联系邮件 gaoli@ujs.edu.cn


研究方向和内容


新型生物芯片的制备及应用
高通量的研究工具——生物芯片，又称蛋白芯片或基因芯片，它们起源于DNA杂交探针技术与半导体工业技术相结合的结晶。该技术系指将大量探针分子固定于支持物上后与带荧光标记的DNA或其他样品分子（例如蛋白，因子或小分子）进行杂交，通过检测每个探针分子的杂交信号强度进而获取样品分子的数量和序列信息。


近期发表论文
(1) Li Gao, Lele Li, Xiaolong Wang, Peiwen Wu, Yang Cao, Bo Liang, Xin Li, Yuanwei Lin, Yi Lu and Xuefeng Guo. Graphene–DNAzyme junctions: a platform for direct metal ion detection with ultrahigh sensitivity. Chemical Science, 2015, 6(4), 2469–2473. (1区SCI, IF 9.21，Hot paper)
(2) Li Gao*, Qin Li, Raoqi Li, Lirong Yan, Yang Zhou, Keping Chen, Haixia Shi. Highly sensitive detection for proteins using graphene oxide-aptamer based sensors. Nanoscale, 2015, 7, 10903–10907. (1区SCI, IF 7.76, Cover paper)
(3) Li Gao*, Chaoqun Lian, Yang Zhou, Lirong Yan, Qin Li, Chunxia Zhang, Liang Chen, Keping Chen. Graphene oxide-DNA based sensors. Biosensors Bioelectronics, 2014, 60, 22–29. (1区SCI, IF 6.4)
(4) Li Gao*, Jingjie Cui, Yang Zhou, Liang Chen, Chunxia Zhang, Keping Chen, Chaoqun Lian, Lihua Li, Hong Li, and Jinke Liang. A strategy for sequencing based on rolling-circle amplification on a Microarray. Journal of Biomedical Nanotechnology, 2013, 9(4), 615–620. (1区，SCI, IF 7.5)
(5) Li Gao*, Qin Li, Raoqi Li, Zebin Deng, Brendan Brady, Ni Xia, Guimin Chen,Yang Zhou, Hengchuan Xia, Keping Chen, Haixia Shi. Protein determination using graphene oxide-aptamer modified gold nanoparticles in combination with Tween 80, Analytica Chimica Acta, 2016, http://dx.doi.org/10.1016/j.aca.2016.08.032. (1区SCI, IF 4.712)
(6) Li Gao*, Qin Li, Zebin Deng, Brendan Brady, Ni Xia, Yang Zhou, Haixia Shi. Highly sensitive protein detection via covalently linked aptamer to MoS2 and exonuclease-assisted amplification strategy, International Journal of Nanomedicine, 2017. (in press, 2区SCI, IF 4.30)
(7) Lirong Yan, Haixia Shi, Xiaowei Sui, Zebin Deng, Li Gao*. MoS2-DNA and MoS2 based sensors, RCS Advances, 2017,7(38), 23573–23582. (2区SCI, *通讯作者, IF 3.108)
(8) Ni Xia , Fan Feng, Cheng Liu, Raoqi Li, Wenwen Xiang, Haixia Shi, Li Gao*,The Detection of Mercury Ion Using DNA as Sensors Based on Fluorescence Resonance Energy Transfer, Talanta, 2018 (in press). (2区SCI, *通讯作者, IF 4.244)