摘要： 长期以来，普遍认为慢性病与细颗粒物2.5（PM2.5）等环境因素紧密相关。针对空气污染造成的健康危害，市民可以通过改变生活方式提升生活质量，如增加有氧运动和摄入适量的抗氧化物质。虽有研究指出羟基酪醇可抵抗PM2.5暴露所致肥胖及胰岛素抵抗作用，但其机制尚不明确。因此，本文从PM2.5暴露引起肥胖及胰岛素抵抗的可能机制出发，探究羟基酪醇对PM2.5暴露引起的肥胖及胰岛素抵抗的保护作用。

羟基酪醇对细颗粒物2.5暴露所致肥胖及胰岛素抵抗的保护作用

马亚楠^1,2, 王宁宁³, 孙明丽⁴, 李亚虹¹, 胡嘉晋², 刘洋², 闻德亮²

1. 中国医科大学公共卫生学院卫生统计教研室, 沈阳 110122;
2. 中国医科大学健康科学研究院, 沈阳 110122;
3. 大连医科大学公共卫生学院营养与食品卫生学教研室, 辽宁 大连 116044;
4. 中国医科大学第二临床学院2017级, 沈阳 110122

收稿日期:2020-12-08出版日期:2021-03-30发布日期:2021-03-20
通讯作者:闻德亮E-mail:dlwen@cmu.edu.cn
作者简介:马亚楠(1982-),男,副教授,博士.
基金资助:辽宁省“兴辽英才计划”（XLYC1808036）；辽宁省自然基金（20180530054）


关键词: 肥胖, 胰岛素抵抗, 羟基酪醇, 细颗粒物2.5
Abstract: It has long been established that chronic diseases,such as obesity and insulin resistance,are closely related to environmental factors,such as particulate matter 2.5 (PM2.5). For protecting themselves from health hazards caused by air pollution and improving their quality of life,citizens can make lifestyle changes,such as increasing aerobic exercise and appropriate antioxidant intake in daily life. Although studies indicate that hydroxytyrosol can protect against the effects of PM2.5 exposure,which causes obesity and insulin resistance,the specific action mechanism remains unclear. Therefore,in this article,we discuss the possible mechanism of obesity and insulin resistance caused by PM2.5 exposure and explore the protective effect of hydroxytyrosol against PM2.5 exposure-induced obesity and insulin resistance.
Key words: obesity, insulin resistance, hydroxytyrosol, particulate matter 2.5
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