摘要： 目的 比较不同设计的疏水性丙烯酸酯人工晶状体襻与光学区的黏性。方法 选取4种人工晶状体(HOYA iSert^®251,Lucia 601P,Tecnis ZCB00,IQ SN60WF),在添加及不添加粘弹剂状态下将襻折叠于光学区中央,并施加0.02~0.7 N的作用力,观察并记录襻与光学区的分离时间,即黏附分离时间。对各组的黏附分离时间和力进行线性回归分析,并对黏性进行比较。结果 无粘弹剂时,Lucia 601P、Tecnis ZCB00、IQ SN60WF的黏附分离时间均>200 s,而相同外力条件下,HOYA iSert^®251的黏附分离时间明显低于其他3组;添加粘弹剂时,4种IOL均可产生襻黏附现象,且黏附分离时间随力的增大而延长。线性回归结果显示,黏附分离时间均与力存在线性关系(P<0.01),黏性大小关系(斜率)为HOYA iSert^®251 < Tecnis ZCB00 < IQ SN60WF < Lucia 601P。结论 疏水性丙烯酸酯IOL会出现襻与光学区的黏附分离现象,添加粘弹剂时黏附时间缩短,HOYA iSert^®251的聚甲基丙烯酸甲酯(PMMA)支撑部前端设计减少了粘襻现象的发生。

不同设计疏水性丙烯酸酯人工晶状体襻黏性对比研究

胡艺平¹, 王静², 李史序³, 刘彧琦¹, 李博文¹, 张劲松²

1. 中国医科大学附属第四医院眼科, 中国医科大学眼科医院, 辽宁省晶状体学重点实验室, 沈阳 110005;
2. 沈阳爱尔卓越眼科医院眼科, 沈阳 110001;
3. 山东省眼科医院眼科, 济南 250000

收稿日期:2019-11-14出版日期:2020-06-30发布日期:2020-06-15
通讯作者:张劲松E-mail:cmu4h-zjs@126.com
作者简介:胡艺平(1995-),女,硕士研究生.
基金资助:辽宁省卫生健康委员会辽宁省基层卫生适宜技术推广项目（LHATP-201805）


关键词: 白内障, 人工晶状体, 疏水性丙烯酸酯, 粘襻现象
Abstract: Objective To compare the adhesion between the optic and haptic of a hydrophobic acrylic intraocular lens (IOL) with different designs. Methods Four IOLs are selected and their haptic folded on the center of the optic at standard room temperature with or without visco. Apply a force in the range of 0.02 N-0.7 N at intervals of 0.02 N. Observe and record the adhesion-separation time. Compare the adhesion-separation time,analyzed by linear regression. Results At room temperature without visco,the adhesion-separation time of Lucia 601P,Tecnis ZCB00,and IQ SN60WF between the haptic and optic is more than 200 s. While under the same external force condition,the adhesion-separation time of the HOYA iSert^®251 IOL was significantly lower than the other three groups. At room temperature with visco,four kinds of IOLs' haptics and optics could produce haptic adhesion under external forces with the adhesion-separation time increasing with the increase of the force. There is a linear relationship between adhesion-separation time and force (P<0.01). The relationship between each adhesion (slope) is as follows:HOYA iSert^®251 < Tecnis ZCB00 < IQ SN60WF < Lucia 601P. Conclusion The adhesion and separation between the haptic and optic appear in the hydrophobic acrylate intraocular lens and the adhesion time reduces when visco is added. The design of the blue poly (methyl methacrylate) (PMMA) chemically bonded haptic tips reduces the adhesion between the IOL's haptics and optics.
Key words: cataract, intraocular lens, hydrophobic acrylic, haptic adhesion
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