基本信息
姓名：
何韶衡导师类别：
博导
性别：
男出生年月：
195704
学术职称：
教授业务职称：
无
最后学位：
境外学位

院系：
基础医学院
科室：
免疫学教研室
办公电话：

电子邮箱：
shoahenghe@hotmail.com

  研究方向

博士研究方向为：过敏性疾病发病机制及临床诊治新策略
硕士研究方向为：过敏性疾病发病机制及临床诊治新策略/学术学位



  教育经历

时间就读院校所获学位专业名称
1978.2-1982.8哈尔滨医科大学医疗系医学学士学位临床医学专业
1985.8-1986.5美国俄克拉荷马州中州大学学历教育访问学者
1993.7-1996.1英国南安普顿大学医学院医学博士学位免疫药理学专业


  工作经历

时间工作单位承担职务从事工作
1999.7-2001.8英国南安普顿大学医学院高级研究员、博士生导教学、科研、管理
2001.1-2006.5汕头大学医学院“****”特聘教授教学、科研、管理
2006.6-2013.1南京医科大学第一附属医院博导，临床实验研究中教学、科研、管理


  社会任职

    中华医学会变态反应学分会常委；中国协和医科大学，客座教授；英国过敏及临床免疫学会会员；英国过敏学会会员；Lead guest editor of Mediators of Inflammation;国家“973”项目复审专家组成员；国家自然科学基金委员会，第十届生命科学部专家评审组成员；《中国病理生理杂志》编委；免疫学杂志编委；《中华医学百科全书》变态反应学卷副主编；第十届中国药理学会抗炎免疫药理学专业委员会委员；《中华临床免疫和变态反应杂志》编委


  荣誉称号

    英国南安普顿大学超聘一级工资的奖励;英国皇家学会奖励;广东省科技进步一等奖;江苏省“333高层次人才培养工程”中青年科技领军人才;广东省科技进步三等奖;海南省科技进步二等奖;入选Who’s Who in the World（世界名人录2009,2010）; “十一五”期间江苏省优秀重点人才;江苏省第三期“333工程”突出贡献奖; 南京医科大学“十一五”期间科研工作先进个人; 江苏省人民医院第六次科技人才与科技工作会议先进个人。


  承担课题

时间课题名称下达部门课题经费
201101-201412干扰素-lambda对过敏原诱导的肥大细胞Toll样受体表达和细胞因子分泌的调节国家自然科学基金委员会185万元
201201-201512美洲大蠊主要过敏原的鉴定及其活化树突状细胞、肥大细胞的机制研究国家自然科学基金委员会52万元
201301-201512辽宁省高等学校攀登学者辽宁省教育厅150万元
201301-201612变态反应学基础研究创新团队项目中央财政支持地方高校发展专项资金项目1000万元
201301-201712免疫识别、免疫调节与免疫相关性疾病发生和干预的基础研究国家科技部90万元
201301-201712杨树、悬铃木等人体易过敏树种低致敏新品种选育研究国家林业局133万元
201401-201612过敏性疾病早期诊断及治疗技术研究国家科技部332万元
201401-201612过敏性疾病的发病机制研究辽宁省教育厅100万元
201501-201812过敏原特异性IgG受体介导的肥大细胞脱颗粒的特点及其机制研究国家自然科学基金委员会65万元
201501-201812辽宁省高校重大科技平台---辽宁省炎症与创伤诊治工程技术研究中心辽宁省教育厅2000万元


  学术论文

文章题目杂志名称发表年卷期页
Targeted NF-kappaB inhibition of asthmatic serum-mediated human monocyte-derived dendritic cell differentiation in a transendothelial trafficking modelCell Immunol**(1):14
Downregulation of Protease Activated Receptor Expression and Cytokine Production in P815 Cells by RNA InterferenceBMC Cell Biol200910():
Expression of integrin alphavbeta 6 in the intestinal epithelial cells of patients with inflammatory bowel diseaseN Am J Med Sci20091(4):200
Glucuronoxylomannan promotes the generation of antigen-specific T regulatory cell that suppresses the antigen specific Th2 response upon activationJ Cell Mol Med200913(8B):1765
Development and characterization of a rat model of chronic obstructive pulmonary disease (COPD) induced by sidestream cigarette smokeToxicol Lett**(3):225
Induction of IL-4 release and upregulated expression of protease-activated receptor by GM-CSF in p815 cellsCytokine200948(3):196
Purification, characterization and biological activities of the L-amino acid oxidase from Bungarus fasciatus snake venomToxicon200954(3):262
Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2BMC Immunol200910():
High Adiponectin and Adiponectin Receptor 1 Expression in Synovial Fluids and Synovial Tissues of Patients with Rheumatoid ArthritisSemin Arthritis Rheu200938(6):420
Upregulation of Toll-like receptor (TLR) expression and release of cytokines from P815 mast cells by GM-CSFBMC Cell Biology200910():
Integrative genomic analyses on interferon-lambdas and their roles in cancer predictionInt J Mol Med201025(2):299
Methods for protein identification using expressed sequence tags and peptide mass fingerprinting for seed crops without complete genome sequencesSeed Science Research**(20):257
Specific immunotherapy suppresses Th2 responses via modulating TIM1/TIM4 interaction on dendritic cellsAllergy201065(8):986
Identification of a novel mutation in the DSRAD gene in a Chinese family with dyschromatosis symmetrica hereditariaJ Am Acad Dermatol201063(3):529
Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29Allergy201065(10):1234
Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytesInt J Mol Med201025(2):257
Unusual life-threatening Rosai-Dorform disease of the trachea: role of NF-KβThorax201065(10):927
Analysis of patents on anti-allergic therapies issued in China from 1988 to 2008Expert Opin Ther Pat201020(6):727
Induction of microvascular leakage and histamine release by promutoxin, an Arg49 phospholipase A2Toxicon201055(4):888
Analysis of trends and opportunities of anti-allergy patents in China from 1998 to 2008Recent Pat Inflamm Allergy Drug Discov20104(2):130
Upregulation of Toll-like Receptor (TLR) Expression and Release of Cytokines from Mast Cells by IL-12Cell Physiol Biochem201026(3):337
Induction of inflammatory cell accumulation by TM-N49 and promutoxin, two novel phospholipase A(2)Toxicon201056(4):580
TNF increases expression of IL-4 and PARs in mast cellsCell Physiol Biochem201026(3):327
Induction of IL-13 production and upregulation of gene expression of protease activated receptors in P815 cells by IL-6Cytokine201050(2):138
Altered signaling gene expression in Jurkat cells upon FTY720 induced apoptosisInt J Mol Sci201011(9):3087
CD14+ cell-derived IL-29 modulates proinflammatory cytokine production in patients with allergic airway inflammationAllergy201166(2):238
Induction of IL-13 production and upregulated expression of protease activated receptor-1 by RANTES in a mast cell lineCytokine201153(2):231
Interferon Lambda Mediates Oral Tolerance and Inhibits Antigen-Specific, T-Helper 2 Cell-Mediated Inflammation in Mouse IntestineGastroenterology**(1):249
Analysis of properties and proinflammatory functions of cockroach allergens Per a 1.01sScand J Immunol201174(3):288
Tryptase enzyme activity is correlated with severity of chronic obstructive pulmonary diseaseTohoku J Exp Med**(3):179
A novel allergen Tab y 1 with inhibitory activity of platelet aggregation from salivary glands of horsefliesAllergy201166(11):1420
Increased interleukin (IL)-8 and decreased IL-17 production in chronic obstructive pulmonary disease (COPD) provoked by cigarette smokeCytokine201156(3):717
IL-9+IL-10+ T cells link immediate allergic response to late phase reactionClin Exp Immunol**(1):29
Eosinophil-derived interferon-lambda contributes to initiation of allergen-related inflammation in the intestineCytokine201258(2):186
Cockroach Allergen per a 7 Down-Regulates Expression of Toll-Like Receptor 9 and IL-12 Release from P815 Cells Through PI3K and MAPK Signaling PathwaysCell Physiol Biochem201229(3-4):56
IFN-λ inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral productionAntiviral Res201295(1):57
Analysis of antibiotic patents issued in China from 1992 to 2011Expert Opin Ther Pat201222(10):1205
An update on anti-allergic patents granted in China: 2009 -2011Expert Opin Ther Pat201222(73):715
Mast Cell Tryptase Induces Microglia Activation via Protease-activated Receptor 2 SignalingCell Physiol Biochem201229(5-6):931
Self-amplification mechanisms of mast cell activation: a new look in allergyCurr Mol Med.**(10):1329
A unique life-threatening mediastinal liposarcoma mimicking pleural effusionAm J Respir Crit Care Med**(1):57
Purification and Characterization of Two New Allergens from the Venom of Vespa magnificaPLoS One20127(2):8
Induction of Mast Cell Accumulation by Promutoxin, An Arg-49 Phospholipase A2Biomed Res Int**():
Mast cells and basophils are essential for allergies: mechanisms of allergic inflammation and a proposed procedure for diagnosis.Acta Pharmacol Sin201334(10):1270
Modulation of PAR expression and tryptic enzyme induced IL-4 production in mast cells by IL-29Cytokine201361(2):469
Activation of protease-activated receptor 2-mediated signaling by mast cell tryptase modulates cytokine production in primary cultured astrocytesMediators of inflamm**():
Induction of Tumor Necrosis Factor (TNF) Release from Subtypes of T cells by Agonists of Proteinase Activated ReceptorsMediators of inflamm**():
Cockroach allergen Bla g 7 promotes TIM4 expression in dendritic cells leading to Th2 polarizationMediators of inflamm**():
Subsets of regulatory T cells and their roles in allergyJ of Transl Med201412(125):
Preparation and identification of Per a 5 as a novel American cockroach allergenMediators of inflamm**():
Actions of allergens and mediators in allergyMediators Inflamm**():
Evaluation on potential contributions of protease activated receptors (PARs) related mediators in allergic inflammationMediators Inflamm**():


  著作/专利

专著名称出版社出版年承担职务
《基础过敏反应学》科学出版社主编2009
《实验过敏反应学》科学出版社主编2010
一种在杆状病毒-昆虫表达系统中生产美洲大蠊过敏原蛋?/td>5项专利第一发明人2011
《临床过敏疾病学》科学出版社主编2012


  科研奖励

奖励名称奖励级别获奖年负责人排序
广东省科技进步三等奖省部级20091
海南省科技进步二等奖省部级20112
江苏省第三期“333工程”突出贡献奖省部级20111
“十一五”期间江苏省优秀重点人才省部级20111


  研究生就业

谢华，女，沈阳军区总医院呼吸内科主任医师，教授， 硕导。陶爱林，男，广州医科大学附属二院，教授，博导。魏继福，男，南京医科大学第一附属医院，教授，博导。陈章权，男，广东医学院，教授，硕导。张慧云，女，辽宁医学院病理生理教研室主任，教授，硕导。王海燕，女，汕头大学医学院，副教授。李涛，男，汕头大学附属医院，副主任医师。王莉，女，汕头大学附属医院皮肤科，主任医师，教授，硕导。林青，男，美国约翰霍普金斯大学，研究员。王顺兰，女，海口市人民医院中心实验室，助理研究员。马文静，南京医科大学第一附属医院，助理研究员。