摘要： 目的 研究高危型人乳头瘤病毒（HR-HPV）感染与阴道菌群异常的相关性，探讨阴道菌群在HR-HPV感染中的作用。方法 分析2015年1月至2016年12月于中国医科大学附属盛京医院妇科门诊就诊的1 660例宫颈细胞学（TCT）阴性育龄女性HR-HPV感染、细菌性阴道病（BV）、滴虫阴道炎（TV）及外阴阴道假丝酵母菌病（VVC）的相关临床资料，根据结果分为HR-HPV阳性病例组228例，HR-HPV阴性对照组1 432例。组间率的比较采用χ²检验；非条件logistic回归分析HR-HPV感染与BV、TV、VVC的相关性。结果 病例组单纯性BV感染率（23.7%，54/228）明显高于对照组（13.0%，185/1 432，χ²=20.451，P < 0.001）；BV与HR-HPV感染风险呈正相关（OR=2.18，95% CI：1.55~3.08）。TV、VVC与HR-HPV感染无相关性（P > 0.05）。BV合并HPV感染者以HR-HPV为主，占90.1%（64/71）。结论 BV增加HR-HPV感染风险，可能促进宫颈癌变的过程。

1 660例育龄女性高危型人乳头瘤病毒感染与阴道菌群异常的相关性

刘霞, 张乔, 马宁耶

中国医科大学附属盛京医院妇产科, 沈阳 110004

收稿日期:2021-03-15出版日期:2021-11-30发布日期:2021-11-04
通讯作者:刘霞E-mail:liux3020@aliyun.com
作者简介:刘霞(1971-),女,副教授,博士.



关键词: 子宫颈肿瘤, 乳头状瘤病毒科, 阴道微生物群
Abstract: Objective Persistent high-risk human papillomavirus infection is the cause of uterine cervical cancer (CC) and its precursor, i.e., high-grade cervical intraepithelial neoplasm (CIN). The aim of this study was to investigate the association of high-risk human papillomavirus (HR-HPV) infection with vaginal dysbiosis, and to explore the role of vaginal microbiota in the process of HR-HPV infection. Methods A total of 1 660 women with cervical cytology-negative (TCT), who visited the gynecologic clinic at Shengjing hospital of China Medical University from January 2015 to December 2016 were enrolled in this study. Clinical data related to HPV infection, bacterial vaginitis (BV), trichomonal vaginitis (TV) and vulvovaginal candidiasis (VVC) were retrieved. The case group included 228 HR-HPV positive patients, while the controls composed of 1 432 HR-HPV negative women. The rates of each group were compared using the chi-square test, and the associations of HR-HPV infection with BV, TV, and VVC were analyzed using unconditional logistic regression. Results The prevalence of simple BV in the case group (23.7%, 54/228) was obviously higher than that of the controls (13.0%, 185/1 432) (χ²=20.451, P < 0.001). Moreover, BV was positively related to the risk of HR-HPV infection (OR=2.18, 95% CI:1.55-3.08). TV or VVC was not associated with HR-HPV infection (P > 0.05).The majority of patients infected with HPV and BV were HR-HPV positive, accounting for 90.1% (64/71). Conclusion BV increases the risk of HR-HPV infection, which might contribute to the process of cervical carcinogenesis.
Key words: uterine cervical neoplasms, papillomavirdae, vaginal microbiota
PDF全文下载地址:

https://journal.cmu.edu.cn/CN/article/downloadArticleFile.do?attachType=PDF&id=2881