摘要： 目的 研究磷脂酰肌醇-3-激酶（PI3K）和血管内皮生长因子-C（VEGF-C）在口腔颌面部淋巴管畸形中的表达。方法 应用免疫组化SP法检测35例淋巴管畸形组织和10例正常淋巴组织中PI3K和VEGF-C的表达情况。结果 淋巴管畸形组织中，PI3K的阳性表达率为80.00%（28/35），VEGF-C的阳性表达率为88.57%（31/35）；正常淋巴组织中，PI3K和VEGF-C的阳性表达率均为0%（0/10）。淋巴管畸形组织中PI3K、VEGF-C的阳性表达率明显高于正常淋巴组织（均P<0.05）。淋巴管畸形组织，PI3K与VEGF-C的阳性表达呈正相关。结论 PI3K、VEGF-C与淋巴管畸形内皮细胞增殖有关。

PI3K和VEGF-C在口腔颌面部淋巴管畸形中的表达

宋柏璇^1,2, 于丽³, 赵振坤⁴, 赵志国¹, 王秋旭¹

1. 中国医科大学附属盛京医院口腔颌面外科, 沈阳 110004;
2. 辽阳市中心医院口腔科, 辽宁 辽阳 111009;
3. 杭州口腔医院特诊科, 杭州 310012;
4. 中国医科大学附属盛京医院病理科, 沈阳 110004

收稿日期:2018-12-01出版日期:2020-02-29发布日期:2019-12-26
通讯作者:王秋旭E-mail:wangqx@sj-hospital.org
作者简介:宋柏璇(1992-),女,医师,硕士.



关键词: 口腔颌面部淋巴管畸形, 磷脂酰肌醇-3-激酶, 血管内皮生长因子-C
Abstract: Objective To investigate the expression of phosphoinositide 3-kinase(PI3K)and vascular endothelial growth factor-C (VEGF-C)in oral and maxillofacial lymphatic malformations. Methods The immunohistochemical SP method was used to detect the expression of PI3K and VEGF-C in 35 cases of lymphatic malformation and 10 cases of normal lymphoid tissue. Results In lymphatic malformation tissues,the positive expression rates of PI3K and VEGF-C were 80%(28/35)and 88.57%(31/35),respectively. In normal lymphoid tissues,the positive expression rates of both PI3K and VEGF-C were 0%(0/10). The positive expression rates of PI3K and VEGF-C in lymphatic malformation tissues were significantly higher than those in normal lymphoid tissues(P<0.05). There was a positive correlation between the positive expression of PI3K and VEGF-C in lymphatic malformation tissues. Conclusion PI3K and VEGF-C are involved in endothelial cell proliferation in lymphatic malformations.
Key words: oral and maxillofacial lymphatic malformation, phosphoinositide 3-kinase, vascular endothelial growth factor-C
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