刘雪娇
硕士生导师

职称：副教授


学院：第一临床医学院
liuxuejiao0923@126.com







个人简介
刘雪娇，博士，副教授，硕士生导师，2013年作为优秀博士人才被徐州医科大学引进。现任中国医师协会脑胶质瘤专业委员会药物与生物治疗学组委员。获江苏省“六大人才高峰”高层次人才，江苏省“苏北发展”特聘专家，江苏省“青蓝工程”中青年学术带头人等人才称号。目前主要从事脑胶质瘤的发病机制与靶向治疗研究，近年来主持国家自然科学基金面上项目2项、国家自然科学基金青年基金1项、江苏省重点研发计划（社会发展）项目1项、江苏省自然科学基金青年基金项目1项、江苏省高校自然科学研究面上项目1项、中国博士后科学基金特别资助项目1项、中国博士后科学基金面上项目1项，累计获得科研经费550余万元。近5年，申请国家发明专利3项，已授权2项；发表SCI收录论文30余篇，其中以第一/通讯作者在Journal of Hematology & Oncology、Journal of Experimental &Clinical Cancer Research等杂志发表SCI收录论文20余篇。




发表论文:
High expression of Bruton’s tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma

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Smoothened is a poor prognosis factor and a potential therapeutic target in glioma

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CRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways

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CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells

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Plumbagin induces growth inhibition of human glioma cells by downregulating the expression and activity of FOXM1

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Hugl-1 inhibits glioma cell growth in intracranial model

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Novel reversible selective inhibitor of CRM1 for targeted therapy in ovarian cancer

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Novel reversible selective inhibitor of nuclear export shows that CRM1 is a target in colorectal cancer cells

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Plumbagin inhibits growth of glioma in vivo via suppression of FOXM1 expression

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Piperlongumine is a novel nuclear export inhibitor with potent anticancer activity
教材专著:

科研项目:
靶向UBA1调控内质网应激信号并诱导胶质母细胞瘤凋亡的作用及机制

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新型AKT/STAT3双靶点抑制剂诱导胶质母细胞瘤凋亡的作用与机制

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AKT与STAT3双靶向策略治疗恶性脑

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FoxR2蛋白的SUMO化修饰对脑胶质

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FoxR2蛋白的SUMO化修饰对脑胶质

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CRM1调控核质转运信号影响胶质瘤

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类泛素化修饰对FoxR2的调控及在
获奖成果: