摘要： 目的 研究代谢综合征（MS）与高龄女性卵巢癌的关系，以及MS相关指标水平对卵巢癌的诊断和预防是否具有辅助作用。方法 收集121例卵巢肿物患者的临床资料，其中61例卵巢癌患者为恶性组，60例卵巢良性肿瘤患者为良性组，比较2组患者相关指标水平（空腹血糖、收缩压、舒张压、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯、D-二聚体）、异常代谢（包括超重或肥胖、代谢紊乱、高血压、高血糖）发生率、MS发病率。同时另外选取117例卵巢癌患者，其中56例患者年龄≤ 60岁，61例患者年龄>60岁，比较2组患者相关指标水平、异常代谢发生率、MS发病率。结果 恶性组MS发病率较高，与卵巢癌发生率呈正相关。患有MS的高龄女性患卵巢癌的风险是正常高龄女性的4.565倍（OR=4.565，95% CI：1.417~14.707，P<0.05）；血糖和D-二聚体水平升高与卵巢癌发病显著相关，且与血糖相比，D-二聚体水平升高对卵巢癌的诊断更有意义。年龄≤ 60岁与年龄>60岁的卵巢癌患者比较，MS相关指标的差异均无统计学意义。结论 MS可提高高龄女性卵巢癌发生率，血糖和D-二聚体水平升高是卵巢癌发病的独立危险因素。D-二聚体结合其他检查有助于卵巢癌的诊断和治疗，可作为卵巢癌辅助诊断的指标。卵巢癌患者中，MS相关指标与年龄无明显相关性。

代谢综合征与高龄女性卵巢癌的相关性

高晨曦¹, 卢辉², 邓雷¹, 田东立¹, 张颐¹

1. 中国医科大学附属第一医院妇科, 沈阳 110001;
2. 济宁市任城区妇幼保健院产科, 山东 济宁 227200

收稿日期:2019-09-10出版日期:2020-09-30发布日期:2020-09-15
通讯作者:张颐E-mail:zhangyi@cmu1h.com
作者简介:高晨曦(1995-),女,硕士研究生.
基金资助:辽宁省自然科学基金（2014021021）；中国医科大学2019年度临床医学培育学科支持计划


关键词: 代谢综合征, 卵巢癌, 卵巢良性肿瘤, 高龄妇女, 病例对照研究
Abstract: Objective To investigate the relationship between metabolic syndrome (MS) and ovarian cancer in elderly women and verify whether the level of MS-related indexes can assist in the diagnosis and prevention of ovarian cancer. Methods A total of 121 patients with ovarian neoplasm were selected,including 61 patients with ovarian cancer (malignant group) and 60 patients with ovarian benign tumor (benign group). In addition,117 patients with ovarian cancer were selected and divided into ≤ 60 years group (n=56) and >60 years group (n=61). The level of MS-related indexes (fasting blood glucose,systolic blood pressure,diastolic blood pressure,high-density lipoprotein,low-density lipoprotein,total cholesterol,triglyceride,and D-dimer) and the incidences of abnormal metabolism (overweight or obesity,metabolic disorder,hypertension,and hyperglycemia) and MS were compared between these groups. Results The incidence of MS in the malignant group was high,and it was positively correlated with the incidence of ovarian cancer. Moreover,an increase in the fasting blood glucose and D-dimer levels were significantly correlated with the incidence of ovarian cancer. No significant difference in the MS-related indexes was found between the ≤ 60 years and >60 years groups. Conclusion MS can increase the incidence of ovarian cancer in elderly women. Moreover,increases in the blood glucose and D-dimer levels are independent risk factors for ovarian cancer. D-dimer combined with other tests will be helpful for the diagnosis and treatment of ovarian cancer.
Key words: metabolic syndrome, ovarian cancer, ovarian benign tumor, elderly women, case-control study
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