邱立朋，博士、副教授、硕士生导师。沈阳药科大学药剂学博士学位，山东大学/翔宇药业股份有限公司博士后，牛津大学访问学者。江苏省药学会海洋药物专委会委员，江苏省预防医学会全球卫生专委会委员，中国药学会高级会员，沈阳药科大学学报首届青年编委，The second Youth Editorial Board Member of Asian Journal of Pharmaceutical Sciences，Youth Editorial Board Member of Biomaterials Translational，Youth Editorial Board Member of Nano TransMed。
即时信息请参照官网地址：https://slshe.jiangnan.edu.cn/info/1029/3874.htm
二、研究领域
纳米药物递送系统；生物药物新剂型；中药创新制剂；功能食品/医美新剂型
三、荣誉奖励
全国大学生挑战杯优秀指导教师
江南大学“青年至善学者”
江南大学教学成果特等奖
江南大学优秀毕业论文指导教师
高等学校科学研究技术进步二等奖
中国商业联合会科技进步一等奖
四、学术成果
（一）代表性项目
主持科技部重点研发计划项目子课题、国家自然科学基金青年项目、中国博士后科学基金面上（一等资助）项目、江苏省自然科学基金面上项目、山东省博士后创新项目等国家和省部级课题；负责开展新型小分子化合物可开发性研究、透明质酸冻干制剂的研发、延胡索乙素纳米微乳的研制、肠道癌前病变防控体系的建立与应用等校企合作研究课题。
（二）代表性论文
多年来，围绕多糖生物载体材料合成、智能药物递送系统构建、细胞和动物作用评价等进行研究，以一作/通讯作者在专业期刊发表论文60余篇，其中，SCI论文40余篇，累积引用超过2400次，H指数23。主要代表作如下：
[1] Enhanced Effect of pH-Sensitive Mixed Copolymer Micelles for Overcoming Multidrug Resistance of Doxorubicin. Biomaterials. 2014, 35(37): 9877-9887.
[2] Self-assembled pH-responsive Hyaluronic Acid-g-poly (L-histidine) Copolymer Micelles for Targeted Intracellular Delivery of Doxorubicin. Acta Biomaterialia. 2014, 10 (5): 2024-2035.
[3] cRGDyK modified pH responsive nanoparticles for specific intracellular delivery of doxorubicin. Acta Biomaterialia. 2016, 30: 285-298.
[4] pH-Sensitive degradable polymeric micelles for bio-triggered targeted anti-tumor drug delivery, J Control Release. 2017, 259: e86-e87.
[5] pH-triggered degradable polymeric micelles for targeted anti-tumor drug delivery. Mater Sci Eng C Mater Biol Appl. 2017, 78: 912-922.
[6] Designing heparan sulfate-based biocompatible polymers and their application for intracellular stimuli-sensitive drug delivery. Mater Sci Eng C Mater Biol Appl. 2019, 94: 465-476.
[7] Derma roller® microneedles-mediated transdermal delivery of doxorubicin and celecoxib co-loaded liposomes for enhancing the anticancer effect. Mater Sci Eng C Mater Biol Appl. 2019, 99:1448-1458.
[8] Elucidation of cellular uptake and intracellular trafficking of heparosan polysaccharide-based micelles in various cancer cells. Int J Biol Macromol. 2019, 130:755-764.
[9] Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery. Asian J Pharm Sci. 2020, 15(1): 83-94.
[10] A facile synthesis of uniform hollow MIL-125 titanium-based nanoplatform for endosomal esacpe and intracellular drug delivery. Chem Eng J, 2020, 396: 125246.
[11] Bacteria-mediated cancer therapies: opportunities and challenges. Biomater Sci. 2021, 9(17): 5732-5744.
[12] Biological role of heparan sulfate in osteogenesis: A review. Carbohydr Polym. 2021, 272: 118490.
[13] Carbon Nitride Nanosheets for Imaging Traceable CpG Oligodeoxynucleotide Delivery. ACS Appl Nano Mater, 2021, 4(8): 8546-8555.
[14] Stimuli-responsive, dual-function prodrug encapsulated in hyaluronic acid micelles to overcome doxorubicin resistance. Acta Biomater. 2021, 140:686-699.
[15] Dexamethasone microspheres and celecoxib microcrystals loaded into injectable gels for enhanced knee osteoarthritis therapy. Int J Pharm, 2022, 622, 121802.
[16] Enzyme-loaded glycogen nanoparticles with tumor-targeting Activatable host-guest supramolecule for augmented chemodynamic therapy. Int J Biol Macromol, 2022, 217: 878-889.
[17] Engineered bacteria combined with doxorubicin nanoparticles suppress angiogenesis and metastasis in murine melanoma models. Acta Biomater, 2023, 158:734-746.
[18] Oral delivery of layer-by-layer coated exosomes for colitis therapy. J Control Release, 2023, 354:635-650.
[19] Tumor-targeted glycogen nanoparticles loaded with hemin and glucose oxidase to promote tumor synergistic therapy. Int J Biol Macromol, 2023, 239:124363.
[20] A Purposefully Designed pH/GSH-Responsive MnFe-Based Metal-Organic Frameworks as Cascade Nanoreactor for Enhanced Chemo-Chemodynamic-Starvation Synergistic Therapy. Small. 2023: e2303403.
[21] Aminated yeast β-D-glucan for macrophage-targeted delivery of CpG oligodeoxynucleotides and synergistically enhanced cancer immunotherapy. Int J Biol Macromol, 2023, 253(Pt 3):126998.
[22] Nanoparticle/Engineered Bacteria Based Triple-Strategy Delivery System for Enhanced Hepatocellular Carcinoma Cancer Therapy. Int J Nanomedicine. 2024, 19:3827-3846.
[23] A Novel CaCu-Metal-Organic-Framework Based Multimodal Treatment Platform for Enhanced Synergistic Therapy of Hepatocellular Carcinoma. Adv Healthc Mater. 2024, 13(17):e2304000.
（三）国家发明专利
[1]一种注射用多功能复合型水凝胶及其制备方法，201810185988.1
[2]一种塞来昔布微晶、负载塞来昔布微晶的温敏性凝胶及其制备方法，202110773477.3
[3]伊曲康唑缓释微球的制备及应用，2022111974632
[4]一种壳聚糖缩硫酮活性氧清除水凝胶的制备方法和产品及应用，2023111165473
[5]一种塞来昔布聚合物前药的制备方法及应用，2023117556752
[6]一种口服递药系统及其在蛋白多肽类药物递送领域的应用，2024114584971
五、联系方式
通讯地址：江苏省无锡市蠡湖大道1800号江南大学生命科学与健康工程学院
邮编：214122
邮箱：qiulp@jiangnan.edu.cn
【以上资料更新日期】：2025年3月
