姓名：李少钦 学位：博士学位
职称：特聘教授、研究生导师
E-mail: lee_shao@hotmail.com

【教育背景】
学士学位：厦门大学，理学（微生物学）学士
硕士学位：第一军医大学（现为南方医科大学），医学（免疫学）硕士博士学位：新西兰奥克兰大学哲学，（生物科学）博士

【工作经历】
2018-至今：江苏师范大学全职特聘教授
2014-至今: 山西大学特聘教授、博导
2011-2013：香港中文大学研究助理教授、博导
2003-2010：新加坡国立大学首席研究员、博导
1997-2002：香港中文大学博士后、副研究员

1991-1992：澳大利亚昆士兰大学研究员
1989-1991：澳大利亚悉尼大学访问学者
1986-1989：第一军医大学（现为南方医科大学）助教

【研究方向】
1.糖尿病人肿瘤易感性增高的生物学原理和分子机制
2.细胞中心体扩增的信号通路
3.天然化合物诱导的肿瘤细胞凋亡和分子途径
4.技术平台是功能蛋白质组学

【工作业绩】
招收培养博士生和硕士生，全部发表 SCI 文章，顺利毕业并进一步深造或找到好工作。获批国内外专利四项。
主要学术贡献：
1.把人类血色病的基因定位在第 6 号染色体的 D6S105 位点附近，为最终克隆改疾病基因提供坐标方向；
2.发现 2 型糖尿病人发病有遗传期望的想象的证据；
3.发现糖尿病父亲对子女糖尿病发病的影响规律；
4.发现 2 型糖尿病人体内细胞的中心体扩增水平升高，并阐明分子机制，为解释糖尿病人肿瘤易感性增高的临床想象提供一个独特的假说。

【承担的主要科研项目】
1.糖尿病人肿瘤易感性增高的生物学原理和分子机制。江苏师范大学。900000 RMB。
2018-2020
2.肿瘤细胞中心体扩增和凋亡的关系及其分子机制的研究。山西大学。1000000 RMB。
2014-2016
3.Characterizing the resveratrol-evoked, Bax and p53independent apoptosis signaling cascades: in
relevance to the therapeutic development of resveratrol in treating drug-resistant cancers.
National Medical Research Council of Singapore, 201,550 SGD, 2008-2011
4.Proteomic delineation of p53 signaling pathways. National Medical Research Council of Singapore
190,000 SGD, 2009-2011
5.Glucose-evoked cell death and underlying molecular mechanisms: in relevance to the development of
diabetic nephropathy. National Medical Research Council

of Singapore 190,000 SGD, 2009-2011
6.Establishment of a catalogue of Chinese-specific genetic markers for obesity, diabetes and
diabetic kidney disease. Hong Kong Innovation Technology Fund, 4,473,000 HKD, 2000-2003
7.Screening for mutation/polymorphisms in obesity-related genes, melanocortin-4 receptor,
uncoupling protein 2 and 3 and tumor necrosis factor-a, in Chinese patients with early-onset type 2
diabetes and a positive family history. Chinese University of Hong Kong, 110,000 HKD, 2000-2001
8.Role of hyperglycemia and oxidative stress on gene expression implicated in cancer pathways in
type 2diabetes. Sanofi, 832,600 HKD, 20120-2013
9.Genome-wide search for diabetes-associated genes in Chinese patients with type 2 diabetes
characterized by insulin deficient or non-insulin resistance in Hong Kong. Hong Kong Research Gant
Council. 580,000 HKD, 1999-2001 10.Establishment of a catalogue of Chinese-specific genetic markers
for obesity, diabetes and diabetic kidney disease. Hong Kong Industrial Fund. 500000 HKD, 2000-2003
11.Mapping genes for young onset diabetes obesity and diabetic nephropathy. Chinese University of
Hong Kong. 500000 HKD. 1999-2001.

代表性论文：（按照由近及远的顺序填写）
1.Wang P, Lee S. Diabetes increases the expression of MDM2. J Diabetes Res. In press, 2018
2.Wang P, Lu YC, Wang J, Wang L, Yu H, Li YF, Kong A, Chan J, Lee S*. Type 2 Diabetes Promotes Cell
Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ. Cell Physiol
Biochem. 47:356-367,2018 3.Huo J, Dong A, Niu X, Dong A, Lee S*, Ma C, Wang L. Effects of cadmium
on oxidative stress activities in plasma of freshwater turtle Chinemys reevesii. Environ Sci Pollut
Res Int. 25:8027-8034, 2018
4.Yang Y, Zhang Y, Wang L, Lee S*. Levistolide A Induces Apoptosis via
ROS-Mediated ER Stress Pathway in Colon Cancer Cells. Cell Physiol Biochem. 42:929-938, 2017
5. B, Li D, Jing W, Fan J, Dahms HU, Lee SC*, Wang L. Biogenic selenium and its hepatoprotective
activity. Sci Rep. 15;7(1):15627, 2017
6.ang L, Zhang Z, Jing W, Hwang JS, Lee SC, Wang L. Identification of a novel

toll gene (Shtoll3) from the freshwater crab Sinopotamon henanense and its expression pattern
changes in response to cadmium followed by Aeromonas hydrophila infection. Fish Shellfish Immunol.
71:177-190, 2017
7.Huo J, Dong A, Wang Y, Lee S*, Ma C, Wang L. Cadmium induces histopathological injuries and
ultrastructural changes in the liver of freshwater turtle (Chinemys reevesii). Chemosphere.
186:459-465, 2017
8.Huo J, Dong A, Yan J, Wang L, Ma C, Lee S*. Cadmium toxicokinetics in the freshwater turtle,
Chinemys reevesii. Chemosphere. 182:392-398, 2017
9.Liu N, Yang HL, Wang P, Lu YC, Yang YJ, Wang L, Lee SC*. Functional proteomic analysis revels
that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through
endoplasmic reticulum stress pathway. J Ethnopharmacol. 189:210-7, 2016
10. Wang P, Yang HL, Yang YJ, Wang L, Lee SC*. Overcome Cancer Cell Drug Resistance Using Natural
Products. Evid Based Complement Alternat Med. 2015:767136, 2015
11.Lee SC*, Chan JC. Evidence for DNA damage as a biological link between diabetes and cancer. Chin
Med J (Engl). 128:1543-8, 2015
12.Wang Y, Ng MC, Lee SC, So WY, Tong PC, Cockram CS, Critchley JA, Chan JC. Phenotypic
heterogeneity and associations of two aldose reductase gene polymorphisms with nephropathy and
retinopathy in type 2 diabetes. Diabetes Care. 26:2410-2415, 2013
13.Lee SC*, Chan J, Proteomic identification of TCP-1 gamma as p53 responsive protein. Cancer
Genomics and Proteomics. 9:101-108, 2012
14.Chan J, Benny Tan, Lee SC*. Scutellarin sensitizes drug-evoked colon cancer cell apoptosis
through enhanced caspase-6 activation. Anticancer Res.
29:3043-3047, 2009
15.ee SC*, Chan J, Pervaiz S. Spontaneous and 5-fluorouracil-evoked centrosome amplification lowers
the threshold to resveratrol-induced apoptosis in colon cancer cells. Cancer Lett. 288:36-41, 2009
16.Chan J, Phoo R, Clement M, Pervaiz S, Lee SC*. Resveratrol displays converse dose-related
effects on 5-fluorouracil-evoked colon cancer cell apoptosis: the roles of caspase-6 and p53.
Cancer Bio & Therapy. 7:1-8, 2008
17.Lee SC*, Sim N, Clement M, Yadav S, Pervaiz S. Dominant negative Rac1N17 attenuates human
melanoma M14 cell apoptosis sensitivity by upregulation of heat

shock protein 27: a functional proteomic study. Proteomics. 7:4112-4122, 2007 18.Lee SC*, Pervaiz
S. Apoptosis in the pathogenesis of diabetes mellitus and its microvascular complications. Int J
Biochem Cell Biol. 39:497-504, 2007 19.Lee SC, Chan J, Clement M, Pervaiz S. Functional proteomic
analysis of resveratrol-evoked colon cancer cell apoptosis: caspase-6 cleavage of lamin A is a
major signalling loop. Proteomics. 6:2386-94, 2006
20.Ko GT, Lee SC, Pu YB, Ng MC, So WY, Thomas N, Chan WB, Cockram CS, Chan JC. Tumour necrosis
factor-alpha promoter gene polymorphism at - 308 (genotype AA) in Chinese subjects with Type 2
diabetes. Diabet Med. 20:167-168, 2003 21.Lee SC*, Cooper GJS. Amylin evokes protein p20
phosphorylation and insulin resistance in rat skeletal muscle extensor digitorum longus. Sci China
45:159-165, 2002.
22. Lee SC*, Pu YB, Thomas NG, Critchley JAJH, Thomlinson B, Cockram CS and Chan JCN. Tumor
necrosis factor-? gene G-308A polymorphism in the metabolic syndrom. Metab 49:1021-1024, 2000
23. Lee SC*, Wang Y, Ko GTC, Critchley JAJH, Cockram, CS and Chan JCN. Risks factors for cataract
in Chinese patients with type 2 diabetes: Evidence for the influence of the aldose reductase gene.
Clin Genet 59:356-359, 2001
24.Ng MC, Lee SC, Ko GT, Li JK, So WY, Hashim Y, Barnett AH, Mackay IR, Critchley JA, Cockram CS,
Chan JC. Familial early-onset type 2 diabetes in Chinese patients: obesity and genetics have more
significant roles than autoimmunity. Diabetes Care 24:663-671, 2001:8：
25.Lee SC*, Ko GTC, Li JKY, Chow CC, Yeung VTF, Critchley JAJH, Cockram CS, Chan JCN. Factors
predicting the age at diagnosis of type 2 diabetes in Hong Kong Chinese. Diabetes Care 24:646-649,
2001
26. Chan JCN, Ng M, Critchley JAJH, Lee SC, Cockram CS. Diabetes mellitus-a special medical
challenge from a Chinese perspective. Diabetes Res Clin Pract 54 (Suppl 1):19-27, 2001
27. Lee SC*, Hashim, Y. Li JKY, Ko GTC, Critchley JAJH, Cockram CS and Chan JCN. The islet amyloid
polypeptide (amylin) gene S20G mutation in Chinese subjects: Evidence for associations with Type 2
diabetes and cholesterol levels Clin Endocr 54:541-546, 2001
28.Lee SC*, Pu YB, Chow CC, Yeung VTF, Ko GTC, So WY, Li JKY, Chan WB, Ma RCW,
Critchley JAJH, Cockram CS and Chan JCN. Diabetes in Hong Kong Chinese: Familial

clustering and parental effects. Diabetes Care 23:1365-1368, 2000 29.Jazwinska EC, Pyper WR, Burt
MJ, Francis JC, Goldwurm S, Webb SI, Lee SC, Halliday JW and Powell LW. Haplotype analysis in
Australian hemochromatosis patients: Evidence for a predominant ancestral haplotype exclusively
associated with hemochromatosis. Am J Hum Genetic 55:128-125, 1995
30.Jazwinska EC, Lee SC, Webb SI, Halliday JW and Powell LW. Mapping of hemochromatosis gene to
close to D6S105 and HLA-A by linkage analysis. Am J Hum Genet 53:347-352, 1993