刘相叶
硕士生导师

职称：副教授

学院：基础医学院
liuxy83@xzhmu.edu.cn







个人简介
刘相叶，男，1983年9月生，九三学社社员，法国巴黎东大学生物学博士，副教授，硕士研究生导师，江苏省高校“青蓝工程”优秀青年骨干教师，苏北发展特聘专家，中国免疫学会会员。现就职于徐州医科大学基础医学院病原生物学与免疫学教研室，主讲《人体寄生虫学》课程。主要研究领域为肿瘤发病机制与肿瘤干细胞，主持国家自然科学基金、江苏省自然科学基金、中国博士后基金等各级各类基金5项；在国内外重要期刊发表论文20余篇，其中SCI收录论文14篇。目前担任Frontiers in Veterinary Science、Infectious Diseases of Poverty、PLoS One等5本国际期刊的审稿人。指导硕士研究生2人，指导本科生成功申报国家级科技创新计划项目3项，指导本科生获第四、五届全国大学生基础医学创新论坛暨实验设计大赛三等奖。


【教育经历】
2009/12-2013/12，法国巴黎东大学，生物学博士
2006/09-2009/07，吉林大学，预防兽医学硕士
2002/09-2006/07，山东农业大学，动物医学学士


【人才称号】
1.江苏省高校“青蓝工程”优秀青年骨干教师，江苏省教育厅，2019
2.苏北发展特聘专家，江苏省委组织部/人力资源和社会保障厅，2016


【学术任职】
1.2016.09-至今，中国免疫学会会员
2.2018.10-至今，中国抗癌协会会员


【主持/参与课题】
1.江苏省高校“青蓝工程”优秀青年骨干教师，江苏省教育厅，2019-2021，4万元，主持，在研；
2.国家自然科学基金青年项目，**，CRBP1调控WIF1/Wnt/β-catenin通路抑制肝癌肿瘤干细胞特性的分子机制，2019/01-2021/12，21万元，主持；
3.江苏省自然科学基金青年项目，BK**，长角血蜱传播嗜吞噬细胞无形体功能基因的筛选与研究，2015/07-2018/06，22万元，主持；
4.中国博士后基金面上项目，2015M580472，介导嗜吞噬细胞无形体传播的蜱唾液腺基因的筛选与研究，2015/11-2017/12，8万元，主持；
5.徐州医科大学引进优秀人才基金，D**，介导嗜吞噬细胞无形体传播的长角血蜱基因的筛选与研究，2015/06-2018/12，30万元，主持；
6.江苏省脑病生物信息重点实验室开放课题，JSB1402，长角血蜱传播嗜吞噬细胞无形体机制的初步研究，2014/08-2017/08，3万元，在研，主持；
7.国家级大学生创新创业训练计划，，徐州地区媒介蜱及蜱传病原的调查研究，2015/12-2017/12，2万元，指导教师；
8.欧盟EDENext基金项目，EDENext037，Identification of genes implicated in the vectorial capacity of the tickIxodes ricinus，2011-2014，3万欧元，参与；
9.法国农科院（INRA）基金项目，FP7-261504，Sequencing of the salivary glands transcriptome ofIxodes ricinus，2010/01-2010/12，4万欧元，参与。


