摘要： 目的 观察不同降糖方案对初诊且未接受过降糖药物治疗的2型糖尿病患者辛酰化ghrelin（AG）和非辛酰化ghrelin（UAG）水平的影响，以及与血糖、胰岛β细胞功能等的关系。方法 将16例初诊2型糖尿病患者随机分为3组，分别给予艾塞那肽（n=5）、胰岛素（n=6）或吡格列酮（n=5）降糖治疗48周，降糖治疗前后采血测定空腹、餐后30 min、餐后2 h的AG、UAG、胰岛素、血糖水平。结果 降糖治疗后，空腹和餐后2 h的AG/UAG比值较治疗前显著升高（均P<0.05）。空腹的AG/UAG比值与糖化血红蛋白呈负相关（r=-0.495，P=0.004），餐后2 h的AG/UAG比值与餐后2 h血糖呈负相关（r=-0.393，P=0.026）。结论 AG/UAG比值升高与血糖良好控制相关，其变化在不同降糖方案间无显著差异。

初诊2型糖尿病患者降糖治疗前后ghrelin水平的变化

黄明诗¹, 王颜蕾², 李玉姝¹

1. 中国医科大学附属第一医院内分泌科, 内分泌研究所, 辽宁省内分泌重点实验室, 沈阳 110001;
2. 中国航天科工集团七三一医院内分泌科, 北京 100071

收稿日期:2019-02-27出版日期:2020-09-30发布日期:2020-09-15
通讯作者:李玉姝E-mail:liyushu@hotmail.com
作者简介:黄明诗(1991-),女,硕士研究生.
基金资助:国家自然科学基金（81770784）


关键词: 初诊2型糖尿病, 辛酰化ghrelin, 非辛酰化ghrelin
Abstract: Objective To investigate the effects of different hypoglycemic therapies on the levels of acylated ghrelin (AG) and unacylated ghrelin (UAG) in newly-diagnosed type 2 diabetes mellitus patients,and analyze the correlation between the levels of AG and UAG and blood glucose or β cell function. Methods Sixteen patients were randomly divided into 3 groups and treated with exenatide (n=5),insulin (n=6),or pioglitazone (n=5) for 48 weeks. The levels of AG,UAG,insulin,and blood glucose were measured at fasting and at 30 minutes and 2 hours after a meal. Results The ratio of AG to UAG (AG/UAG) at fasting and 2 hours after a meal was significantly increased after hypoglycemic therapy (P<0.05). AG/UAG at fasting was negatively correlated with glycosylated hemoglobin A1c (r=-0.495,P=0.004). There was a negative correlation between the AG/UAG ratio and blood glucose levels at 2 hours after a meal (r=-0.393,P=0.026). Conclusion The increase in the AG/UAG ratio was associated with good glycemic control,but the change was not significantly different between the different hypoglycemic therapies.
Key words: newly-diagnosed type 2 diabetes mellitus, acylated ghrelin, unacylated ghrelin
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