摘要： 组蛋白甲基转移酶SUV4-20H为哺乳动物组蛋白H4第20位赖氨酸（H4K20）的特异性甲基转移酶，在人体组织中广泛表达。SUV4-20H蛋白本身及其介导的H4K20甲基化修饰，均可导致染色质致密化及基因抑制，从而影响调控基因的转录与表达。近年来，随着国内外****的深入研究，SUV4-20H基因及其编码蛋白在组织器官发育、肿瘤疾病等生理及病理生理过程中的作用机制逐渐被揭示。本文对SUV4-20H基因及其编码蛋白的生物学特征及其在疾病发生发展过程中的作用进行综述，以期进一步理解甲基化转移酶对基因表达调控的影响，为相关疾病的预防和诊治奠定理论基础。

组蛋白甲基转移酶SUV4-20H的研究进展

赵丹洋, 姜红, 姜红堃

中国医科大学附属第一医院儿科, 沈阳 110001

收稿日期:2019-11-06出版日期:2020-08-30发布日期:2020-08-04
通讯作者:姜红堃E-mail:jianghongkun007@163.com
作者简介:赵丹洋(1995-),女,硕士研究生.
基金资助:国家自然科学基金（81300130）；辽宁省教育厅科技基金（LFWK201701）


关键词: 组蛋白甲基转移酶, 组蛋白4赖氨酸20, 组蛋白甲基化, 组蛋白甲基转移酶, 表观遗传学
Abstract: The histone methyltransferase SUV4-20H is a specific methyltransferase of lysine at the 20th position of the mammalian histone H4 (H4K20),which is widely expressed in human tissues. SUV4-20H protein itself and the protein-mediated methylation of H4K20 can lead to chromatin densification and gene inhibition,which regulate gene transcription and expression. In recent years,with in-depth studies on SUV4-20H by domestic and foreign scholars,the mechanism of SUV4-20H gene and SUV4-20H protein action in the development of various tissues and organs,tumors,and other physiological and pathophysiological processes has been gradually revealed. This paper will outline the research progress on the SUV4-20H gene,SUV4-20H protein characteristics,biological functions,and their impact on disease progression,so as to understand the influence of methyltransferase on gene expression and regulation and lay a theoretical foundation for studies on the prevention,diagnosis,and treatment of related diseases.
Key words: suppressor of variegation 4-20 homolog, histone 4 lysine 20, histone methylation, histone methyltransferases, epigenetics
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