吴登攀
硕士生导师

职称：副教授

学院：药学院
dengpanwu@xzmc.edu.cn







个人简介
吴登攀，男，2013年6月获得中山大学医学博士学位。同年6月进入徐州医科大学从事教学和科研工作。目前主要方向：神经系统疾病和肿瘤的发病机制及防治药物研究。现承担本科生《药理学》、研究生《药理学进展》及留学生《药理学》的理论与实验教学。近几年，先后主持和参与国家自然科学基金、江苏省高校自然基金、中国博士后科学基金等项目。以通讯作者或第一作者在Ageing Res Rev（IF：10.39）、Comput Struct Biotechnol J.（IF：6.018）、Aging (Albany NY)（IF：5.575）、Journal of Biophotonics（IF：4.328）和Int J Biol Sci.（IF：4.067）等杂志发表学术论文20余篇，参编专著3部。

成果奖励（近五年）
徐州市优秀论文三等奖。

科研项目（近五年）
1. 国家自然科学基金，**，经不同细胞缝隙连接通道传导的细胞内信号对光动力学治疗细胞毒性的影响研究，2015.01-2017.12，23万元，主持.
2. 中国博士后科学基金，2016M591927，Cx43在调控EMT介导的乳腺癌他莫昔芬耐药中的作用研究，2016.06-2018.05，5万元，主持.
3. 江苏省高校自然科学基金，14KJD310002，经不同GJ传导的细胞信号对PDT细胞毒性的影响研究，2014.08-2016.12，自筹，主持.
4. 徐州市科技计划项目，KC19018，新候选环状RNA circRNA-Trpc6对阿尔茨海默病β-淀粉样蛋白生成的影响及分子机制研究，2019.07-2020.06，4万元，主持.
5. 江苏省脑病生物信息重点实验课题，Jsbl201801，mmu_circ_000692在阿尔茨海默病β淀粉样蛋白形成中的作用研究，2018.09-2020.08，3万元，主持.
6. 国家自然科学基金，**，基于环状RNA探讨三七总皂苷调控快速老化模型小鼠SAMP8脑内β淀粉样蛋白形成的机制研究，2017.01-2020.12，36万元，参与（排名第三）.
7. 国家自然科学基金，**，三七总皂苷对快速老化痴呆模型小鼠SAMP8脑内氧化应激相关信号通路的影响研究，48万元，2015.01-2018.12，参与（排名第二）.
8. 国家自然科学基金，**，三七总皂苷对快速老化模型小鼠SAMP8大脑β淀粉样蛋白代谢通路影响的研究，26万元，2009.01-2012.12，参与（排名第二）。



