunnu.edu.cn
作者简介:谢容(1996-),女,硕士研究生.
基金资助:国家自然科学基金（8177120863）


关键词: H型高血压, 尿酸, 年龄, 交互作用, 横断面研究
Abstract: Objective To investigate the relationship between uric acid (UA) and H-type hypertension (HHT) in Hunan Province and provide scientific evidence for the community prevention of H-type hypertension. Methods A random cluster sampling method was used to investigate the data of patients with hypertension in six regions of Hunan Province from 2013 to 2014. Baseline data mainly included homocysteine (Hcy), UA, total cholesterol (TC), and triglyceride (TG). The study participants were divided into four groups according to the UA concentration:A: ≤ 252.00 μmol/L (reference), B:>252.00-316.50 μmol/L, C:>316.50-376.25 μmol/L, and D:>376.25 μmol/L. The baseline data of the study participants were compared between different Hcy and UA groups. After age-based stratification, logistic regression analysis was used to determine the correlation between UA levels and HHT. Results This study included 1 538 hypertensive patients with an average age of 59 years, of which 85.24% were HHT patients. There were significant differences in age, sex, smoking, UA, creatinine (Cr), TG, apolipoprotein B (ApoB), C-reactive protein (CRP), and fasting blood glucose (FBG) between ordinary hypertension and HHT. The differences in sex, smoking, drinking, blood urea nitrogen (BUN), Cr, TG, TC, low density lipoprotein (HDL-C), apolipoprotein A (ApoA), ApoB, FBG, and Hcy in the different UA groups were significant (all P < 0.05). Adjusted odds ratios for the association of UA and HHT were 1.048, 1.266, and 1.707 after age stratification, comparing with the first UA group among patients < 60 years old. Adjusted odds ratios for the association of the different quartiles of UA and HHT were 1.465, 4.659, 2.052 and 4.278 in the four groups among participants ≥ 60 years old. Conclusion Uric acid was associated with H-type hypertension, and this association was more obvious in hypertensive patients ≥ 60 years of age.
Key words: H-type hypertension, uric acid, age, interaction, cross-sectional study
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