摘要： 目的 探讨我院耐碳青霉烯鲍曼不动杆菌（CRAB）感染的流行病学特征。方法 收集我院2016年1月至2019年12月CRAB感染患者的临床资料，对CRAB的检出情况、标本来源、病区分布等进行统计分析。结果 共分离出CRAB 386株，CRAB在临床分离的致病菌株中所占比例逐年上升；易感人群主要为中老年人；标本来源以呼吸道标本（痰液和肺泡灌洗液）为主，呼吸重症监护室和重症监护室检出率最高，分别为30.89%和23.98%。CRAB感染患者的死亡率为38.42%，显著高于碳青霉烯敏感鲍曼不动杆菌（CSAB）感染患者（21.64%，P < 0.05）。结论 CRAB是医院内感染的重要病原菌，临床检出率呈上升趋势，主要涉及重症监护室，尤其是呼吸重症监护室。院感防控工作应关注易感人群及重点科室，有效遏制医院内感染的爆发和蔓延。

耐碳青霉烯鲍曼不动杆菌感染的流行病学研究

李惠萍¹, 李冰¹, 刘培¹, 许兰¹, 翁选雯¹, 王博², 金源², 胡安民²

南方科技大学第一附属医院, 深圳市人民医院 1. 呼吸与危重症医学科;
2. 麻醉科, 广东 深圳 518020

收稿日期:2021-05-13出版日期:2021-11-30发布日期:2021-11-04
通讯作者:胡安民E-mail:eanmin@163.com
作者简介:李惠萍(1975-),女,副主任医师,博士.
基金资助:广东省医学科研基金（A2021058）


关键词: 耐碳青霉烯鲍曼不动杆菌, 流行病学, 医院内感染
Abstract: Objective To explore the epidemiological characteristics of carbapenem-resistant Acinetobacter baumannii (CRAB) in our hospital. Methods The clinical data of CRAB in our hospital from 2016 to 2019 were collected, and the results of CRAB detection, specimen source, and department distribution were analyzed. Results A total of 386 strains of CRAB were detected, and the proportion of CRAB in pathogenic bacteria isolated in clinical practice increased gradually over time. The majority of CRAB infections occurred in elderly patients; the patients involved were mainly in the respiratory intensive care unit (30.89%) and the general intensive care unit (23.98%). The main site of CRAB infection was the respiratory system. The mortality rate in the patients infected with CRAB was 38.42%, which was significantly higher than that in the patients infected with carbapenems-susceptible Acinetobacter baumannii (CSAB) (21.64%, P < 0.05). Conclusion The rates of isolation and infection of CRAB are gradually increasing, and CRAB has become one of the main pathogens that causes nosocomial infections. The mortality rate due to CRAB infection was much higher than that due to CSAB infection; therefore, to protect the susceptible population in the ICU, measures should be taken to control CRAB infections and prevent outbreaks.
Key words: carbapenems-resistant Acinetobacter baumanii, epidemiology, nosocomial infection
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