主要研究方向为化学生物学。作为负责人先后主持中国国家自然科学基金，中国博士后基金、江苏省自然科学基金、江苏大学高级人才启动基金等，已在Nucleic Acids Res., Chem. Comm., J. Org. Chem., Org. Biomol. Chem., Bioorg. Med. Chem., New J. Chem., Dyes and Pigments等国际知名学术期刊上共发表SCI收录学术论文20余篇；单篇影响因子最高为11.5，单篇他引最高为182次。授权中国发明专利1项。同时担任国际国内重要刊物的论文评审专家，包括Sensor Actuat B-Chem；Sci Rep-UK、Eur J Med Chem等国际化学领域主流期刊。荣获江苏大学“优秀教师”荣誉称号。
【联系方式】
E-mail: wmq3415@163.com
Tel: **
【教育经历】
2005.09-2009.06 淮阴师范学院，环境科学专业，获学士学位
2009.09-2014.07 四川大学，有机化学专业，获博士学位
【工作经历】
2012.06-2013.01 冈山大学（Okayama University），日本，国际交流合作
2016.12-2019.06 江苏大学博士后
2014.07-至今 江苏大学 制药工程系
【科研项目】（项目负责人）
1、 基于深红/近红外两亲性BODIPY荧光纳米探针的设计、自组装及G-四链体DNA识别应用，国家自然科学青年基金，25万，主持。
2、 端粒G4-DNA为靶点的喹啉类衍生物结构修饰及机理研究，中国博士后科学基金，5万，主持已结题
3、 端粒DNA识别分子的核酸调控及相关信号转导干预研究，江苏高等学校自然科学研究面上项目，5万，主持已结题
4、 基于深红/近红外两亲性BODIPY荧光分子自组装：分子设计、G-四链体DNA识别与生物应用，江苏省青年科学基金，20万，主持
5、 G-四链体DNA荧光探针分子的设计合成及其抗肿瘤活性研究，江苏大学高级人才启动，主持，5万，主持已结题
6、 一种具有电荷转移特性的荧光探针及其制备方法和用途，企业合作课题，3万，主持
【研究方向】
1、 核酸药物化学和核酸化学生物学
2、 超分子自组装荧光纳米探针
3、 新型光功能有机分子的构建及其应用
招生方向：
1、药物化学
2、生物与医药
【代表性论著】（第一作者和通讯作者论文）
[1] Wang, Ming-Qi*, Gao, Juan-Juan, Yu, Quan-Qi, Liu, Hong-Bei. An amphiphilic BODIPY-based selective probe for parallel G4 DNA targetingviadisaggregation-induced emission. New Journal of Chemistry, 2020, 44: 13557-13564.
[2] Yu, Quan-Qi, Wang Ming-Qi*. Carbazole-based fluorescent probes for G-quadruplex DNA targeting with superior selectivity and low cytotoxicity. Bioorganic & Medicinal Chemistry, 2020, 28, 115641.
[3] Zeng Xin-Yue, Zhu, Qing-Zhong; Yu, Quan-Qi, Wang Ming-Qi*. Conjugating a groove binder analogue to a styryl-quinolinium scaffold for the light-up detection of duplex and G-Quadruplex DNA with different binding modes. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 228, 117705.
[4] Wang, Ming-Qi*, Liao, Yi-Fan, Zhang, Shu-Hui, Yu, Quan-Qi, Huang, Jin-Qiu. Synthesis, G-Quadruplex DNA binding and cytotoxic properties of naphthalimide substituted styryl dyes. Bioorganic & Medicinal Chemistry, 2020, 28, 115325.
[5] Wang Ming-Qi*, Zhang Yuan, Zeng Xin-Yue, Yang Huan, Yang Chen, Fu Ruo-Ying, Li Hong-Ju. A benzo(f)quinolinium fused chromophore-based fluorescent probe for selective detection of c-myc G-Quadruplex DNA with a red emission and a large Stocks shift. Dyes and Pigments, 2019, 168: 334-340.
[6] Wang Ming-Qi*, Xu Jing, Zhang Lan, Liao Yue, Wei Heng, Yin Ying-Ying, Liu Qiang*, Zhang Lan. Tuning the selectivity of N-alkylated styrylquinolinium dyes for sensing of G-quadruplex DNA. Bioorganic & Medicinal Chemistry, 2019, 27: 552-559.
[7] Wang Ming-Qi*, Ren Gui-Ying, Zhao Shuang, Lian Guang-Chang, Chen Ting-Ting, Ci Yang, Li Hong-Yao. Development of a carbazole-based ?uorescence probe for G-quadruplex DNA: The importance of side-group effect on binding speci?city. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018,199, 441-447.
[8] Zhang Feng, Li Gan, Lv Fang-Lei, Jiang Guang-Bin, Wang Han-Xiang, Wang Ming-Qi*, Li Shuo*. A far-red ?uorescent probe for selective G-quadruplex DNA targeting. Tetrahedron Letters, 2018, 59, 3272–3278.
[9] Wang Ming-Qi*, Liu Xiao-Ning, Guo Zhong-Jian*, Feng chunlai*, Rui mengjie, Synthesis of quinolinium-based probes and studies of their effects for selective G-quadruplex DNA targeting, New Journal of Chemistry, 2018, 42: 4933-4939.
[10] Wang Ming-Qi*, Wu Yuan, Wang Zi-Yu, Chen Qiu-Yun*, Xiao Fu-Yan, Jiang Yu-Chi, Sang Amy, G-quadruplex DNA ?uorescence sensing by a bis-amine-substituted styrylquinolinium dye, Dyes and Pigments, 2017, 145: 1-6.
[11] Wang Ming-Qi*, Wang Zi-Yu, Yang Yi-Fan, Ren Gui-Ying, Liu Xiao-Ning, Li Shuo*, Wei Jian-Wei, Zhang Lan, Development of a light-up ?uorescent probe for HRAS G-quadruplex DNA. Tetrahedron Letters, 2017, 58: 3296-3300.
[12] Wang Ming-Qi*, Liu Shuo, Tang Cai-Ping, Raza Aun, Li Shuo*, Gao Lie-Xiong, Sun Jing*, Guo Song-Ping, Flexible amine-functionalized triphenylamine derivative as a ?uorescent “light-up” probe for G-quadruplex DNA, Dyes and Pigments, 2017, 136: 78-84.
[13] Wang Ming-Qi, Gao Lie-Xiong, Yang Yi-Fan, Xiong Xian-Ning, Zheng Zhao-Yi, Li Shuo*, Wu Yuan, Ma Lu-Lu, A triphenylamine derivative as a naked-eye and light-up fluorescent probe for G-quadruplex DNA, Tetrahedron Letters, 2016, 57(46): 5042-5046.
[14] Wang Ming-Qi*, Dong Juan, Zhang Huafan, Tang Zhuo*.Characterization of deoxyribozymes with site-speci?c oxidative cleavage activity against DNA obtained by in vitro selection, Organic & Biomolecular Chemistry, 2016, 14(7): 2347-2351.
[15] Wang Ming-Qi*, Zhu Wen-Xiang, Song Zhuan-Zhuan, Li Shuo*, Zhang Yong-Zhao, A triphenylamine-based colorimetric and ?uorescent probe with donor–bridge–acceptor structure for detection of G-quadruplex DNA, Bioorganic & Medicinal Chemistry Letters, 2015, 25(24): 5672-5676.
[16] Wang Ming-Qi, Zhang Hua-Fan, Zhang Wei, Zhao Yong-yun, Yasmeen Afshan, Zhou Li, Yu Xiao-Qi*, Tang Zhuo*, In vitro selection of DNA-cleaving deoxyribozyme with site-specific thymidine excision activity, Nucleic Acids Research, 2014, 42(14): 9262-9269.
[17] Wang Ming-Qi, Li Kun*, Xu Hao-Ran, Yu Xiao-Qi*, Imidazolium-based 1,1’-bi-2-naphthol fluorescent probe for ratiometric and selective detection of DNA in water, Analytical Methods, 2013, 5(21): 5903-5907.
[18] Wang Ming-Qi, Li Kun*, Hou Li-Ting, Wu Ming-Yu, Huang Zeng, Yu Xiao-Qi*, BINOL-Based fluorescent sensor for recognition of Cu(II) and sulfide anion in water, Journal of Organic Chemistry, 2012, 77(18): 8350-8354.
[19] Wang Ming-Qi, Zhang Ji, Zhang Yu, Zhang Da-Wei, Liu Qiang, Liu Jun-Liang, Lin Hong-Hui*, Yu Xiao-Qi*, Metal-free cleavage efficiency toward DNA by a novel PNA analog-bridged macrocyclic polyamine, Bioorganic & Medicinal Chemistry Letters, 2011, 21(19): 5866-5869.
[20] Wang Ming-Qi, Liu Jun-Liang, Wang Jing-Yi, Zhang Da-Wei, Zhang Ji, Streckenbach Frank, Tang Zhuo*, Lin Hong-Hui*, Liu Yan, Zhao Yu-Fen, Yu Xiao-Qi*, Site-selective DNA hydrolysis induced by a metal-free peptide nucleic acid-cyclen conjugate, Chemical Communications, 2011, 47(39): 11059-11061.
【发明专利】
[1] 王明齐，唐彩平，刘硕等，一种具有电荷转移特性的荧光探针及其制备方法和用途。
[2] 王明齐，马瑞，于全琦等，一种特异性检测平行构型G-四链体DNA探针的制备方法。
