基本信息
姓名：
皮静波导师类别：
博导
性别：
男出生年月：
196603
学术职称：
教授业务职称：
无
最后学位：
理学博士学位

院系：
公共卫生学院
科室：
卫生毒理学教研室
办公电话：
**
电子邮箱：
jpi@mail.cmu.edu.cn

研究方向

博士研究方向为：氧化应激的健康效应及机制研究
硕士研究方向为：氧化应激的健康效应及机制研究/学术学位
硕士研究方向为：氧化应激的健康效应及机制研究/专业学位



教育经历

时间就读院校所获学位专业名称
198509-199007中国医科大学医学学士学位预防医学
199209-199507中国医科大学医学硕士学位劳动卫生与职业病
199803-200202日本筑波大学医学博士学位环境生态


工作经历

时间工作单位承担职务从事工作
200203-200605美国国立健康研究院、哈姆纳健康研究院博士后科研
200606-201308美国哈姆纳健康研究院助理研究员、副研究员科研
201309-至今中国医科大学教授科研与教学


社会任职

现任美国毒理学会-干细胞分会主席，美国East Carolina University毒理药理学系博士学位指导及答辩委员会成员，美国华人糖尿病学会终身会员，美国自由基生物学和医学学会、美国糖尿病学会科技会、美国毒理学会和美国华人毒理学会会员。 担任Toxicology and Applied Pharmacology副主编，Journal of Public Health、Chemical Research in Toxicology、ISRN Toxicology编委，Oxidative Medicine and Cellular Longevity专刊客座主编。
荣誉称号

2013年，辽宁高等学校攀登学者。


承担课题

时间课题名称下达部门课题经费
201311-201612科研启动经费中国医科大学150万元
201401-201712辽宁高等学校攀登学者辽宁省教育厅150万元
201401-201612辽宁省高端人才“十百千”百人辽宁省教育厅100万元


学术论文

文章题目杂志名称发表年卷期页
Dose-dependent transitions in Nrf2-mediated adaptive response and related stress responses to hypochlorous acid in mouse macrophagesToxicol Appl Pharmacol**(1):27-36
Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell functionEndocrinology**(7):3040-3048
ROS and UCP2 in pancreatic β-cell functionDiabetes Obes Metab201012S2():141-148
Arsenic impairs glucose-stimulated insulin secretion in pancreatic beta-cells: involvement of Nrf2-mediated antioxidant responseEnviron Health Perspect**(6):864-870
ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell functionToxicol Appl Pharmacol**(1):77-83
Nrf2 in toxicology and pharmacology: the good, the bad and the ugly?Toxicol Appl Pharmacol**(1):1-3
Deficiency in the nuclear factor E2-related factor-2 transcription factor results in impaired adipogenesis and protects against diet-induced obesityJ Biol Chem**(12):9292-9300
Long isoforms of NRF1 contribute to arsenic-induced antioxidant response in human keratinocytesEnviron Health Perspect**(1):56-62
Prolonged inorganic arsenite exposure suppresses insulin-stimulated AKT S473 phosphorylation and glucose uptake in 3T3-L1 adipocytes: involvement of the adaptive antioxidant responBiochem Biophys Res Commun**(2):360-365
Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesisFree Radic Biol Med201252(2):462-472
Deficiency in the nuclear factor E2-related factor 2 renders pancreatic β-cells vulnerable to arsenic-induced cell damageToxicol Appl Pharmacol**(3):315-323
Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cellsFree Radic Biol Med201253(4):758-768
Cross-regulations among NRFs and KEAP1 and effects of their silencing on arsenic-induced antioxidant response and cytotoxicity in human keratinocytesEnviron Health Perspect**(4):583-589
Association between arsenic suppression of adipogenesis and induction of CHOP10 via the endoplasmic reticulum stress responseEnviron Health Perspect**(2):237-243
Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytesToxicol Appl Pharmacol**(3):435-441
Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndromeDiabetes201362(3):845-854
Divergent effects of sulforaphane on basal and glucose-stimulated insulin secretion in β-cells: role of reactive oxygen species and induction of endogenous antioxidantsPharm Res201330(9):2248-2259
Keap1 silencing boosts lipopolysaccharide-induced transcription of interleukin 6 via activation of nuclear factor κB in macrophagesToxicol Appl Pharmacol**(3):697-702


著作/专利

专著名称出版社出版年承担职务
Nrf2 in Toxicology and PharmacologyElsevier责任客座主编2010
Compositions for modulating Nrf2 activity and thei美国专利号：US61/847630第一负责人2013
NRF2-ARE inhibitors, compositions for modulating N美国专利号：US61/891956第一负责人2013
Systems biology of free radicals and anti-oxidantsSpringer-Verlag Berlin HeidelbergBook chapter2014


研究生论文
研究生获奖
研究生就业