导师基本信息
姓　　名
袁媛
导师类别
博导

性别
女
招生年度
2020

出生年月
195610
专业职称
主任医师

院系
第一临床学院
政治面貌
中国共产党党员

科室
肿瘤研究所三室（肿瘤病因与筛查研究室）
手机
*********

工作单位
第一临床学院
学术职称
教授

最后学位
医学博士学位
办公室电话
*********

最后学历
博士研究生
电子信箱
yuanyuan@cmu.edu.cn

个人简介　　　
袁媛，国家二级教授，博士研究生导师，中国医科大学第一临床学院肿瘤病因与筛查研究室主任，中国医科大学胃癌预防监控中心主任，辽宁省高校肿瘤病因与预防重点实验室主任。辽宁省“袁媛劳模创新工作室”领衔人。国家卫计委癌症早诊早治项目专家委员会胃癌专家组副组长。国家有突出贡献的中青年科学专家，国务院政府特殊津贴获得者，全国“五一”劳动奖章获得者，全国先进工作者。袁媛教授长期致力于消化道肿瘤病因及发病机制、人群筛查与早诊早治研究，擅长消化道疾病临床病理诊断。主持完成30余项国家科技攻关、科技支撑、 “973”、自然科学基金及省部级科研项目，获多项部省级奖励，发表学术论文200余篇，主编参编胃癌专著6部。指导博硕士研究生80余名。
研究方向简介　　
重点从事消化道肿瘤病因、发病机制及早诊早治研究。主要研究方向包括胃癌高发现场高危人群筛查及早诊早治研究；消化道肿瘤高风险人群识别及其发病机制研究；消化道肿瘤预警预后标志物研究以及幽门螺杆菌致病性及耐药性研究等。
社会兼职　　　
国家卫计委癌症早诊早治项目专家委员会胃癌专家组副组长中国抗癌协会肿瘤病因学专业委员会委员中关村（泛亚）消化内镜技术创新战略联盟常务理事）国家消化系肿瘤研究协同创新中心理事辽宁省抗癌协会常务理事
所获荣誉　　　
国家级有突出贡献的中青年科技专家 国务院政府特殊津贴获得者 全国先进工作者 全国五一劳动奖章获得者 辽宁省优秀共产党员 辽宁省优秀专家

在学研究生
硕士学术学位人数 博士学术学位人数
硕士专业学位人数 博士专业学位人数
同等学力硕士学术学位人数 同等学力博士学术学位人数
同等学力硕士专业学位人数 同等学力博士专业学位人数
研究生就业　　　(300字内)
1995年至今二十年来，袁媛教授指导培养博士研究生44名，硕士研究生43名,博士后2名。已毕业博、硕士77名，100%就业。目前，袁媛教授培养的研究生绝大部分工作在医疗战线，主要从事临床肿瘤科、病理科、消化科等专业工作以及基础研究与预防医学研究工作，部分毕业生出国深造。

教育经历
时间（起始年-截止年） 毕业院校 专业名称 所获学位
197802-198212 中国医科大学 临床医学 医学学士学位
198609-198806 中国医科大学 肿瘤学 医学硕士学位
199109-199406 中国医科大学 病理学 医学博士学位
工作经历
时间（起始年-截止年） 工作单位 承担职务 从事工作
199707- 中国医科大学第一临床学院 教授；研究员 肿瘤学（肿瘤病因及肿瘤病理学）
199807-今 中国医科大学第一临床学院 室主任；教授；研究员 肿瘤学（肿瘤病因及肿瘤病理学）
200707-今 中国医科大学第一临床学院 副所长；室主任；二级教授 肿瘤学（肿瘤病因及肿瘤病理学）
承担课题(近5年)
时间（起始年月-截止年月） 批准部门 课题名称 课题经费(万)
201801-202112 国家自然科学基金 circ_1483通过募集let_7c解除胃癌组织中胃粘膜分化抗原PGC表达沉默的分子机制研究 50
201801-202112 "十三五“国家重点研发计划”精准医学研究“子课题 东北区域自然人群队列研究 236.25
201607-201806 中央补助地方重大公共卫生事业专项 庄河胃癌早诊早治项目 36.72
201504-201712 国家科技部 临床医学研究(消化疾病)协同网络建设示范应用研究 24
学术论文(近5年)
文章题目 杂志名称 发表年 卷期页 收录情况 影响因子
Genetic Polymorphisms of DNA Repair Pathways in Sporadic Colorectal Carcinogenesis J Cancer 2019 10(6):0 SCI 3.182
Four novel polymorphisms in long non-coding RNA HOTTIP are associated with the risk and prognosis of colorectal cancer Biosci Rep 2019 39(5):0 SCI 2.535
The interaction effects between TLR4 and MMP9 gene polymorphisms contribute to aortic aneurysm risk in a Chinese Han population BMC Cardiovasc Disord 2019 19(1):0 SCI 1.947
Comprehensive Analysis of Aberrantly Expressed ceRNA network in gastric cancer with and without H.pylori infection J Cancer 2019 10(4):0 SCI 3.182
Competitive Endogenous RNA (ceRNA) Regulation Network of lncRNA-miRNA-mRNA in Colorectal Carcinogenesis Dig Dis Sci 2019 2():0 SCI 2.937
Epigenetic Alternations of MicroRNAs and DNA Methylation Contribute to Liver Metastasis of Colorectal Cancer Dig Dis Sci 2019 64(6):0 SCI 2.937
TLR4 and MMP2 polymorphisms and their associations with cardiovascular risk factors in susceptibility to aortic aneurysmal diseases Biosci Rep 2019 39(1):0 SCI 2.535
Five P53 SNPs Involved in Low Rectal Cancer Risk and Prognosis in a Chinese Population J Cancer 2019 10(7):0 SCI 3.182
Identification of differentially expressed genes between triple and non-triple-negative breast cancer using bioinformatics analysis Breast Cancer 2019 6():0 SCI 2.044
Mucosa-Associated Microbiota in Gastric Cancer Tissues Compared With Non-cancer Tissues Front Microbiol 2019 10():0 SCI 4.259
Clinical significance of serum markers reflecting gastric function and H. pylori infection in colorectal cancer J Cancer 2019 10(10):0 SCI 3.182
The antibiotic resistance of Helicobacter pylori to five antibiotics and influencing factors in an area of China with a high risk of gastric cancer BMC Microbiol 2019 19(1):0 SCI 3.287
The Differential Expression of Core Genes in Nucleotide Excision Repair Pathway Indicates Colorectal Carcinogenesis and Prognosis Biomed Res Int 2018 1(15):0 SCI 2.583
Resistance mechanisms of Helicobacter pylori and its dual target precise therapy Critical Reviews in Microbiology 2018 44(3):0 SCI 4.738
Serum Toll-like receptor 4: A novel and promising biomarker for identification of aortic aneurysmal diseases Clin Chim Acta 2018 483(1):0 SCI 2.926
DNA repair protein XPA is differentially expressed in colorectal cancer and predicts better prognosis Cancer Med 2018 7(6):0 SCI 3.202
Expression of Minichromosome Maintenance Proteins (MCM) and Cancer Prognosis: A meta-analysis J Cancer 2018 9(8):0 SCI 3.249
The association of lncRNA-HULC polymorphisms with hepatocellular cancer risk and prognosis Gene 2018 5():0 SCI 2.498
Alternative splicing events implicated in carcinogenesis and prognosis of colorectal cancer J Cancer 2018 9(10):0 SCI 3.249
MLH1 Promoter Methylation and Prediction/Prognosis of Gastric Cancer: A Systematic Review and Meta and Bioinformatic Analysis J Cancer 2018 9(11):0 SCI 3.249
Association of twelve polymorphisms in three onco-lncRNA genes with hepatocellular cancer risk and prognosis: A case-control study World J Gastroenterol. 2018 24(23):0 SCI 3.3
Pepsinogen C expression, regulation and its relationship with cancer Cancer Cell Int 2017 17(57):0 SCI 3.96
Long non-coding RNA polymorphisms in 6p21.1 are associated with atrophic gastritis risk and gastric cancer prognosis Oncotarget 2017 8(56):0 SCI 5.168
Three-dimensional combined biomarkers assay could improve diagnostic accuracy for gastric cancer. Sci Rep 2017 7(1):0 SCI 4.122
Alternative RNA splicing and gastric cancer Mutat Res 2017 777773(1):0 SCI 5.205
Aberrantly methylated-differentially expressed genes and pathways in colorectal cancer Cancer Cell Int. 2017 17(75):0 SCI 3.96
Post-transcriptional Regulation Of Genes Related To Biological Behaviors Of Gastric Cancer By Long Noncoding RNAs And MicroRNAs J Cancer. 2017 8(19):0 SCI 3.249
Single nucleotide polymorphisms and cancer susceptibility Oncotarget 2017 8(66):0 SCI 5.168
Differential Proteomic Analysis Reveals Protein Networks and Pathways that May Contribute to Helicobacter pylori FKBP-Type PPIase-Associated Gastric Diseases. Proteomics Clin Appl. 2017 12(3):0 SCI 3.567
SNP–SNP interactions of DNA repair gene ERCC5 with metabolic gene GSTP1 in the gastric cancer/atrophic gastritis risk modified by H. pylori infection in a Chinese population World J Gastroenterol. 2017 24(5):0 SCI 3.3
Expression of claudin-11, -23 in different gastric tissues and its relationship with the risk and prognosis of gastric cancer. PLoS One. Plos One 2017 12(3):0 SCI 2.766
A systematic review and meta-analysis of the association between long non-coding RNA polymorphisms and cancer risk. Mutat Res. 2017 1(771):0 SCI 5.261
A Serological Biopsy Using Five Stomach-Specific Circulating Biomarkers for Gastric Cancer Risk Assessment: A Multi-Phase Study. Am J Gastroenterol 2017 112(5):0 SCI 10.231
MiR-27a rs895819 is involved in increased atrophic gastritis risk, improved gastric cancer prognosis and negative interaction with Helicobacter pylori. Sci Rep. 2017 7(4):0 SCI 4.122
Association of Polymorphisms in three pri-miRNAs that Target Pepsinogen C with the Risk and Prognosis of Gastric Cancer. Sci Rep. 2017 7(3):0 SCI 4.122
Epistatic SNP interaction of ERCC6 with ERCC8 and their joint protein expression contribute to gastric cancer/atrophic gastritis risk. Oncotarget 2017 8(26):0 SCI 5.168
HpSlyD inducing CDX2 and VIL1 expression mediated through TCTP protein may contribute to intestinal metaplasia in the stomach. Sci Rep. 2017 7(1):0 SCI 4.259
The association between vacA or cagA status and eradication outcome of Helicobacter pylori infection: A meta-analysis. Plos One 2017 12(5):0 SCI 2.766
MMP family polymorphisms and the risk of aortic aneurysmal disease: A systematic review and meta-analysis. Clin Genet. 2017 0(0):0 SCI 3.512
Accuracy of testing for anti-Helicobacter pylori IgG in urine for H. pylori infection diagnosis: a systematic review and meta-analysis. BMJ Open. 2017 7(4):0 SCI 2.413
A Meta-Analysis of the Association between DNMT1 Polymorphisms and Cancer Risk. Biomed Res Int. 2017 2017(4):0 SCI 2.583
Association of CagA EPIYA-D or EPIYA-C phosphorylation sites with peptic ulcer and gastric cancer risks: A meta-analysis. Medicine (Baltimore) 2017 96(17):0 SCI 2.028
Promoter Polymorphism of Toll-Like Receptor 4 is Associated with a Decreased Risk of Coronary Artery Disease: A Case-Control Study in the Chinese Han Population. Med Sci Monit. 2017 2(3):0 SCI 1.894
Pri-let-7a-1 rs** polymorphism is associated with gastric cancer prognosis and might affect mature let-7a expression. Onco Targets Ther. 2016 4(9):0 SCI 1.653
Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis. Oncotarget 2016 4(1):0 SCI 5.168
SNP-SNP Interaction between TLR4 and MyD88 in Susceptibility to Coronary Artery Disease in the Chinese Han Population International Journal of Environmental R 2016 13(3):0 SCI 2.101
Polymorphisms of multiple genes involved in NER pathway predict prognosis of gastric cancer Oncotarget 2016 6(20):0 SCI 5.168
Association of nucleotide excision repair pathway gene polymorphisms with gastric cancer and atrophic gastritis risks Oncotarget 2016 7(6):0 SCI 5.168
SNP-SNP interactions of three new pri-miRNAs with the target gene PGC and multidimensional analysis of H. pylori in the gastric cancer/atrophic gastritis risk in a Chinese populati Oncotarget 2016 3(14):0 SCI 5.168
The association of six polymorphisms of five genes involved in three steps of nucleotide excision repair pathways with hepatocellular cancer risk. Oncotarget 2016 3(7):0 SCI 5.168
Serum VacA antibody is associated with risks of peptic ulcer and gastric cancer: A meta-analysis Microbial Pathogenesis 2016 99(2):0 SCI 2.009
Genetic polymorphisms of mTOR and cancer risk: a systematic review and updated meta-analysis. Oncotarget 2016 6(6):0 SCI 5.168
胃黏膜“血清学活检”与功能性消化不良 胃肠病学和肝病学杂志 2015 24(2):0 中文核心 0
Helicobacter pylori Infection Status Correlates with Serum Parameter Levels Responding to Multi-organFunctions Dig Dis Sci 2015 60(6):0 SCI 2.516
Association of IL-17A and IL-17F polymorphisms with gastric cancer risk in Asians: a meta-analysis Human Immunology 2015 76(1):0 SCI 2.127
SNP interactions of Helicobacter pylori-related host genes PGC, PTPN11, IL1B, and TLR4Comprehensive assessment of the association between miRNA polymorphisms and gastric cancer risk Mutat Res Rev Mutat Res 2015 763():0 SCI 6.213
Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study Int J Cancer 2015 136(2):0 SCI 5.085
Effect of ERCC8 tagSNPs and their association with H. pylori infection, smoking, and alcohol consumption on gastric cancer and atrophic gastritis risk Tumour Biol 2015 36(12):0 SCI 2.926
胃黏膜“血清学活检”与胃癌复发预警 胃肠病学和肝病学杂志 2015 24(2):0 中文核心 0
胃黏膜“血清学活检”临床应用现状及展望 胃肠病学和肝病学杂志 2015 24(2):0 中文核心 0
胃黏膜“血清学活检”在健康体检中的应用 胃肠病学和肝病学杂志 2015 24(2):0 中文核心 0
Expression of serum let-7c, let-7i, and let-7f microRNA with its target gene, pepsinogen C, in gastric cancer and precancerous disease Tumor Biology 2015 36(5):0 SCI 2.926
Association between promoter polymorphisms of OPN gene and cancer risk: a meta-analysis Onco Targets Ther 2015 9(8):0 SCI 2.272
Polymorphic rs** and rs** upregulate PGC transcription and protein expression in overdominant or dominant models Mocular Carcinogenesis 2015 4(7):0 SCI 4.722
Association of MTOR and AKT Gene Polymorphisms with Susceptibility and Survival of Gastric Cancer. Plos One 2015 10(8):0 SCI 3.057
Expression of the E-cadherin/β-catenin/tcf-4 Pathway in Gastric Diseases with Relation to Helicobacter pylori Infection: Clinical and Pathological Implications Asian Pac J Cancer Prev 2014 15(1):0 SCI 2.514
Association between Abnormal Gastric Function Risk and Helicobacter pylori Infection Assessed by ELISA and 14C-Urea Breath Test Diagnostic Microbiology and Infectious D 2014 80(4):0 SCI 2.457
Expression of XPG protein in the development, progression and prognosis of gastric cancer Plos one 2014 9(9):0 SCI 3.234
Serum OPN expression for identification of gastric cancer and atrophic gastritis and its influencing factors Plos one 2014 9(12):0 SCI 3.234
PGC TagSNP and its interaction with H. pylori and relation with gene expression in susceptibility to gastric carcinogenesis Plos One 2014 9(12):0 SCI 3.234
NOD2 polymorphisms associated with cancer risk: a meta-analysis Plos One 2014 9(2):0 SCI 3.234
Association between PTEN gene IVS4 polymorphism and risk of cancer: a meta-analysis Plos One 2014 9(6):0 SCI 3.234
Serum anti-Helicobacter pylori immunoglobulin G titer correlates with grade of histological gastritis, mucosal bacterial density, and levels of serum biomarkers Scand J Gastroenterol 2014 49(3):0 SCI 2.361
Associations of ERCC4 rs** polymorphism with cancer risk: an updated meta-analysis Asian Pac J Cancer Prev 2014 15(18):0 SCI 2.514
Host genetic factors respond to pathogenic step-specific virulence factors of Helicobacter pylori in gastric carcinogenesis Mutation Research-Reviews in Mutation 2014 759(1-3):0 SCI 6.213
A New Polymorphism Biomarker rs629367 Associated with Increased Risk and Poor Survival of Gastric Cancer in Chinese by Up-Regulated miRNA-let-7a Expression Plos one 2014 9(4):0 SCI 3.234
Nucleotide excision repair related gene polymorphisms and genetic susceptibility, chemotherapeutic sensitivity and prognosis of gastric cancer Mutation Research 2014 765(1-3):0 SCI 3.68
A comprehensive evaluation of fasting serum gastrin-17 as a predictor of diseased stomach in Chinese population Scand J Gastroenterol 2014 49(10):0 SCI 2.361

著作(近5年)
专著名称 出版社 出版年 承担职务 主编人数
《胃功能血清学检测的基础与临床》 科学出版社 2019 主编 1

专利(近5年)
专利名称 专利类别 获得年 负责人排序
暂无

科研奖励(近5年)
奖励名称 奖励级别 获奖年 负责人排序
辽宁医学奖二等奖 二等奖 2014 1
辽宁省科技进步奖二等奖 二等奖 2014 1