【代表性论文】（第一/通讯作者均加粗，第一作者用“#”标出，通讯作者用“*”标出）
1.Xiangye Liu*,Huiqin Li, Hongkuan Deng, Chen Zheng, Hongru Yan, Zetian Chen, Anning Bian, Jiaxu Chen, Kuiyang Zheng,Glyceraldehyde-3-phosphate dehydrogenase ofBabesia microtiis a plasminogen- and actin-binding protein,Frontiers in Veterinary Science, 2019, 6: 228.
2.Zetian Chen,Huiqin Li,Xiaoge Gao,Anning Bian,Hongru Yan,Delong Kong,Xiangye Liu*. Human Babesiosis in China: a systematic review, Parasitology Research, 2019, 118(4):103–1112.
3.Xiaoge Gao#,Xiangye Liu#, Wenhua Shan, Qian Liu, Chao Wang, Jiwei Zheng, Hong Yao, Renxian Tang, Junnian Zheng.Anti-malarial atovaquone exhibits anti-tumor effects by inducing DNA damage in hepatocellular carcinoma, American Journal of Cancer Research, 2018, 8(9):1697-1711.
4.Xiaoge Gao, Wenhua Shan,Xiangye Liu, Jian Zhang,Junnian Zheng,Hong Yao.JNK1/2 and EKR1/2 provides vital clues about tumor recurrence and survival in hepatocellular carcinoma patients, Future Oncology, 2018, 14(24):2471-2481.
5.Hongru Yan, Anning Bian, Xiaoge Gao*, Huiqin Li, Zetian Chen,Xiangye Liu*.Novel applications for an established antimalarial drug: tumoricidal activity of quinacrine, Future Oncology, 2018,14(15):1511-1520.
6.Xiaoge Gao, Chen Zheng,Xiangye Liu*. Expression, purification, and biological characterization ofAnaplasma phagocytophilumenolase, BioScience Trends, 2107, 11(6):651-657.
7.Xiaoge Gao, Jingjie Liu,Xiangye Liu,Liantao Li, Junnian Zheng. Cleavage and phosphorylation: important post-translational modifications of galectin-3, Cancer Metastasis Review, 2017 (36):367–374.
8.Xiangye Liu*, Chen Zheng, Xiaoge Gao, Jiaxu Chen, Kuiyang Zheng*. Complete Molecular and Immunoprotective Characterization ofBabesia microtiEnolase, Frontiers in Microbiology, 2017, 8:622.
9.Xiangye Liu*, Xiangyao Gong, Chen Zheng, Qiyuan Song, Ting Chen, Jing Wang, Jie Zheng, Hongkuan Deng, Kuiyang Zheng*. Molecular epidemiological survey of bacterial and parasitic pathogens in hard ticks from eastern China, Acta Tropica, 2017 (167):26-30.
10.Elsa Léger,Xiangye Liu, Sébastien Masseglia, Valérie No?l, Gwena?l Vourc'h, Sarah Bonnet, Karen D McCoy. Reliability of molecular host-identification methods for ticks: an experimental in vitro study withIxodes ricinus.Parasites & vectors, 2015, 8: 433.
11.Xiangye Liu, José de la Fuente, Martine Cote, Galindo C Ruth, Moutailler Sara, Muriel Vayssier-Taussat, Sarah I Bonnet. IrSPI, a tick serine protease inhibitor involved in tick feeding andBartonella henselaeinfection. PLoS Neglected Tropical Diseases, 2014, 8(7): e2993.
12.Xiangye Liu, Martine Cote, Paul E L Richard, Sarah I Bonnet. Impact of feeding system and infection status of the blood meal onIxodes ricinusfeeding. Ticks and Tick-Borne Diseases, 2014, 5(3): 323-328.
13.Xiangye Liu, Sarah I Bonnet. Hard tick factors implicated in pathogen transmission. PLoS Neglected Tropical Diseases, 2014, 8(1): e2566.
14.S Bonnet, J de la Fuente, P Nicollet,X Liu, N Madani, B Blanchard, C Maingourd, A Alongi, A Torina, de Mera IG Fernández, J Vicente, JC George, M Vayssier-Taussat, G Joncour. Prevalence of tick-borne pathogens in adultDermacentorspp. ticks from nine collection sites in France. Vector-Borne and Zoonotic Diseases, 2013, 13(4): 226-236.
15.Sarah Bonnet andXiangye Liu. Laboratory artificial infection of hard ticks: a tool for the analysis of tick-borne pathogen transmission. Acarologia, 2012, 52(4): 453-464.
16.刘相叶,孔德龙,付琳琳,潘伟,刘转转,郑葵阳,汤仁仙,一带一路背景下留学生人体寄生虫学教学改革的探索,医学教育研究与实践, 2018, 27(5): 870-872+882.
17.潘智华,郑辰,陈家旭,郑葵阳,刘相叶^*.田鼠巴贝虫感染致宿主血小板活化初步研究,中国媒介生物学及控制杂志,2018, 29(1): 24-27.
18.蒯蓉蓉,朱爱玲,董艳,郑辰,陈家旭,郑葵阳^*,刘相叶^*,青蒿琥酯与奎宁治疗巴贝虫病的疗效观察,中国病原生物学杂志, 2017, 12(9): 872-886.
19.李会琴,陈泽天,郑辰,闫红茹,付琳琳,郑葵阳,刘相叶^*,田鼠巴贝虫GAPDH蛋白特性和抗原表位的生物信息学分析,徐州医科大学学报, 2017, 37(9): 561-565.
20.刘相叶^*,郑辰,潘志华,寇艳波,郑葵阳^*,微小巴贝斯虫烯醇化酶蛋白主要特征与抗原表位的生物信息学分析,中国病原生物学杂志, 2017, 12(2): 136-138.
21.刘相叶,吴志强,刘转转,汤仁仙,颜超,郑葵阳,山东沂源硬蜱携带无形体的调查及进化分析,动物医学进展, 2015, 36(12): 103-107.
22.刘相叶,郑辰,李向阳,颜超,华慧,汤仁仙,郑葵阳^*,山东沂源羊体寄生长角血蜱携带病原调查研究，徐州医学院学报, 2015, 35(12): 837-840.






发表论文:
Human Babesiosis in China: a systematic review

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Glyceraldehyde-3-Phosphate Dehydrogenase of Babesia microti Is a Plasminogen- and Actin-Binding Protein

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JNK1/2 and EKR1/2 provides vital clues about tumor recurrence and survival in hepatocellular carcinoma patients

---

Molecular epidemiological survey of bacterial and parasitic pathogens in hard ticks from eastern China

---

IrSPI, a tick serine protease inhibitor involved in tick feeding and Bartonella henselae infection

---

Impact of feeding system and infection status of the blood meal on Ixodes ricinus feeding

---

Hard tick factors implicated in pathogen transmission

---

Laboratory artificial infection of hard ticks: a tool for the analysis of tick-borne pathogen transmission

---

Prevalence of tick-borne pathogens in adult Dermacentor spp. ticks from nine collection sites in France

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Reliability of molecular host-identificationmethods for ticks: an experimental in vitro study with Ixodes ricinus
教材专著:

科研项目:
CRBP1调控WIF1/Wnt/β-catenin通

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介导嗜吞噬细胞无形体传播的长角血蜱基因的筛选与研究

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长角血蜱传播嗜吞噬细胞无形体功能基因的筛选与研究

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介导嗜吞噬细胞无形体传播的蜱唾液腺基因的筛选与研究
获奖成果: