姓名：赵立明
学位学历：博士研究生
职称：教授
职务：教研室主任
学科专业：药物化学
E-mail: lmzhao@jsnu.edu.cn

【个人简历】
1. 教育背景和工作简历
2008年7月至今，江苏师范大学化院制药教研室
2013年10月-2014年11月，在美国Purdue University药学院药物化学与分子药理学系Mark Cushman教授（JMC副主编）课题组从事研究工作
2008年6月毕业于上海交通大学药学院，获药物化学专业博士学位
1998年6月毕业于延边大学药学院，获药学专业学士学位；同年7月留校任教，任职于药物化学教研室
2. 工作成绩及学术成果
参加工作以来，一直从事药物化学的教学和科研工作，主讲《药物化学》、《Organic Reactions for Drug Synthesis》等课程；近五年来已在Org. Lett., Chem. Commun., J. Org. Chem., Adv. Synth. Catal., Bioorg. Med. Chem., Eur. J. Med. Chem., Bioorg. Med. Chem. Lett., Curr. Med. Chem., Future Med. Chem., Org. Biomol. Chem.等本领域主流刊物上发表了系列研究成果；获中国发明专利授权1项；指导研究生20名，已毕业13名；指导江苏省大学生创新创业训练计划项目3项。

【研究领域和兴趣】
1. 小分子抗肿瘤化合物设计合成及活性研究
2. 形成碳碳键的新反应研究及其在合成生物活性分子中的应用

【代表性论文】
1. Fang, Qing-Yun; Jin, Hai-Shan; Wang, Ru-Bing;* Zhao, Li-Ming.* DABCO-mediated [3+3] cycloaddition of azomethine imines with in situ generated nitrile oxides from hydroximoyl chlorides. Chem. Commun. 2019, 55, 10587-10590.
2. Li, De-Feng; Gu, Yan; Zhang, Jing-Ru; Liu, Kun; Zhao, Li-Ming.* Diastereoselective Construction of Spiro-furo[3,2-c]benzopyranoxindoles through a Cu(OTf)2/AcOH Cooperative Promoted Bicyclization Reaction. J. Org. Chem. 2019, 84, 879-887.
3. Zhang, Jing-Ru; Jin, Hai-Shan; Wang, Ru-Bing;* Zhao, Li-Ming.* Synthesis of 2,4-Diaryl-1,3-benzoxazines via FeCl3-Catalyzed Annulation of ortho-Hydroxyphenyl-Substituted para-Quinone Methides with Imidates. Adv. Synth. Catal.2019, 361, 4811-4816.
4. Zhang, Jie-Huan; Mottamal Madhusoodanan; Jin, Hai-Shan; Guo, Shanchun; Gu, Yan; Wang, Guangdi;* Zhao, Li-Ming.* Design, Synthesis, and Evaluation of Belinostat Analogs as Histone Deacetylase Inhibitors. Future Med. Chem.2019, 11, 2765-2778.
5. Zhao, Li-Ming;* Zhang, Jie-Huan. Histone Deacetylase Inhibitors in Tumor Immunotherapy. Curr. Med. Chem.2019, 26, 2990-3008.
6. Zhao, Li-Ming;* Liu, Kun; Li, De-Feng. One-Pot Synthesis of aza-Morita-Baylis-Hillman Adducts via Zinc-Mediated Allylation of 4-Bromocrotonates and Imines. J. Org. Chem.2019, 84, 15429-15436.
7. Li, De-Feng; Liu, Kun; Jiang, Yi-Xuan; Gu, Yan; Zhang, Jing-Ru; Zhao, Li-Ming.* Access to 3-Prenylated Oxindoles by α-Regioselective Prenylation: Application to the Synthesis of (±)-Debromoflustramine E. Org. Lett.2018, 20, 1122-1125.
8. Zhao, Li-Ming;* Gao, Hua-Shuai; Li, De-Feng; Dong, Jing; Sang, Lan-Lin; Ji, Jie. Zinc-mediated α-regioselective Barbier-type cinnamylation reactions of aldehydes, ketones and esters. Org. Biomol. Chem.2017, 15, 4359-4366.
9. Zhao, Li-Ming;* Zhang, Ai-Li; Zhang, Jie-Huan; Gao, Hua-Shuai; Zhou, Wei. Zinc-Mediated C-3 α-Prenylation of Isatins with Prenyl Bromide: Access to 3-Prenyl-3-hydroxy-2-oxindoles and Its Application. J. Org. Chem. 2016, 81, 5487-5494.
10. Zhao, Li-Ming; Jin, Hai-Shan; Liu, Jinzhong; Skaar, Todd C.; Ipe, Joseph, Lv, Wei, Flockhart, David A.; Cushman, Mark.* A new Suzuki synthesis of triphenylethylenes that inhibit aromatase and bind to estrogen receptors α and β. Bioorg. Med. Chem. 2016, 24, 5400-5409.
11. Zhao, Li-Ming;* Cao, Feng-Xia; Zhang, Jie-Huan; Szwayab, Jeffrey; Wang, Guangdi.* One-pot synthesis of 1,4-dihydroxy-2-((E)-1-hydroxy-4-phenylbut-3-enyl)anthracene-9,10-diones as novel shikonin analogs and evaluation of their antiproliferative activities. Bioorg. Med. Chem. Lett. 2016, 26, 2691-2694.
12. Zhao, Li-Ming;* Zhang, Ai-Li; Gao, Hua-Shuai; Zhang, Jie-Huan. Synthesis of Furo[3,2-c]benzopyrans via an Intramolecular [4 + 2] Cycloaddition Reaction of o-Quinonemethides. J. Org. Chem.2015, 80, 10353-10358.
13. Zhao, Li-Ming;* Ma, Feng-Yan; Jin, Hai-Shan; Zheng, Shilong; Zhong, Qiu; Wang, Guangdi.* Design and synthesis of novel hydroxyanthraquinone nitrogen mustard derivatives as potential anticancer agents via a bioisostere approach. Eur. J. Med. Chem.2015, 102, 303-309.
14. Zhao, Li-Ming;* Zhang, Shu-Qing; Dou, Fei; Sun, Rui. Zinc-Mediated Highly α-Regioselective 1,4-Addition of Chalcones with Prenyl Bromide in THF. Org. Lett. 2013, 15, 5154-5157.
15. Zhao, Li-Ming;* Zhang, Shu-Qing; Jin, Hai-Shan; Wan, Li-Jing; Dou, Fei. Zinc-Mediated Highly α-Regioselective Prenylation of Imines with Prenyl Bromide. Org. Lett.2012, 14, 886-889.
16. Zhao, Li-Ming;* Zhang, Li-Ming; Liu, Jin-Juan; Wan, Li-Jing; Chen, Yong-Qiang; Zhang, Shu-Qing; Yan, Zhi-Wei; Jiang Ji-Hong. Synthesis and antitumor activity of conjugates of 5-Fluorouracil and emodin. Eur. J. Med. Chem.2012, 47, 255-260.
17. Zhao, Li-Ming;* Jin, Hai-Shan; Wan, Li-Jing; Zhang, Li-Ming. General and Highly α-Regioselective Zinc-Mediated Prenylation of Aldehydes and Ketones. J. Org. Chem. 2011, 76, 1831-1837.

【发明专利】
1. 赵立明，蒋继宏，金海善，刘金娟，张黎明。抗肿瘤活性的大黄素和5-氟尿嘧啶拼合物及其制备方法；发明专利；授权时间：2013.06；授权国别：中国；专利号：ZL7.2
2. 赵立明，马凤燕。具有抗肿瘤活性的羟基蒽醌氮芥衍生物及其制备方法；发明专利；申请号：9.7
3. Cushman, Mark; Lv, Wei; Zhao, Li-Ming. Preparation of triphenylethylene compounds and uses thereof in cancer treatment. U.S. Pat. Appl. Publ. (2017), US A1 **.
4. 赵立明，张皆欢，金海善。具有组蛋白去乙酰化酶抑制活性的贝利司他的结构类似物及其应用；发明专利；申请号：5.3

【会议报告】
1. 口头报告：“异戊烯化反应中的区域选择性研究及其在天然产物合成中的应用”中国化学会第31届学术年会，杭州，2018. 05.05-08
2. 口头报告：“Zinc-Mediated α-Regioselective Prenylation Reactions”第十三届中美华人化学教授会议，南通，2017. 06.17-20
3. 口头报告：“High Regiocontrol in the Zinc-Mediated Allylation of Aldehydes and Ketones”第九届江淮有机化学论坛，常州，2011. 10.14-16

【毕业研究生去向】
1. 张黎明上海合全药物研发有限公司
2. 万里晶苏州康润医药有限公司
3. 张舒情上海睿智化学研究有限公司
4. 燕志卫承德医学院中药研究所（工作）
5. 马凤燕江阴迈康升华医药科技有限公司
6. 窦飞江苏恩华药业股份有限公司
7. 曹凤霞徐州市镇北铁矿有限公司
8. 孙瑞中国药科大学制药有限公司
9. 张爱莉江苏神华药业有限公司
10. 徐双双上海桑迪亚医药技术有限公司
11. 张皆欢都创（上海）新药研发有限公司
12. 高华帅中国矿业大学（博士生）
13.李德峰江苏豪森药业集团有限公司