摘要： 目的 探讨Raf激酶抑制蛋白（RKIP）在非小细胞肺癌（NSCLC）中的表达及其与NSCLC放射敏感性的关系。方法 应用免疫组化方法检测106例放射治疗前NSCLC组织中RKIP蛋白的表达。应用logistic回归分析NSCLC放射敏感性相关因素。结果 RKIP表达与NSCLC临床分期及淋巴结转移相关（P<0.05）。临床分期及RKIP表达水平与NSCLC的放射敏感性具有相关性（P<0.05），临床分期早、RKIP表达水平高的患者放射敏感性高。RKIP表达是NSCLC放射敏感性的独立相关因素。结论 RKIP是评价NSCLC放射敏感性的关键指标。

Raf激酶抑制蛋白表达水平与非小细胞肺癌放射敏感性的关系

韩冲, 于洋洋, 党军, 姚雷, 李光

中国医科大学附属第一医院放射治疗科, 沈阳 110001

收稿日期:2020-11-24出版日期:2021-09-30发布日期:2021-09-18
通讯作者:李光E-mail:13804058616@163.com
作者简介:韩冲(1987-),女,医师,博士.
基金资助:辽宁省科技厅科学技术计划（2013225021-27）


关键词: 非小细胞肺癌, Raf激酶抑制蛋白, 放射敏感性
Abstract: Objective To investigate Raf kinase inhibitor protein (RKIP) expression in non-small cell lung cancer (NSCLC),and its relationship with NSCLC radiosensitivity. Methods Immunohistochemical staining was used to detect the RKIP protein expressions of tissue samples from 106 NSCLC patients prior to radiotherapy. The factors affecting the radiosensitivity of NSCLC were analyzed with multivariate logistic analysis. Results RKIP expression was correlated with NSCLC clinical staging and lymph node metastasis (P<0.05). Moreover,clinical staging and RKIP expression levels were correlated with NSCLC radiosensitivity (P<0.05). Early clinical stage patients with high RKIP expressions had high radiosensitivity,thus RKIP expression was determined as an independent associated factor for NSCLC radiosensitivity. Conclusion RKIP is a key biomarker for evaluating NSCLC radiosensitivity.
Key words: non-small cell lung cancer, Raf kinase inhibitor protein, radiosensitivity
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