姓名:周亮
职称职务:副研究员
电子邮箱:liangzhou@suda.edu.cn
办公地址:云轩楼1330
个人简历:
学习经历:
2004.09-2008.07内蒙古大学,本科
2008.09-2013.07中国科学技术大学,博士
研究经历:
2013.10-2016.03美国国立卫生研究院, 博士后
2016.08-2019.07 苏州大学助理研究员
2019.07-至今 苏州大学副研究员
研究方向:
蛋白质降解和修饰
神经相关疾病的分子机制
主要研究成果:
运用分子、细胞、电生理技术研究神经疾病,在Nat. Commun, cell reports,MolecularNeurobiology,Neuroscience等杂志上发表英文论文。
代表性论文:
1.Gu X※, Mao X※, Lussier MP※, Hutchison MA※,Zhou L, Hamra FK, Roche KW, Lu W. GSG
2.Gu X,Zhou L, Lu W. An NMDA receptor-dependent mechanism underlies inhibitory synapse development.Cell Reports14, 471-478 (2016).
3.Zhou L※, Wang H※, Ren H, Hu Q, Ying Z, Wang G. Bcl-2 decreases the affinity of SQSTM1/p62 to Poly-Ubiquitin chains and suppresses the aggregation of misfolded protein in Neurodegenerative disease.MolecularNeurobiology52, 1180-1189 (2015).
4.Zhou L, Wang H, Chen D, Gao F, Ying Z, Wang G. p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine.International Journal of Molecular Sciences15, 14997-15010 (2014).
5.Zhou L, Wang H, Wang P, Ren H, Chen D, Ying Z, Wang G. Ataxin-3 protects cells against H2O2-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax.Neuroscience243, 14-21 (2013).
6.Zhou L, Wang HF, Ren HG, Chen D, Gao F, Hu QS, Fu C, Xu RJ, Ying Z, Wang GH. Bcl-2-dependent upregulation of autophagy by sequestosome 1/p
7.Wang P, Li B,Zhou L, Fei E, Wang G. The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins.Neuroscience190, 43-55 (2011).