闫居明
博士生导师

职称：教授

学院：基础医学院
jumingyan@xzhmu.edu.cn

https://www.researchgate.net/profile/Yan-Juming






个人简介
闫居明，教授，博士生导师。现任职于徐州医科大学江苏省免疫与代谢重点实验室。2013年获得中国科学院大学硕士学位，2019年获得澳大利亚昆士兰大学博士学位。近五年以第一作者在Cancer Discovery，Cancer Immunology Reserch等著名期刊发表学术文章5篇；以共同作者在Nature Immunology，Cancer Discovery，Oncogene等期刊发表学术论文18篇。论文被引700余次。澳大利亚免疫学会会员，Journal of Immunology Research期刊Guest editor。作为肿瘤免疫与代谢课题组PI带领研究团队主要致力于1）巨噬细胞、MAIT细胞和代谢型谷氨酸受体对肿瘤微环境调控机制及其在免疫疗中的作用；2）小分子化合物的免疫调节作用及其抑制肿瘤的机制，探索恶性肿瘤发病机制、预警靶标和药物靶点。




发表论文:
The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation

---

Control of metastases via myeloid CD39 and NK cell effector function

---

MAIT Cells Promote Tumor Initiation, Grow and Metastases via Tumor MR1

---

Infiltrating Myeloid Cells Drive Osteosarcoma Progression via GRM4 Regulation of IL23

---

Timing of neoadjuvant immunotherapy in relation to surgery is crucial for outcome

---

B591, a novel specific pan-PI3K inhibitor, preferentially targets cancer stem cells

---

IL-23 promotes the development of castration-resistant prostate cancer

---

Deficiency of host CD96 and PD-1 or TIGIT enhances tumor immunity without significantly compromising immune homeostasis

---

Experimental lung metastases in mice are more effectively inhibited by blockade of IL23R than IL23

---

Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells
教材专著:

科研项目:

获奖成果: