摘要： 目的 探讨羟考酮注射液复合右美托咪定用于剖宫产术后镇痛的可行性及效果。方法 选取择期剖宫产产妇132例。按随机数表法分成实验组及对照组,每组66例,术后实验组行羟考酮、右美托咪定静脉输注,对照组行舒芬太尼等效剂量镇痛,对比2组预后。结果 术后24 h、48 h 2组疼痛阈值较术前升高,实验组更高(P<0.05)。实验组术后6~48 h切口痛视觉模拟评分(VAS)和宫缩痛评分较对照组低,Bruggrmann舒适量表(BCS)评分较对照组高(P<0.05)。2组术后24 h和48 h血清泌乳素(PRL)较术前升高,实验组更高(P<0.05)。实验组自我感觉满意度较对照组高,初乳时间和术后排气时间较对照组早,并发症的发生率较对照组低(P<0.05)。实验组产妇产后72 h泌乳量明显优于对照组(P<0.05)。结论 羟考酮注射液复合右美托咪定用于剖宫产术后镇痛的效果较好,安全性和可行性较高。

羟考酮注射液复合右美托咪定用于剖宫产术后镇痛的可行性及效果观察

李晶¹, 李铁成², 陈晓宇³

1. 锦州医科大学北部战区总医院研究生培养基地, 沈阳 110003;
2. 锦州医科大学附属第三医院麻醉科, 辽宁 锦州 121000;
3. 北部战区总医院麻醉科, 沈阳 110062

收稿日期:2019-12-24出版日期:2020-06-30发布日期:2020-06-15
通讯作者:李铁成E-mail:litiecheng777@163.com
作者简介:李晶(1985-),男,主治医师,硕士.



关键词: 羟考酮注射液, 右美托咪定, 剖宫产, 术后镇痛, 可行性, 效果
Abstract: Objective To study the analgesic effects and potential use of hydroxycodone injection combined with dexmetomide for postoperative analgesia after cesarean section. Methods The study included 132 participants who underwent cesarean section. Participants were randomized to the experimental group or the control number by using a random number table. After the operation,the experimental group received hydroxycodone and dexmetomide analgesia,and the control group received sufentanil for an equivalent dose of analgesia. Patient prognosis was compared between the two groups. Results At 24 h and 48 h after the operation,the pain threshold of both groups was higher than before the operation,and that of the experimental group was higher than the control group (P<0.05). From 6-48 h after the operation,the incision pain VAS score and the uterine contraction pain score of the experimental group were lower than those in the control group,and BCS score was higher than in the control group (P<0.05). In both groups,the serum PRL at 24 h and 48 h after operation was higher than before operation,although the levels in the experimental group were higher than in the control group (P<0.05). In the experimental group,self-sensory satisfaction was higher than in the control group,colostrum time and postoperative exhaustion time were shorter than in the control group,and the incidence of complications was lower than in control group (P<0.05). At 72 h after delivery,lactation in the experimental group was better than in the control group (P<0.05). Conclusion Hydroxycodone injection combined with dexmetomide was effective,safe,and feasible for postoperative analgesia after cesarean section.
Key words: hydroxycodone injection, dexmetomide, cesarean section, postoperative analgesia, feasibility, effect
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