姓名：樊少华学位：博士
职称：教授、博士生导师
E-mail：fshfly@126.com

【教育背景】
学士学位：河北大学，生物学专业
硕士学位：福建农林大学，生物化学与分子生物学专业博士学位：上海交通大学，肿瘤学专业

【工作经历】
2004.8-至今：江苏师范大学，生命科学学院

【研究方向】
1.癌基因及相关基因功能
2.黄酮类抗肿瘤药物筛选

【工作业绩】
获得校三育人先进个人、校教学优胜奖、校优秀共产党员和校先进工作者等荣誉。在 Oncogene 和 Free Radical Biology & Medicine 等 SCI
期刊发表多篇论文，主持国家自然科学基金面上项目以及江苏省高校自然科学基金项目。

【承担的主要科研项目】
1．基于肝特异性敲除小鼠研究 LASS2 在肝细胞癌发生发展中的作用及机制，国家自然科学基金，面上项目（81672731），主持
2．LPCAT1 对乳腺癌细胞多药耐药性的作用及机制研究，江苏省高校自然科学基金
（12KJB320001），主持
3．慢病毒介导基因逆转乳腺癌多药耐药性的作用及机制研究，江苏师范大学 A 类博士科研项目（13XLR045），主持

【代表性论文】
1. Ning Sheng, Yanyan Wang, Ying Xie, Sihan Chen, Jun Lu, Zifeng Zhang, Mengqiu Li, Qun Shan,
Dongmei Wu, Guihong Zheng, Yuanlin Zheng, Shaohua Fan* (*corresponding author). High expression of
LASS2 is associated with unfavorable prognosis in patients with ovarian cancer. J Cell Physiol,
2019, 234(8):13001-13013.
2. Yanyan Wang, Ning Sheng, Ying Xie, Sihan Chen, Jun Lu, Zifeng Zhang, Qun Shan, Dongmei Wu,
Guihong Zheng, Mengqiu Li, Yuanlin Zheng, Shaohua Fan* (*corresponding author). J Cell Physiol,
2019, 234(8):13629-13638.
3. Shaohua Fan, et al. LASS2 enhances chemosensitivity of breast cancer by counteracting acidic
tumor microenvironment through inhibiting activity of V-ATPase proton
pump. Oncogene, 2013, 32(13):1682-1690.
4. Shaohua Fan, et al. Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic
steatosis and insulin resistance. Free Radic Biol Med, 2018, 120:330-341.
5. Shaohua Fan* (*corresponding author), et al. Low expression of ENC1 predicts a favorable
prognosis in patients with ovarian cancer. J Cell Biochem, 2019, 120(1):861-871.
6. Shaohua Fan, et al. High expression of glutamate-ammonia ligase is associated with unfavorable
prognosis in patients with ovarian cancer. J Cell Biochem, 2018, 119(7): 6008-6015.
7. Shaohua Fan, et al. AGPAT9 suppresses cell growth, invasion and metastasis by counteracting
acidic tumor microenvironment through KLF4/LASS2/V-ATPase signaling pathway in breast cancer.
Oncotarget, 2015, 6(21):18406-18417.

8. Shaohua Fan, et al. CERS2 suppresses tumor cell invasion and is associated with decreased
V-ATPase and MMP-2/MMP-9 activities in breast cancer. J Cell Biochem, 2015, 116(4):502-513.
9. Shaohua Fan, et al. Luteoloside suppresses proliferation and metastasis of hepatocellular
carcinoma cells by inhibition of NLRP3 inflammasome. PLoS One, 2014, 9(2):e89961.
10. Shaohua Fan, et al. Purple sweet potato color attenuates D-galactose-induced renal injury in
mice by inhibiting the expression of NF-κB-dependent inflammatory genes. J Med Plants Res, 2012,
6(21):3694-3704.
11. Shaohua Fan, et al. Troxerutin protects the mouse kidney from D-galactose-caused injury through
anti-inflammation and anti-oxidation. Int Immunopharmacol, 2009, 9(1):91-96.
12. Shaohua Fan (Co-first author), et al. GLUL promotes cell proliferation in breast cancer. J Cell
Biochem, 2017, 118(8):2018-2025.
13. Shaohua Fan (Co-first author), et al. Gas6/Axl axis contributes to chemoresistance and
metastasis in breast cancer through Akt/GSK-3β/β-catenin signaling. Theranostics, 2016,
6(8):1205-1219.
14. Shao-hua Fan (Co-first author), et al. Troxerutin protects the mouse liver against oxidative
stress-mediated injury induced by D-galactose. J Agric Food Chem, 2009, 57(17):7731-7736.