2010年及2019年沈阳地区育龄期孕妇孕晚期血脂水平变化分析
宋贵玉1, 王冰冰1,2, 王丹1, 那全1, 黄岭1, 乔宠11. 中国医科大学附属盛京医院妇产科, 沈阳 110004;
2. 北部战区总医院妇产科, 沈阳 110016
收稿日期:
2020-04-03出版日期:
2020-11-30发布日期:
2020-10-31通讯作者:
乔宠E-mail:qiaochong2002@163.com作者简介:
宋贵玉(1987-),女,主治医师,博士.基金资助:
国家重点研发计划(2016YFC1000404);国家自然科学基金(81771610,81370735);国家自然科学基金青年基金(81300492,81601289);辽宁省****项目(2017);盛京自由研究者基金(201706)关键词: 胆固醇, 甘油三酯, 孕晚期
Abstract: Objective To investigate the changes in serum lipid levels in pregnant women in 2010 and 2019 in Shenyang. Methods A total of 5 070 pregnant women were recruited at Shengjing Hospital of China Medical University in 2010 and 2019. The women were divided into the 2010 group and the 2019 group according to the year of delivery. The clinical data of the pregnant women were collected, and the levels of triglyceride(TG),total cholesterol(TC),high-density lipoprotein(HDL),low-density lipoprotein(LDL),apolipoprotein A1(ApoA1),and apolipoprotein B(ApoB)in the fasting serum of the two groups were detected at 1 week before delivery. Results The levels of TG,TC,HDL,LDL,ApoA1,and ApoB in the 2019 group were significantly higher than those in the 2010 group(3.57±1.52 vs. 3.22±1.55 mmol/L,P<0.01;6.37±1.18 vs. 6.01±1.22 mmol/L,P<0.01;1.89±0.43 vs. 1.83±0.43 mmol/L,P<0.01;3.52±1.02 vs. 3.26±0.98 mmol/L,P<0.01;2.29±0.39 vs. 1.97±0.38 mmol/L,P<0.01;and 1.26±0.30 vs. 1.23±0.33 mmol/L,P<0.05, respectively). The levels of TG,TC,HDL,and LDL in pregnant women of different ages were also significantly higher in the 2019 group than in the 2010 group,and the levels of TG and TC gradually increased with the increase in maternal age. Conclusion The serum lipid levels of pregnant women in late pregnancy significantly increased in the recent 10 years in Shenyang,and the changes of TG and TC levels increased with increasing maternal age.
Key words: triglyceride, cholesterol, childbearing period
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