结直肠癌患者术前血浆纤维蛋白原、癌胚抗原、糖类抗原19-9水平与临床病理特征的关系
辛衡, 周建平, 高威, 董明中国医科大学附属第一医院胃肠外科/疝与腹壁外科, 沈阳 110001
收稿日期:2020-08-27出版日期:2020-11-30发布日期:2020-10-31通讯作者:周建平E-mail:zjphama@163.com作者简介:辛衡(1994-),男,医师,硕士.基金资助:辽宁省重点研发计划“医学科技成果转化专项”项目（辽科发2019-24）关键词: 纤维蛋白原, 癌胚抗原, 糖类抗原19-9, 结直肠癌, TNM肿瘤分期
Abstract: Objective To investigate the relationship between preoperative plasma levels of fibrinogen(FIB),carcinoembryonic antigen(CEA),and carbohydrate antigen 19-9(CA19-9)with the clinicopathological features of colorectal cancer patients. Methods We retrospectively selected 176 colorectal cancer patients who underwent surgery at our department from January 2016 to December 2018(colorectal cancer group)and 100 healthy people who underwent physical examination at our hospital during the same period as a control group. The clinical data of the subjects including plasma levels of FIB,CEA,and CA19-9 were recorded and compared between the two groups. The relationship between the preoperative plasma levels of FIB,CEA,and CA19-9 with the clinicopathological features of colorectal cancer was analyzed. Results The preoperative plasma levels of FIB,CEA,and CA19-9 in the colorectal cancer group were significantly higher than those in the control group(P<0.05). In the colorectal cancer group,the preoperative plasma levels of FIB,CEA, and CA19-9 increased with tumor invasion depth,lymphatic metastasis,and TNM staging(P<0.05). Conclusion The preoperative plasma levels of FIB,CEA,and CA19-9 in colorectal cancer patients are closely related to the development stage of the tumor and can be used as a basis to predict the TNM staging of the tumor.
Key words: fibrinogen, carcinoembryonic antigen, carbohydrate antigen 19-9, colorectal cancer, TNM staging
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