杨婷婷
学术型硕导

职称：讲师

学院：药学院
tty@xzhmu.edu.cn







个人简介
2017年12月毕业中国药科大学药物科学研究院，获理学博士学位；2018年入职徐州医科大学药学院工作。主要研究方向：1.糖尿病并发症（肝病和肾病）的发病机制及药物防治。2.临床合理用药以及疾病标志物的发现及机制。目前主持国家自然科学基金青年基金1项、江苏省高校自然科学基金面上项目1项、徐州医科大学优秀人才科研启动基金1项。近五年内以第一作者（共同第一）作者在《Metabolism》、《Cell Biol Toxicol》、《Food function》、《Toxicol Lett》、《Food Chem Toxicol》等杂志发表SCI收录论文11篇（单篇分数大于5分，4篇；最高分数7.321）。




发表论文:
SEW2871 attenuates ANIT-induced hepatotoxicity by protecting liver barrier function via sphingosine 1-phosphate receptor-1-mediated AMPK signaling pathway

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Amelioration of non-alcoholic fatty liver disease by sodium butyrate is linked to the modulation of intestinal tight junctions in db/db mice

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Sphingosine 1-phosphate receptor-1 specific agonist SEW2871 ameliorates ANIT-induced dysregulation of bile acid homeostasis in mice plasma and liver.

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Insulin exacerbated high glucose-induced epithelial-mesenchymal transition in prostatic epithelial cells BPH-1 and prostate cancer cells PC-3 via MEK/ERK signaling pathway.

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Simultaneous quantification of oestrogens and androgens in the serum of patients with benign prostatic hyperplasia by liquid chromatography-Tandem mass spectrometry

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Targeting mammalian serine/threonine-protein kinase 4 through Yes-associated protein/TEA domain transcription factor-mediated epithelial-mesenchymal transition ameliorates diabetic nephropathy orchestrated renal fibrosis.

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Quercetin improves nonalcoholic fatty liver by ameliorating inflammation, oxidative stress, and lipid metabolism in db/db mice

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YY1: A novel therapeutic target for diabetic nephropathy orchestrated renal fibrosis

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Bile acid homeostasis paradigm and its connotation with cholestatic liver diseases

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Early indications of ANIT-induced cholestatic liver injury: Alteration of hepatocyte polarization and bile acid homeostasis
教材专著:

科研项目:
基于肠道FXR/TGR5信号通路的肠道菌群调控2型糖尿病合并非酒精性脂肪性肝病肝细胞糖脂代谢的作用机制

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基于胆汁酸代谢轮廓的丁酸梭菌联合阿卡波糖缓解糖尿病肾病作用及其机制研究

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槲皮素预防治疗2型糖尿病合并非酒精性脂肪肝病的研究
获奖成果: