个人信息


个人简介
工作经历 (Professional Experience)
2018年9月-至今， 苏州大学 医学部基础医学与生物科学学院，生物信息学系，副研究员
2016年7月-2018年8月，苏州大学 系统生物学研究中心，副研究员
2012年8月-2016年7月，苏州大学 系统生物学研究中心，讲师

教育经历 (Educational Experience)2007年9月-2012年7月，中国科学院上海药物研究所， 药物设计，博士
2003年9月-2007年7月，山东中医药大学，中药学，学士



研究领域
1.蛋白质别构（Allostery)机制研究

运用分子模拟、生物网络模型及序列分析方法，开展靶标蛋白质的别构调控机制研究。



2. 计算机辅助药物设计

运用分子对接、药效团模型、骨架跃迁、组合库设计及从头设计等方法，开展靶向蛋白质激酶及表观遗传酶的药物设计。




3. 针对翻译后修饰（Post-Translational Modification, PTM)开展结构系统生物学研究。


基本信息






梁中洁
职称：副教授
院部/部门：医学部基础医学与生物科学学院
学历：博士
学位：博士研究生
毕业学校：中国科院学上海药物研究所
毕业专业：

联系方式


通讯地址：
邮政编码：
电子邮箱：zjliang@suda.edu.cn
联系电话：
传真号码：
办公地点：苏州大学独墅湖校区403-B304





科学研究


主持科研项目（Research grants)：

1.国家自然科学基金青年项目，**，靶向蛋白质精氨酸甲基转移酶PRMT1的药物发现与机理研究，2014/01-2016/12，23万元，已结题，主持2.江苏省属高校自然科学研究面上项目，13KJB520022, 靶向精氨酸甲基转移蛋白酶PRMT1的药物发现研究，2013/12-2015/12， 3.2万元，已结题，主持。

科研团队


合作团队胡广http://web.suda.edu.cn/huguang/index.html
严文颖http://web.suda.edu.cn/wyyan/index.html




论文


第一作者（包括并列一作）及通讯作者文章
(1) Wenying Yan; Daqing Zhang; Chen Shen; Zhongjie Liang(*); Guang Hu(*);Recent Advances on the Network Models in Target-based Drug Discovery, CurrentTopics in Medicinal Chemistry, 2018.10.4, 18(13): 1031~1043


(2) Liang Zhongjie; Hu Junchi; Yan Wenying;Jiang Hualiang; Hu Guang(*); Luo Cheng(*), Decipheringthe role of dimer interface in intrinsic dynamics and allosteric pathwaysunderlying the functional transformation of DNMT3A, Biochim Biophys Acta GenSubj, 2018.07, 1862(7): 1667~1679


(3) Xu, Pan; Hu, Guang; Luo, Cheng(*); Liang, Zhongjie(*), DNA methyltransferaseinhibitors: an updated patent review (2012-2015). , Expert Opinion onTherapeutic Patents, 2016.9, 26(9): 1017~1030


(4) Liang, Zhongjie; Hu, Guang(*), ProteinStructure Network-based Drug Design. , Mini Reviews in Medicinal Chemistry,2016, 16(16): 1330~1343


(5) Zhou, Ran ; Xie, Yiqian ; Hu, Hao ; Hu, Guang; Patel,Viral Sanjay; Zhang, Jin; Yu, Kunqian; Huang, Yiran; Jiang, Hualiang; Liang, Zhongjie(*); Zheng,Yujun George(*); Luo, Cheng(*), Molecular Mechanismunderlying PRMT1 Dimerization for SAM Binding and Methylase Activity. , Journalof Chemical Information and Modeling, 2015.12.28, 55(12): 2623~2632


(6) Lu, Junyan; Zeng, Hanlin; Liang, Zhongjie(并列一作); Chen, Limin; Zhang, Liyi;Zhang, Hao; Liu, Hong; Jiang, Hualiang; Shen, Bairong; Huang, Ming(*);Geng, Meiyu(*); Spiegel, Sarah; Luo, Cheng(*), Networkmodelling reveals the mechanism underlying colitis-associated colon cancer andidentifies novel combinatorial anti-cancer targets. , Scientific Reports,2015.10.8, 5: 14739~14739


(7) Jiang, Zhi; Liang,Zhongjie(并列一作); Shen, Bairong; Hu, Guang(*),Computational analysis of the binding specificities of PH domains. BioMedResearch International, 2015, 792904


(8) Xie, Yiqian ; Zhou, Ran ; Lian, Fulin; Liu, Yan; Chen,Limin; Shi, Zhe; Zhang, Naixia; Zheng, Mingyue; Shen, Bairong; Jiang, Hualiang; Liang, Zhongjie(*); Luo,Cheng(*), Virtual screening and biological evaluation of novel smallmolecular inhibitors against protein arginine methyltransferase 1 (PRMT1),Organic and Biomolecular Chemistry, 2014.12.21, 12(47): 9665~9673


(9) Zhu, Kongkai; Kong, Xiangqian; Zhao, Dan; Liang, Zhongjie(*); Luo,Cheng(*), c-MET kinase inhibitors: a patent review (2011 - 2013). ExpertOpinion on Therapeutic Patents, 2014.2 24(2): 217~230


(10) Liang, Zhongjie; Ai, Jing; Ding, Xiao; Peng,Xia; Zhang, Dengyou; Zhang, Ruihan; Wang, Ying; Liu, Fang; Zheng, Mingyue;Jiang, Hualiang; Liu, Hong(*); Geng, Meiyu(*); Luo, Cheng(*),Anthraquinone Derivatives as Potent Inhibitors of c-Met Kinase and theExtracellular Signaling Pathway. , ACS Medicinal Chemistry Letters, 2013.4.11,4(4): 408~413


(11) Liang, Zhongjie; Ding, Xiao; Ai, Jing; Kong,Xiangqian; Chen, Limin; Chen, Liang; Luo, Cheng(*); Geng, Meiyu(*);Liu, Hong(*); Chen, Kaixian; Jiang, Hualiang, Discovering potentinhibitors against c-Met kinase: molecular design, organic synthesis andbioassay. , Organic and Biomolecular Chemistry, 2012.1.14, 10(2): 421~430


(12) Zhongjie Liang; Liying Zhang; Lianchun Li;Jun Liu; Hongling Li; Luyong Zhang; Limin Chen; Keguang Cheng; Mingyue Zheng;Xiaoan Wen; Pu Zhang; Jia Hao; Yanchun Gong; Xia Zhang; Xiaoyun Zhu; Jun Chen;Hong Liu; Hualiang Jiang; Cheng Luo(*); Hongbin Sun(*), Identificationof pentacyclic triterpenes derivatives as potent inhibitors against glycogenphosphorylase based on 3D-QSAR studies , European Journal of MedicinalChemistry, 2011.6, 46(6): 2011~2021


(13) Liang, Zhongjie; Li, Lianchun; Wang,Yuanyuan; Chen, Limin; Kong, Xiangqian; Hong, Yao; Lan, Lefu; Zheng, Mingyue;Guang-Yang, Cai; Liu, Hong; Shen, Xu; Luo, Cheng(*); Li, Keqin Kathy(*);Chen, Kaixian; Jiang, Hualiang, Molecular basis of NDM-1, a new antibioticresistance determinant. , PLos One, 2011, 6(8)


(14) Zhongjie Liang; Dengyou Zhang; Jing Ai;Limin Chen; Hengshuai Wang; Xiangqian Kong; Mingyue Zheng; Hong Liu(*);Cheng Luo(*); Meiyu Geng(*); Hualiang Jiang; KaixianChen, Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazidederivatives against c-Met kinase , Bioorganic & Medicinal ChemistryLetters, 2011.6.15, 21(12): 3749~3754


(15) Liang, Zhongjie; Shi, Ting; Ouyang, Sisheng;Li, Honglin; Yu, Kunqian; Zhu, Weiliang; Luo, Cheng(*); Jiang,Hualiang(*), Investigation of the catalytic mechanism of Sir2 enzymewith QM/MM approach: SN1 vs SN2? , Journal of Physical Chemistry B Materials,2010.9.16, 114(36): 11927~11933

荣誉奖励






开授课程


本科生教学： 代谢组学
研究生教学： 蛋白质结构与功能
招生信息


本课题组主要从事蛋白质结构相关的生物信息学研究及药物设计研究，欢迎有兴趣的学生积极加入！