基本信息
姓名：
彭亮导师类别：
博导
性别：
女出生年月：
195906
学术职称：
教授业务职称：
无
最后学位：
医学博士学位

院系：
代谢病分子机制与药物研究所
科室：
代谢病所
办公电话：
**-5130
电子邮箱：
lpeng@mail.cmu.edu.cn

研究方向

博士研究方向为：神经药理学，分子神经生物学，分子神经细胞
硕士研究方向为：神经药理学，分子神经生物学，分子神经细胞/学术学位
硕士研究方向为：神经药理学，分子神经生物学，分子神经细胞/专业学位



教育经历

时间就读院校所获学位专业名称
197809-198309中国医科大学医学学士学位临床医学
198809-199412加拿大Saskatchewan医学博士学位药理学


工作经历

时间工作单位承担职务从事工作
199709-200006美国加州NeoTherapeutics药物公司研究员科研
200008-200208中国香港基因芯片公司实验室主任科研
200303-至今中国医科大学教授教学、科研


荣誉称号

2011年-2012年，辽宁省友谊奖 2012年，沈阳市玫瑰奖


承担课题

时间课题名称下达部门课题经费
200801-201012氟西汀调节星形胶质细胞5-HT2B受体的药物作用机制-RNA编辑国家自然科学基金委员会30万元
200801-201012有关肝功能衰竭中枢神经系统并发症治疗的基础理论研究国家自然科学基金委员会45万元
201201-201512有关氟西汀作用的新探讨：星形胶质细胞脂阀的调节国家自然科学基金委员会62万元


学术论文

文章题目杂志名称发表年卷期页
Down-regulation of gene expression of the kainate receptor GluK2 (GluR6) by chronic treatment with anti-bipolar drugs in cultured astrocytes and brain.Neuropharmacology200957():375-385
ERK phosphorylation in intact, adult brain by alpha2-adrenergic transactivation of EGF receptors.Neurochemistry Int.200955():593-600
Chronic treatment of astrocytes with fluoxetine enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation.Psychopharmacology**():1-12
Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc-.Toxicol Appl Pharmaco.**():209-223
Ouabain binding kinetics and FXYD7 expression in astrocytes and neurons in primary cultures: implications for cellular contributions to extracellular K+ homeostasis?Neuron Glia Biol.20106():127-135
Serotonin increases ERK1/2 phosphorylation in astrocytes by stimulation of 5-HT2B and 5-HT2C receptors.Neurochem Int.201057():432-439
5-HT2B receptors are expressed on astrocytes from brain and in culture and are a chronic target for all five conventional 'serotonin-specific reuptake inhibitors'.Neuron Glia Biol.20106():113-125
Astrocytic transactivation by alpha(2)-adrenergic and 5-HT2B serotonergic signaling.Neurochem Int.201057():421-431
Signaling pathways of isoproterenol-induced ERK1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent.J Neurochem.**():1007-1023
Increased Na, K-ATPase alpha2isoform gene expression by ammonia in astrocytes and in brain in vivo.Neurochem Int.201057():395-403
Effects of chronic treatment with fluoxetine on receptor-stimulated increase of [Ca2+]i in astrocytes mimic those of acute inhibition of TRPC1 channel activity.Cell Calcium201150():42-53
Fluoxetine Affects GluK2 Editing and Glutamate-Evoked Ca2+ Influx and ERK Phosphorylation in Mouse Astrocytes.Journal of Psychiatry & Neuroscience201136():322-338
Astrocyte ERK phosphorylation precedes K+-induced swelling but follows hypotonicity-induced swelling.Neuropathology201131():250-264
Astrocytes as a 5-HT2B-Mediated SSRI, SERT-independent target, slowly altering depression-associated genes and function.Curr Signal Transduct Ther20127():65-80
Adrenergic and V1-ergic agonists/antagonists affecting recovery from brain trauma in the lund project act on astrocytes.Curr Signal Transduct Ther.20127():43-55
Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes.Neurochem Int.201261():1325-1332
Chronic Treatment with Anti-bipolar Drugs Causes Intracellular Alkalinization in Astrocytes, Altering Their Functions.Neurochem Res.201237():2524-2540
Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH.Neurochem Int.201261():187-194
Does conventional anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function?Pharmacol Biochem Behav.**():712-725
Astrocytic and neuronal accumulation of elevated extracellular K+ with a 2/3 K+/Na+ flux ratio-consequences for energy metabolism, osmolarity and higher brain functionFront Comput Neurosci.20137():114
Expression of nucleoside transporter in freshly isolated neurons and astrocytes from mouse brain.Neurochem Res.201338():2351-2358
Comparison between drug-induced and K+-induced changes in molar acid extrusion fluxes (JH⁺) and in energy consumption rates in astrocytes.Neurochem Res.201338():2364-2374
Cell-Specific mRNA Alterations in Na+,K+-ATPase α and β Isoforms and FXYD in Mice Treated Chronically with Carbamazepine, an Anti-Bipolar Drug.Neurochem Res.201338():834-841
Importance of ‘inflammatory molecules’, but not necessarily of inflammation, in the pathophysiology of bipolar disorder and in the mechanisms of action of anti-bipolar drugs.Neurology, Psychiatry and Brain Research201319():174-179
Brain glycogenolysis, adrenoceptors, pyruvate carboxylase, Na+,K+-ATPase and Marie E. Gibbs' pioneering learning studies.Front Integr Neurosci.20137():20
Mechanisms for L-channel-mediated increase in [Ca2+]i and its reduction by anti-bipolar drugs in cultured astrocytes combined with its mRNA expression in freshly isolated cells...Cell Calcium201354():335-342
Requirement of glycogenolysis for uptake of increased extracellular k+ in astrocytes: potential implications for k + homeostasis and glycogen usage in brain.Neurochem Res.201338():472-485
Ammonia-induced Na,K-ATPase/ouabain-mediated EGF receptor transactivation, MAPK/ERK and PI3K/AKT signaling and ROS formation cause astrocyte swelling.Neurochem Int.201363():610-625
When can AQP4 assist transporter-mediated K⁺ uptake?J Gen Physiol.**():87-89
Chronic fluoxetine administration increases expression of the L-channel gene Cav1.2 in astrocytes from the brain of treated mice and in culture and augments K+ induced increase in.Cell Calcium201456():166-174
Basic mechanism leading to stimulation of glycogenolysis by isoproterenol, EGF, elevated extracellular K(+) concentrations, or GABA.Neurochem Res.201439():661-667
Role of the intracellular nucleoside transporter ENT3 in transmitter and high K(+) stimulation of astrocytic ATP release investigated using siRNA against ENT3. ,ASN neuro20146():175909
Signal transduction in astrocytes during chronic or acute treatment with drugs (SSRIs, antibipolar drugs, GABA-ergic drugs, and benzodiazepines) ameliorating mood disorders.Journal of signal transduction**():5939
Fluoxetine and all other SSRIs are 5-HT2B agonists - importance for their therapeutic effectsCurrent neuropharmacology201412(): 365-379
Ammonium increases Ca(2+) signalling and up-regulates expression of TRPC1 gene in astrocytes in primary cultures and in the in vivo BrainNeurochemical research201439():2127-2135
Role of glycogenolysis in stimulation of ATP release from cultured mouse astrocytes by transmitters and high K+ concentrations.ASN Neuro.20146():e00132
Glycogenolysis and purinergic signaling. Advances in neurobiology201411():31-54
Ammonia, Like K, Stimulates the Na, K , 2 Cl Cotransporter NKCC1 and the Na ,K -ATPase and Interacts with Endogenous Ouabain in Astrocytes. Neurochemical research201440():241-57
Chronic SSRI stimulation of aastrocytic 5-HT2B receptors change multiple gene expression/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift.Frontiers in Behavioral Neuroscience20159():25
Role of the Astrocytic Na+,K+-ATPase in K+ Homeostasis in Brain: K+ Uptake, Signaling Pathways and Substrate Utilization.Neurochemical Reserch2015Jan 3():Epub ahea
Ammonium increases Ca2+ signalling and up-regulates expression of Cav1.2 gene in astrocytes in primary cultures and in the in vivo brain.Acta Physiologica201539():2127-35
Fluoxetine induces alkalinizationof astroglial cytosol through stimulation of sodium-hydrogen exchanger 1: Dissection of intracellular signalling pathways.Frontiers in Cellular Neuroscience20159():61
Cell type-specific in vivo expression of genes encoding signalling molecules in the brain in response to chronic mild stress and chronic treatment with fluoxetine.Psychopharmacology（Berlin）**():2827-35
Chronic treatment with anti-bipolar drugs suppresses glutamate release from astroglial cultures.Amino Acids201547():1045-51


研究生就业

毕业研究生24名，其中16人获得博士学位， 8人获得硕士学位。 11人在医学院校任职（其中4人留任中国医科大学），6人从事医疗工作，其余7名从事医药研发工作。