论文情况（近五年）
1. Jin-Lan Huang, Min Su,Deng-Pan Wu*. Functional roles of circular RNAs in Alzheimer’s disease.Ageing Res Rev, 2020, 60:101058.
2. Jin-Lan Huang, Chao Yu, Min Su1, Si-Man Yang, Fan Zhang, Yuan-Yuan Chen, Jin-Yuan Liu, Yi-Fan Jiang, Zhen-Guo Zhong,Deng-Pan Wu*. Probucol, a “non-statin” cholesterol-lowering drug, ameliorates D-galactose induced cognitive deficits by alleviating oxidative stress via Keap1/Nrf2 signaling pathway in mice.Aging (Albany NY), 2019, 11(19): 8542-8555.
3. Jin-Lan Huang, Mei-Chun Qin, Yan Zhou, Zhe-Hao Xu, Si-man Yang, Fan Zhang, Jing Zhong, Ming-Kun Liang, Ben Chen, Wen-Yan Zhang,Deng-Pan Wu* and Zhen-Guo Zhong*. Comprehensive analysis of differentially expressed profiles of Alzheimer's disease associated circular RNAs in an Alzheimer's disease mouse model.Aging (Albany NY), 2018, 10(2): 253-265.
4. Jin-Lan Huang, Zhe-Hao Xu, Si-Man Yang, Chao Yu, Fan Zhang, Mei-Chun Qin, Yan Zhou, Zhen-Guo Zhong*,Deng-Pan Wu*. Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model.Comput Struct Biotechnol J., 2018, 16: 523-531.
5. Jin-Lan Huang, Xin Jing, Xin Tian, Mei-Chun Qin, Zhe-Hao Xu,Deng-Pan Wu*, and Zhen-Guo Zhong*. Neuroprotective Properties of Panax notoginseng Saponins via Preventing Oxidative Stress Injury in SAMP8 Mice.Evidence-Based Complementary and Alternative Medicine, 2017, 2017: **.
6. Jin-Lan Huang, Ying-Qin Feng, Li-Ru Bai, Mei-Chun Qin, Zhe-Hao Xu, Zhao-Rong Liu, Wen-Bing Chen,Deng-Pan Wu*and Zhen-Guo Zhong*.Fraction n-Butanol of Radix Notoginseng protects PC12 cells from Aβ-induced cytotoxicity and alleviates cognitive deficits in SAMP8 mice by attenuating oxidative stress and Aβ accumulation.Evidence-Based Complementary and Alternative Medicine, 2017, 2017: **.
7. Deng-Pan Wu, Li-Ru Bai, Yan-Fang Lv, Yan Zhou, Chun-Hui Ding, Si-Man Yang, Fan Zhang, Yuan-Yuan Wang, Jin-Lan Huang, Xiao-Xin Yin*. A Novel Role of Connexin 40-Formed Channels in the Enhanced Efficacy of Photodynamic Therapy.Frontiers in oncology, 2019, 9: 595.
8. Deng-Pan Wu, Li-Ru Bai, Yan-Fang Lv, Yan Zhou, Chun-Hui Ding, Si-Man Yang, Fan Zhang, Jin-Lan Huang*. A novel role of Cx43-composed GJIC in PDT phototoxicity: an implication of Cx43 for the enhancement of PDT efficacy.Int J Biol Sci., 2019, 15(3): 598-609.
9. Deng-Pan Wu, Chun-Hui Ding, Li-Ru Bai, Yan Zhou, Si-Man Yang, Fan Zhang, Jin-Lan Huang*. Decreased phototoxicity of photodynamic therapy by Cx32/Cx26-composed GJIC: a “Good Samaritan” effect.Lasers Surg Med., 2019, 51(3), 301-308.
10.Deng-Pan Wu, Tian-Yu Lin, Li-Ru Bai , Jin-Lan Huang, Yan Zhou, Nan Zhou, Sheng-Lei Zhong, Shan Gao and Xiao-Xing Yin*. Enhanced Phototoxicity of Photodynamic Treatment by Cx26-composed GJIC via ROS-, calcium- and lipid peroxide-mediated pathways.J. Biophotonics, 2017, 10(12):1586-1596.
11.Deng-Pan Wu, Tian-Yu Lin, Jin-Yan Lv, Wen-Ya Chen, Li-Ru Bai, Yan Zhou, Jin-Lan Huang*, Zhen-Guo Zhong*. Cestrum nocturnum Flower Extracts Attenuate Proliferation and Induce Apoptosis in Malignant Cells through Inducing DNA Damage and Inhibiting Topoisomerase II Activity.Evidence-Based Complementary and Alternative Medicine, 2017, 2017: **.
12.Deng-Pan Wu, Lixia Fan, Chenfang Xu, Zhen Liu, Yuan Zhang, Lucy Liu, Qin Wang*, Liang Tao. GJIC Enhances the phototoxicity of photofrin-mediated photodynamic treatment by the mechanisms related with ROS and Calcium pathways.Journal of Biophotonics, 2015, 8(9):764-774.



指导研究生情况(近五年)
1、2016级硕士研究生，吕艳芳；

2、2016级硕士研究生，禹超；
3、2018级硕士研究生，刘晓筱。

主讲课程（近五年）
本科生《药理学》、研究生《药理学进展》及留学生《药理学》的理论与实验教学。




发表论文:
Functional roles of circular RNAs in Alzheimer’s disease

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Probucol, a "Non-Statin" Cholesterol-Lowering Drug, Ameliorates D-galactose Induced Cognitive Deficits by Alleviating Oxidative Stress via Keap1/Nrf2 Signaling Pathway in Mice

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A Novel Role of Connexin 40-Formed Channels in the Enhanced Efficacy of Photodynamic Therapy

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A novel role of Cx43-composed GJIC in PDT phototoxicity: an implication of Cx43 for the enhancement of PDT efficacy

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Decreased Phototoxicity of Photodynamic Therapy by Cx32/Cx26-Composed GJIC: A “Good Samaritan” Effect

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Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model

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Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model

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Comprehensive analysis of differentially expressed profiles of Alzheimer“s disease associated circular RNAs in an Alzheimer”s disease mouse model

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Enhanced Phototoxicity of Photodynamic Treatment by Cx26-composed GJIC via ROS-, calcium- and lipid peroxide-mediated pathways

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Cestrum nocturnum Flower Extracts Attenuate Proliferation and Induce Apoptosis in Malignant Cells through Inducing DNA Damage and Inhibiting Topoisomerase II Activity
教材专著:

科研项目:
新候选环状RNA circRNA-Trpc6对阿尔茨海默病β-淀粉样蛋白生成的影响及分子机制研究

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基于环状RNA探讨三七总皂苷调控快速老化模型小鼠SAMP8脑内β淀粉 样蛋白形成的机制研究

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mmu_circ_000692在阿尔茨海默病β淀粉样蛋白形成中的作用研究

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Cx43在调控EMT介导的乳腺癌他莫昔芬耐药中的作用研究

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经不同细胞缝隙连接通道传导的细胞内信号对光动力学治 疗细胞毒性的影响研究

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经不同GJ传导的细胞信号对PDT细胞毒性的影响研究
获奖成果: