个人简介

夏恒传，男，副研究员，硕士研究生导师
生物化学与分子生物学专业，博士



学习与工作经历：
1993 -1997年于曲阜师范大学生物系读本科，1997- 2004年于中国科学院上海生物化学与细胞生物学研究所硕博连读，2004-2008年于美国密歇根大学读博士后，2008年-至今于江苏大学生命科学研究院工作。
研究领域：

主要从事蛋白质的分离、鉴定、结构、功能与相互作用的研究。目前重点研究家蚕生长发育的调控机制、家蚕与家蚕核型多角体病毒BmNPV相互博弈的机制。发现MVB (Multivesicular body) 途径多种功能蛋白在家蚕变态发育、成虫期及胚胎发育期有显著的上调，但在整个幼虫期都有明显的下调，通过RNA干扰方法也证明它们在家蚕变态发育中发挥重要作用。这些功能蛋白也可能在BmNPV感染早期参与病毒在细胞内的运输过程及后期在细胞膜上出芽释放的过程。



研究课题：

1. 家蚕蛋白BVta1在MVB途径及杆状病毒BmNPV感染中的作用机制研究，国自然，**，201401-201712，主持。
2. 家蚕β-N-乙酰氨基葡萄糖苷酶2对核型多角体病毒蛋白糖基化的影响，国自然，**，201201-201412，参与，排名第2。
3. 家蚕氨基酸转运蛋白与其抗BmNPV功能的研究， 国自然，**， 201401-201612，参与，排名第2。
4. 铜绿假单胞菌铁载体pyoverdine的周质空间合成途径中重要蛋白质的结构及功能研究，国自然，**，201201-201512，参与，排名第2。
5. 铜绿假单胞菌铁载体合成途径关键蛋白质的结构及功能研究，国家重点实验室，M2008-07，200901-201012，主持。
6. 家蚕细胞MVB途径及在DNA病毒BmNPV出芽中的作用机制研究，省高校自然基金，10KJB180001，201009-201212，主持。



发表论文：



1. Xia H, Chen L, Shao D, Liu X, Wang Q, Zhu F, Guo Z, Gao L, Chen K.Vacuolar protein sorting 4 is required for silkworm metamorphosis. Insect Mol Biol. 2019 Oct;28(5):728-738. doi: 10.1111/imb.12586. Epub 2019 May
2. Wang Q, Ren M, Liu X, Xia H, Chen K. Peptidoglycan recognition proteins in insect immunity. Mol Immunol. 2019 Feb;106:69-76. doi: 10.1016/j.molimm.2018.12.021.
3. Xia H, Shao D, Liu X, Wang Q, Zhou Y, Chen K. Identification and Characterization of BmVta1, a Bombyx mori (Lepidoptera: Bombycidae) Homologue for Vta1 That is Up-Regulated in Development. J Insect Sci. 2017 May 1;17(3). doi: 10.1093/jisesa/iex055.
4. Chen L, Yang Y, Wang Y, Qiu L, Xia H, Wang A, Liu H, Shi H, Chen K. Proteomic Response of the Rat Liver in Differential Swimming Modes. Clin Exp Pharmacol Physiol. 2017 Dec 7. doi: 10.1111/1440-1681.12905.
5. Tang Q, Wu P, Hu Z, Yang Y, Qiu L, Liu H, Zhu S, Guo Z, Xia H, Chen K, Li G. Evidence for the role of BmNPV Bm65 protein in the repair of ultraviolet-induced DNA damage. J Invertebr Pathol. 2017 Oct;149:82-86. doi: 10.1016/j.jip.2017.08.004.
6. Yuan Z, Gao F, Bai G, Xia H, Gu L, Xu S. Crystal structure of PvdO from Pseudomonas aeruginosa. Biochem Biophys Res Commun. 2017 Feb 26;484(1):195-201.
7. 邵丹丹, 夏恒传, 陈波, 余毛毛，陈克平. 多功能分子机器 ESCRT 的研究进展. 江苏大学学报（医学版）, 2016(4).
8. Gao L, Li Q, Li R, Deng Z, Brady B, Xia N, Chen G, Zhou Y, Xia H, Chen K, Shi H. Protein determination using graphene oxide-aptamer modified gold nanoparticles in combination with Tween 80. Anal Chim Acta. 2016 Oct 19;941:80-86. doi: 10.1016/j.aca.2016.08.032.
9. Han, Y., Xia, H., Tang, Q., Lu, P., Ma, S., Yang, Y., Shao, D., Ma, Q. and Chen, K. (2014) The Bombyx mori nucleopolyhedrovirus Bm111 affects virulence but not virus replication. Curr Microbiol 69: 56-62.
10. Ma, S., Kang, Z., Lu, P., Yang, Y., Yao, Q., Xia, H. and Chen, K. (2015) Molecular and Physiological Characterization of Two Novel Multirepeat beta-Thymosins from Silkworm, Bombyx mori. PLoS One 10: e**.
11. Lü P#, Xia H#, Gao L, Pan Y, Wang Y, Cheng X, Lü H, Lin F, Chen L, Yao Q, Liu X, Tang Q, Chen K. V-ATPase Is Involved in Silkworm Defense Response against Bombyx mori Nucleopolyhedrovirus. PLoS One. 2013 Jun 18;8(6):e64962. (# co-first author)
12. 夏恒传，张春霞，冯凡，袁弋，周阳，刘晓勇，朱克明，姚勤，陈克平。多囊体生物发生和蛋白质分拣：ESCRT、Vps4、Ubiquitination一个都不能少. 生物化学与生物物理进展，2013, 40(2):103-117
13. Hengchuan Xia, Chunxia Zhang, Fan Feng, Yi Yuan, Xiaoyong Liu, Keming Zhu, Qin Yao, Keping Chen. The multivesicular body pathway: A newly discovered battlefield for gameplay between virus and host. African Journal of Microbiology Research, 2013, 7(11):913-920
14. Qin L#, Xia H#, Shi H, Zhou Y, Chen L, Yao Q, Liu X, Feng F, Yuan Y, Chen K. Comparative proteomic analysis reveals that caspase-1 and serine protease may be involved in silkworm resistance to Bombyx mori nuclear polyhedrosis virus. J Proteomics. 2012 Jun 27;75(12):3630-8. doi: 10.1016/j.jprot.2012.04.015. (# co-first author)
15. Xia H, Zhang C, Feng F, Yuan Y, Zhou Y, Liu X, Zhu K, Yao Q, Chen K. Molecular cloning, expression and characterization of a novel vacuolar protein sorting 4 gene in silkworm, Bombyx mori. Mol Biol Rep. 2012 Dec;39(12):10339-46
16. Xia H, Wu C, Xu Q, Shi J, Feng F, Chen K, Yao Q, Wang Y, Wang L. Molecular cloning and characterization of lactate dehydrogenase gene 1 in the silkworm, Bombyx mori. Mol Biol Rep. 2011 Mar;38(3):1853-60
17. Hengchuan Xia, Honggang Lv Keping Chen, Qin Yao, Peng Lv, Jun Li, Huiqing Chen and Lin Wang.Cloning and characterization of peptidylprolyl isomerase B in the silkworm, Bombyx mori. African Journal of Biotechnology. 2009,8(24):7148-7155
18. Pan Y, Xia H, Lü P, Chen K, Yao Q, Chen H, Gao L, He Y, Wang L. Molecular cloning, expression and characterization of Bmserpin-2 gene from Bombyx mori.Acta Biochim Pol. 2009;56(4):671-7
19. Xiao J, Xia H, Zhou J, Azmi IF, Davies BA, Katzmann DJ, Xu Z. Structural basis of vta1 function in the multivesicular body sorting pathway. Dev Cell. 2008, 14(1): 37-49
20. Xiao J, Xia H, Yoshino-Koh K, Zhou J, Xu Z. Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J Mol Biol. 2007, 374(3): 655-70
21. Xia HC, Li F, Li Z, Zhang ZC. Purification and characterization of Moschatin, a novel type I ribosome-inactivating protein from the mature seeds of pumpkin (Cucurbita moschata), and preparation of its immunotoxin against human melanoma cells. Cell Research, 2003, 13 (5): 369-74
22. Xia HC, Hu WG, Yang XX, Li F, Zhang ZC. Preparation and primary application of monoclonal antibodies against a novel ribosome-inactivating protein Moschatin from pumpkin seeds. Acta Biochim Biophys Sin (Shanghai). 2004, 36 (2): 105-10.