摘要： 血管生成素样因子（ANGPTLs）是近年来发现的一类与血管生成素（ANG）在组成上具有同源性，并具有调节血管生成作用的分泌性糖蛋白家族。目前已发现ANGPTLs家族有8个成员（ANGPTL1~8），ANGPTL2、3、4主要通过调整糖脂代谢、影响血管生成等影响动脉硬化产生，本文就ANGPTLs蛋白家族各个成员特点、功能、致病机制及其与动脉硬化性疾病相关性的研究进展进行综述。

血管生成素样因子与动脉硬化性疾病的相关性研究进展

冷昶木, 盖晴, 丛树艳

中国医科大学附属盛京医院神经内科, 沈阳 110004

收稿日期:2019-04-11出版日期:2020-04-30发布日期:2020-04-18
通讯作者:丛树艳E-mail:congshuyan@hotmail.com
作者简介:冷昶木(1992-),女,医师,硕士.
基金资助:国家自然科学基金（81371271）


关键词: 血管生成素样因子, 糖脂代谢, 血管损伤, 动脉硬化
Abstract: Angiopoietin-like proteins (ANGPTLs),a family of secretory glycoproteins,were found to be constitutionally homologous with angiogenin,and play a role in the regulation of angiogenesis. There are eight members of the ANGPTLs family,which are known as ANGPTL1-8. ANGPTL2,ANGPTL3,and ANGPTL4 affect arteriosclerosis primarily by adjusting glucose and lipid metabolism,and by regulating angiogenesis. This study summarizes the characteristics,functions,and pathogenesis of each member of the ANGPTLs protein family. Additionally,advances in their relationship with arteriosclerotic disease were also reviewed.
Key words: angiopoietin-like proteins, glucolipid metabolism, vascular injury, arteriosclerosis
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