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江苏师范大学生命科学学院导师教师师资介绍简介-张子峰
/2021-03-28
姓名:张子峰 学位:博士学位
职称:校聘教授、博士生导师
E-Mail:zhangzifengsuper@jsnu.edu.cn
【教育背景】
学士学位:徐州师范大学,生物学教育硕士学位:徐州师范大学,细胞遗传学
博士学位:中国矿业大学,环境生物学/环境毒理学
【工作经历】
2011 年 8 月至今:江苏师范大学,副教授,校聘教授
2003 年 7 月-2011 年 7 月:徐州师范大学,生命科学学院,助教、讲师
【研究方向】
1. 肝脏糖脂代谢障碍的病理机制及干预研究
2. 持续性有机污染物作为糖尿病风险因子的机制及干预研究
【工作业绩】
主持在研国家自然基金面上项目及校博士学位教师科研支持项目(A 类)各 1 项,主持完成省自然科学基金面上项目、省教育厅自然科学基金面上项目等基金,参与国家自然科学基金 3
项,获江苏省科技进步奖三等奖 1 项(4/7)。在 SCI 期刊上发表相关研究论文 30 篇,以第一及通讯作者在 SCI 1 区及 2 区期刊上发表论文 7 篇、3 区论文
4篇。研究工作被《Nature Reviews Endocrinology》正面引用,被毒理学权威杂志
《Archives of toxicology》综述文章以一个段落的篇幅介绍,被《Canadian Journal of Gastroenterology and
Hepatology》(IF=2.147,3 区)聘为客座主编(lead guest editor),被《 Biomedicine &
Pharmacotherapy》等学术期刊邀请为审稿人。承担本科生及研究生细胞生物学等专业基础课程,指导本科生多次获得校级及院级的优秀论文嘉奖,获得国家级/省级重点大学生创新项目。
【承担的主要科研项目】
1.蛋白质内稳态失衡介导的内皮素受体 A 上调致肝脏胰岛素抵抗的机制及曲克芦丁干预研究:国家自然基金面上项目(81570531),2016.1-2019.12,在研、主持
2.热休克因子 1 下调促进空腹高血糖的分子机制及花青素干预研究:校博士学位教师科研支持项目(A 类)(15XLR005),2016.1-2017.12,在研、主持
3.HDAC5 介导肝脏损伤的分子机制及花青素干预研究:省自然基金面上项目
(BK20131127),2013.7-2016.6,结题、主持
4.紫甘薯花青素保护 D-Galactosamine/Lipopolysaccharide
诱导小鼠凋亡性肝损伤的分子机制:省高校自然科学基金面上项目(09KJB180003),2009.9-2010.12,结题、主持
5.紫甘薯花青素对脂多糖(LPS)诱导的小鼠肝脏炎症保护作用的分子机制研究:校自然科学基金重点项目(07XLA09),2008.1-2009.12,结题,主持
6.环境雌激素双酚 A 的生殖毒性研究:校自然科学基金一般项目(04XLB17),
2005.1-2006.12,结题、主持
【代表性论文】
1.Xin Wang?, Zi-Feng Zhang *,?(co-corresponding author), Gui-Hong Zheng, Ai-Min Wang, Chun-Hui Sun,
Su-Ping Qin, Juan Zhuang, Jun Lu, Dai-Fu Ma and Yuan-Lin
Zheng *, The Inhibitory Effects of Purple Sweet Potato Color on Hepatic Inflammation Is Associated
with Restoration of NAD+ Levels and Attenuation of NLRP3 Inflammasome Activation in
High-Fat-Diet-Treated Mice, Molecules 2017, 22(8), 1315; doi:10.3390/molecules22081315. (SCI 3 区
IF= 2.861)
2.Xin Wang, Zi-feng Zhang# (Co-first author), Gui-Hong Zheng, Ai-Min Wang, Chun-Hui Sun, Su-Ping
Qin, Juan Zhuang, Jun Lu, Dai-Fu Ma and Yuan-Lin Zheng
*,Attenuation of hepatic steatosis by purple sweet potato color is associated with blocking
Src/ERK/C/EBPβ signalling in high-fat-diet-treated mice,Applied Physiology, Nutrition, and
Metabolism , 2017, in press , https://doi.org/10.1139/apnm-2016-0635.(SCI 3 区 IF=
2.023)
3.Zi-feng Zhang, Xin Wang, Gui-Hong Zheng, Qun Shan, Jun Lu, Shao-hua Fan, Chun-Hui Sun, Dong-mei
Wu, Cheng Zhang, Wei-Tong Su, Jun-Wen Sui, and Yuan-lin Zheng*, Troxerutin Attenuates
Enhancement of Hepatic Gluconeogenesis by Inhibiting NOD Activation-Mediated Inflammation in
High-Fat Diet-Treated Mice, International journal of molecular sciences, 2017, 18(1),
31; doi:10.3390/ijms18010031.(SCI 3 区 IF= 3.257)
4.Zi-feng Zhang, Qun Shan, Juan Zhuang, Yan-Qiu Zhang*, XinWang, Shao-hua Fan, Jun Lu, Dong-mei
Wu, Bin Hu, and Yuan-lin Zheng*, Troxerutin inhibits 2,2',4,4'-tetrabromodiphenyl ether
(BDE-47)-induced hepatocyte apoptosis by restoring proteasome function, Toxicology Letters, 2015,
233(3):246-257.(SCI 2 区 IF=3.522)
5.Zi-feng Zhang, Yan-Qiu Zhang, Shao-hua Fan, Juan Zhuang, Yuan-lin Zheng*, Jun Lu, Dong-mei Wu,
Qun Shan, and Bin Hu, Troxerutin protects against 2,2',4,4'-tetrabromodiphenyl ether
(BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NAD(+)-depletion,
Journal of hazardous materials, 2015, 283:98-109. (SCI 1 区 Top IF=4.834)
6.Zi-feng Zhang, Shao-hua Fan, Yuan-lin Zheng*, Jun Lu, Wu DM, Qun Shan, and Bin Hu, Troxerutin
improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of
lipin 1 signaling in high-fat diet-treated mice, Biochemical pharmacology, 2014, 91(1):74-86.
(SCI 2 区 Top IF=5.091)
7.Zi-feng Zhang, Jun Lu, Yuan-lin Zheng*, Dong-mei Wu, Bin Hu, Qun Shan, Wei Cheng, Meng-qiu Li,
and Yuan-yuan Sun, Purple sweet potato color attenuates hepatic insulin resistance via blocking
oxidative stress and endoplasmic
reticulum stress in high-fat-diet-treated mice, Journal of nutritional biochemistry, 2013,
24(6):1008-1018.(SCI 2 区 IF=4.592)
8.Zi-feng Zhang, Jun Lu, Yuan-lin Zheng*, Bin Hu, Shao-hua Fan, Dong-mei Wu, Zi-hui Zheng, Qun
Shan, and Chan-min Liu, Purple sweet potato color protects mouse liver against d-galactose-induced
apoptosis via inhibiting caspase-3 activation and enhancing PI3K/Akt pathway, Food and Chemical
Toxicology, 2010, 48 (8-9):2500 -2507. (SCI 2 区 IF=2.6)
9.Zi-feng Zhang, Shao-hua Fan, Yuan-lin Zheng*, Jun Lu, Dong-mei Wu, Qun Shan, and Bin Hu,
Troxerutin protects the mouse liver against oxidative stress-mediated injury induced by
D-galactose, Journal of Agricultural and Food Chemistry, 2009, 57(17):7731-7736. (SCI 1 区 Top
IF=2.806)
10.Zi-feng Zhang, Shao-hua Fan, Yuan-lin Zheng*, Jun Lu, Dong-mei Wu, Qun Shan, and Bin Hu.
Purple sweet potato color attenuates oxidative stress and inflammatory response induced by
d-galactose in mouse liver, Food and Chemical Toxicology, 2009, 47(2):496-501. (SCI 2 区 IF=2.114)
11.Shao-hua Fan#, Zi-feng Zhang# (Co-first authors), Yuan-lin Zheng*, Jun Lu, Dong-mei Wu, Qun
Shan, Bin Hu, and Yan-yan Wang, Troxerutin protects the mouse kidney from D-galactose-caused
injury through anti-inflammation and anti-oxidation, International Immunopharmacology, 2009,
9(1): 91-96.(SCI 3区 IF=2.214)
12.张子峰,樊少华,陆军,吴冬梅,单群,胡斌,李飞,郑元林*,小鼠 ERβ 基因片段的克隆及其在胚胎发育中的表达,遗传,2008(3):347-351。
13.张子峰,樊少华,陆军,吴冬梅,单群,胡斌,李飞,郑元林*,整体原位杂交检测 ERα基因在小鼠胚胎发育中的表达,动物学杂志,2008,43(3):39-44。
14.张子峰, 小鼠卵母细胞减数分裂染色体的简易制备, 生物学通报, 2004, 10:55。
15.朱必才#*,张子峰# (并列第一作者),张 永,高俊芳,董玉玮,侯进慧,棕色田鼠 X0 雌体的减数分裂,动物学报,2004,50(1):68-74。