于英华
博士生导师

职称：教授
**

学院：基础医学院
@qq.com







个人简介
于英华，博士，教授，博士生导师。研究领域：肠道微生态与慢性代谢性疾病及神经退行性疾病的发病和干预治疗机制。先后主持澳大利亚国家健康和医疗研究理事会（NHMRC）、澳大利亚糖尿病协会研究信托基金（Diabetes Australia Research Trust）、澳大利亚伍伦贡大学研究基金、国自然面上项目、江苏省高等学校自然科学研究重大项目等项目7项。发表SCI论文62篇。以第一作者或通讯作者在Microbiome（一区，IF 12.16）、Obesityreview（一区，IF 8.48）等杂志发表SCI论文21篇，其中中科院一区论文5篇。指导博士生13名，硕士生13名。


【主持课题】
1.国家自然科学基金面上项目，**，PTP1B调控小胶质细胞糖代谢重编程及M1极化在饮食诱导认知功能障碍中的作用机制研究，55万，2021-2024，主持，在研。
2.国家自然科学基金面上项目，**，PTP1B抑制Lepr-JAK2-GSK3β信号通路在肥胖诱导认知障碍中的作用及机制研究，56万，2019-2022，主持，在研。
3.江苏********项目，200万，2017-2020，主持，在研。
4. 澳大利亚国家健康和医疗研究理事会（NHMRC）研究员项目 (NHMRC training fellowship) 2009-2013, 功能性营养分子对于摄食和体重的调控, ID 573441, $341,768澳币. 主持，结题
5. 澳大利亚糖尿病协会研究信托基金项目2012, 不同种脂肪酸对于肥胖和二型糖尿病中瘦素敏感性和糖耐量异常的不同影响，$60,000澳币. 主持，结题
6. 伍伦贡大学科研理事会项目2012, 脂肪酸对于下丘脑瘦素信号的调节，$12,031澳币. 主持，结题
7. 工业项目, Clover Corporation ltd, Australia 新型脂肪酸对于早产儿免疫调节2014-217， $330,000澳币. 参与，结题


【代表性论文】
1.Hongli Shi,Yinghua Yu*, Danhong Lin, Peng Zheng, Peng Zhang, Minmin Hu, Qiao Wang, Wei Pan, Xiaoying Yang, Tao Hu1, Qianqian Li, Renxian Tang, Feng Zhou1, Kuiyang Zheng*, Xu-Feng Huang* β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice. Microbiome. 2020,8, Article number: 143（IF: 12.16，JCR一区）*通讯作者
2.Hongli Shi; Qiao Wang; Mingxuan Zheng; Shanshan Hao; Jeremy S. Lum; Xi Chen; Xu-Feng Huang;Yinghua Yu*,Kuiyang Zheng* (2020). Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice. Journal of Neuroinflammation. 17(1): p. 77..（IF: 5.7，JCR一区）*通讯作者
3.Chen Xiaoqi,Yu Yinghua*, Zheng Peng, Jin Tiantian, He Meng,Zheng Mingxuan, Song Xueqin, Jones Alison, Huang Xu-Feng*(2020). Olanzapine increases AMPK-NPY orexigenic signaling by disrupting H1R-GHSR1a interaction in the hypothalamic neurons of mice. Psychoneuroendocrinology, 114, 104594.（IF:4.03，JCR一区）*通讯作者
4.Yinghua Yu,Craig Patch, Katrina Weston-Green, Yuan Zhou, Kuiyang Zheng and Xu-Feng Huang (2018) Dietary galacto-oligosaccharides and resistant starch protect against altered CB1 and 5-HT1A and 2A receptor densities in rat brain: Implications for preventing cognitive and appetite dysfunction during a high-fat diet. Molecular Nutrition and Food Research. 62(21):e**.（IF:5.151，JCR一区）Impact factor: 5.151.
5.Yi Liu*,Yuyun Zhang,Xian Zheng,Tongyong Fang,Xia Yang,Xuan Luo,Anlei Guo,Kelly A. Newell,Xu-Feng Huang,Yinghua Yu*(2018) Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice. Journal of Neuroinflammation. 2018,15(1):112（IF: 5.7，JCR一区）*通讯作者
6.Xu-Feng Huang, Katrina Green,Yinghua Yu*,(2017) Decreased 5-HT2cR and GHSR1a interaction in antipsychotic drug-induced obesity. Obesity Reviews. 19(3): 396~405.（IF:8.483，JCR一区）*通讯作者


【联系邮箱】： Email: @qq.com

论文情况（近五年）


科研项目（近五年）





发表论文:
β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice

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DHA reduces hypothalamic inflammation and improves central leptin signaling in mice.

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Supplement of microbiota-accessible carbohydrates prevents neuroinflammation and cognitive decline by improving the gut microbiota-brain axis in diet-induced obese mice.

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Curdlan Prevents the Cognitive Deficits Induced by a High Fat Diet in Mice via the Microbiota-Gut-Brain Axis.

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Oat derived β-glucans induced trained immunity through metabolic reprogramming.

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HIV-1 Tat enhances purinergic P2Y4 receptor signaling to mediate inflammatory cytokine production and neuronal damage via PI3K/Akt and ERK MAPK pathways

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Olanzapine increases AMPK-NPY orexigenic signaling by disrupting H1R-GHSR1a interaction in the hypothalamic neurons of mice.

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Dietary galacto-oligosaccharides and resistant starch protect against altered CB1 and 5-HT1A and 2A receptor densities in rat brain: Implications for preventing cognitive and appetite dysfunction duri

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Galantamine improves cognition, hippocampal inflammation, and synaptic plasticity impairments induced by lipopolysaccharide in mice

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Decreased 5-HT2cR and GHSR1a interaction in antipsychotic drug-induced obesity
教材专著:
实用中西医结合临床系列
科研项目:
PTP1B调控小胶质细胞糖代谢重编程及M1极化在饮食诱导认知功能障碍中的作用机制研究

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国自然面上

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江苏省特聘教授
获奖成果:
愈肾颗粒治疗儿童紫癜性肾炎 (HS