摘要： 目的 研究阿尔茨海默病（AD）患者血清胆红素、血尿酸、血清白蛋白的临床特点及其与认知功能的相关性。方法 选择AD患者69例，健康对照组67例，采集简明精神状态量表（MMSE）评分、血清总胆红素、直接胆红素、间接胆红素、血尿酸和血清白蛋白，比较2组间各指标有无统计学差异，并将MMSE评分与血清胆红素、血尿酸和血清白蛋白进行多元回归分析。结果 2组的血清胆红素、血清白蛋白水平存在统计学差异；2组的血尿酸水平差异无统计学意义；AD组MMSE评分与年龄呈负相关，与血清总胆红素、直接胆红素、间接胆红素及血清白蛋白水平呈正相关；在控制各项因素后，MMSE评分与年龄、高血压病史、血尿酸及血清白蛋白水平显著相关。结论 血清总胆红素、直接和间接胆红素可能仅为AD的危险因素，而非独立危险因素，而血清白蛋白水平可能为AD的一个独立危险因素。血尿酸对于氧化应激具有双向作用，相对高水平的血尿酸可能促进AD的发生和发展。

血清胆红素、血尿酸和血清白蛋白与阿尔茨海默病的相关性研究

刘立娇, 孙蜀宁

辽宁省金秋医院神经内科二病房, 沈阳 110016

收稿日期:2019-01-03出版日期:2020-04-30发布日期:2020-04-18
通讯作者:孙蜀宁E-mail:ssnlxx@126.com
作者简介:刘立娇(1986-),女,主治医师,硕士.
基金资助:辽宁省省直医院改革重点临床科室诊疗能力建设项目（LNCCC-D39-2015）


关键词: 阿尔茨海默病, 血清胆红素, 血尿酸, 血清白蛋白
Abstract: Objective To study the clinical characteristics of serum bilirubin,uric acid,and albumin levels in patients with Alzheimer disease (AD) and their correlation with cognitive function. Methods We retrospectively evaluated 69 patients with AD and 67 healthy controls. We collected data on Mini-Mental State Examination (MMSE) scores and serum total bilirubin,direct bilirubin,indirect bilirubin,uric acid,and albumin levels from the patients in the two groups. Subsequently,we compared the biochemical indicators to determine whether statistically significant differences exist between the two groups,and multiple regression analysis was performed among the MMSE scores and serum levels of bilirubin,uric acid,and albumin. Results Significant differences in serum bilirubin and albumin levels,but not serum uric acid level,were found between the two groups. The MMSE scores in the AD group negatively correlated with age and the serum total bilirubin level. A positive correlation was observed between direct bilirubin,indirect bilirubin,and serum albumin levels. After controlling for various factors,the MMSE scores significantly correlated with age,history of hypertension,and serum uric acid and albumin levels. Conclusion Serum total,direct,and indirect bilirubin levels may be the only risk factors of AD,but they are not independent risk factors. Serum albumin level may be an independent risk factor of AD. Serum uric acid level has a two-way effect on oxidative stress,and this study supports the hypothesis that relatively high levels of serum uric acid level may contribute to the development and progression of AD.
Key words: Alzheimer disease, serum bilirubin, blood uric acid, serum albumin
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