摘要： 目的 探讨应用微生态制剂双歧杆菌四联活菌片联合恩替卡韦治疗乙型肝炎肝硬化的临床疗效。方法 选取2017年1月至2018年12月我科收治的80例乙型肝炎肝硬化患者，将入组患者随机分为实验组和对照组，对照组患者接受恩替卡韦单药治疗，实验组患者在恩替卡韦治疗的基础上加用微生态制剂治疗。治疗6个月后，通过监测研究对象厌食、乏力、腹胀症状的发生率，监测肝功能和肝纤维化指标的变化，评定2组的疗效。结果 治疗后2组乏力、厌食、腹胀症状的发生率均较治疗前明显降低，实验组比对照组降低更为显著，差异有统计学意义（P<0.05）。治疗后2组谷草转氨酶、谷丙转氨酶、总胆红素的水平均较治疗前明显降低，实验组比对照组降低更为显著，差异有统计学意义（P<0.05）。治疗后2组透明质酸、Ⅲ型前胶原、层黏蛋白水平的水平均较治疗前明显降低，实验组比对照组降低更为显著，差异有统计学意义（P<0.05）。结论 恩替卡韦联合微生态制剂治疗与恩替卡韦单药治疗，均可改善乙型肝炎肝硬化患者预后，前者疗效更佳。

微生态制剂联合恩替卡韦治疗乙型肝炎肝硬化的临床疗效

那妍, 娄宪芝

沈阳医学院附属中心医院感染科, 沈阳 110024

收稿日期:2019-10-24出版日期:2020-02-29发布日期:2019-12-26
通讯作者:那妍E-mail:781107@qq.com
作者简介:那妍(1978-),女,副主任医师,硕士.
基金资助:辽宁省自然科学基金（20170540882）


关键词: 乙型肝炎, 肝硬化, 恩替卡韦, 微生态制剂, 双歧杆菌四联活菌片
Abstract: Objective To evaluate the efficacy of entecavir combined with probiotics in patients with hepatitis B virus-related cirrhosis. Methods Eighty patients with hepatitis B virus-related cirrhosis admitted to our hospital between January 2017 and December 2018 were included in this study. The patients were randomly divided into the control group(entecavir treated)and the study group(entecavir plus probiotics treated). After 6 months,the treatment efficacy in these two groups was assessed,based on the incidences of fatigue,abdominal distension,and anorexia,and changes in the indicators of liver function and fibrosis. Results The incidences of fatigue,abdominal distension,and anorexia decreased after treatment in both groups and were lower in the study group than in the control group (P<0.05). Similarly,the levels of glutamic-pyruvic transaminase,glutamic-oxaloacetic transaminase,total bilirubin,hyaluronic acid,procollagenⅢ, and laminin decreased after treatment in both groups and were lower in the study group than in the control group(P<0.05). Conclusion Entecavir combined with probiotics has a better therapeutic effect compared to entecavir monotherapy in patients with hepatitis B virus-related cirrhosis.
Key words: hepatitis B, cirrhosis, entecavir, probiotics, Bifidobacterium tetragenous viable bacteria
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