张乐帅教授 博士生导师
电子邮箱：zhangls@suda.edu.cn
个人简介：
张乐帅，苏州大学放射医学与防护学院教授，美国资格认证毒理学家（Diplomatof the American Board of Toxicology, DABT，2015-）、英国注册毒理学家（UK Register of Toxicologists, UKRT,2018-）、欧洲注册毒理学家（European Register of Toxicologists，ERT,2018-）、苏州大学卫生与环境技术研究所纳米技术产品评价中心主任、中国民主建国会成员。
2002年获得华东理工大学生物化学学士学位；后由华东理工大学及中国科学院上海生化细胞所联合培养，参与Wnt细胞信号转导通路研究，于2005年获得硕士学位。同年赴美学习，于美国北卡州立大学（North Carolina State University）从事纳米材料的皮肤安全性研究，包括其透皮吸收能力、对皮肤角质细胞及免疫细胞的功效及安全性评价等，2010年获博士学位。2010年起于美国食品药物管理局（US FDA）开展糖尿病药物副作用的机制研究与评价，及纳米材料的毒性评估。2012年于美国堪萨斯州立大学（Kansas State University）纳米技术创新中心聘为研究助理教授，从事纳米毒理学与从事食品添加剂及化妆品成份安全性研究。2014年受聘苏州大学，从事生物医学组织工程、纳米/药物毒理学及中药肿瘤免疫学研究，并推进纳米技术相关产品的安全评价标准化进程。
至今共发表文章41篇（引用1400余次），其中SCI文章38篇，一作或通讯作者文章30篇；部分工作被Science Daily等杂志和网站报道；主编专业书籍1本，参编英文书籍2本。获得国自然面上基金3项、青年基金1项、教育部回国留学人员启动基金1项。目前为美国毒理协会（Society of Toxicology）会员（2007-）、Sigma Xi科学研究协会会员（2009-2013）、中国毒理学会会员（2015-）、江苏省毒理学会会员（2015-）、中国化妆品科协会员（2016-）。学术任职为全国纳米技术标委会WG3委员（2019-）、中国毒理学会中药毒理专委会青年委员（2018-）、中国医疗器械行业协会整形美容外科器材专业委员会委员（2018-）、中国毒理学会纳米毒理专业委员会委员（2016-）、Toxicology and Industry Health副主编（2016-）、美国毒理协会纳米毒理分会执行委员（2012–2013）、美国毒理协会教育委员会执行委员（2011–2015）。学术服务包括Toxicological Sciences、Biomaterials、Nanotoxicology等29种国际毒理、药理及材料相关杂志审稿人，共计审稿近180次。社会服务包括为药品与医械的科研转化、产品质控、安全评价提供建议。
研究方向：
本研究小组研究方向为药理与毒理学，方向涉及两大部分。一、纳米毒理学——新型影像剂及放射防护相关的金属无机纳米材料肝肾毒性机制探索，并通过体外替代方法予以安全评价；二、免疫药理学——中药活性多糖成份的提纯鉴定、体内外免疫活性分析，及中药标准化；研究活性多糖纳米制剂如何协同放化疗治疗肿瘤及其中免疫机制。
教学经历：
负责苏州大学医学部2013级留学生专业选修课《皮肤毒理学与化学品》全英文课程（为2013级最受留学生好评的英文课程）、学校通识课《日常摄影与显微镜》、放射医学与防护学院的研究生第二课堂活动（已80期）。
科研项目：
主持国家自然科学基金面上项目（#**、#**）、教育部留学回国基金；国家自然科学基金面上项目（#**）与青年基金（#**）已结题
发表文章：
1) Pang G, Chen C, Liu Y, Jiang T, Yu H, Wu Y, Wang Y, Wang FJ*, Liu Z*, Zhang L*.Bioactive Polysaccharide Nanoparticles Improve Radiation-Induced Abscopal Effect through Manipulation of Dendritic Cells.ACS Appl Mater Interfaces. 2019 Oct 31. doi: 10.1021/acsami.9b16814.
2) Yu H, Yang Y, Jiang T, Zhang X, Zhao Y, Pang G, Feng Y, Zhang S, Wang F, Wang Y, Wang Y, Zhang L*.2019. Effective Radiotherapy in Tumor Assisted by Ganoderma lucidum Polysaccharide-Conjugated Bismuth Sulfide Nanoparticles through Radiosensitization and Dendritic Cell Activation.ACS Appl Mater Interfaces. 11(31):27536-27547.
3) Cao Y, Huang H, Chen L, Du H, Cui J, Zhang L*, Lee B, Cao Q*. 2019. Enhanced Lysosomal Escape of pH-Responsive PEI-Betaine Functionalized Carbon Nanotube for the Co-delivery of Survivin siRNA and Doxorubicin. ACS Applied Materials & Interfaces11(10):9763-9776.
4) Pang G, Zhang S, Yu H, Wu Y, Jiang T, Wang F*, Wang Y*, Zhang L*. 2019. Immunoactive Astragalus Polysaccharide Functionalized Gold Nanocomposites Promote Dendritic Cell Stimulation and Anti-tumor Effect with Elicited Memory T-cell Responses. Nanomedicine14(10):1291-1306.
5) Zhang S, Pang G, Chen C, Qin J, Yu H, Liu Y, Zhang X, Song G, Zhao J, Wang F*, Wang Y*, Zhang L*. 2019. Effective Cancer Immunotherapy by Ganoderma Lucidum Polysaccharide-Gold Nanocomposites through Dendritic Cell Activation and Memory T cell Response. Carbohydrate Polymer 205:192-202.
6)Zhang L*, Monteiro-Riviere NA Toxicity Assessment of Six Titanium Dioxide Nanoparticles in Human Epidermal Keratinocytes. 2018. Cutaneous and Ocular Toxicology. 2018 Sep 28:1-29.
7) Song ZT, Zhang L, Fan LQ, Kong JW, Mao JH, Zhao J, Wang FJ. 2018. Enhanced anticancer effect of MAP30-S3 by cyclosproin A through endosomal escape. Anti-cancer Drugs 29(8):736-747.
8) Pan G, Wang F*, Zhang L*. 2018. Direct Killing or Immunoregulatory Effects of Natural Polysaccharides in Cancer Treatment. Carbohydrate Polymer 195: 243–256.
9) Liu Y, Yu H, Zhang X, Wang Y, Zhao J, Shi H, Li R, Wang Y*, Zhang L*. 2018. The Protective Role of Autophagy in Nephrotoxicity Induced by Bismuth Nanoparticles Through AMPK/mTOR Pathway. Nanotoxicology 6:1-16.
10) Zhang X, Yang L, Liu Y, Song Z, Zhao J, Chen D, Yu Huan, Li R, Wang Y, Yang K, Chen Y, Xia M, Zhang L*. 2018. Detection of Nanocarrier Potentiation on Drug Induced Phospholipidosis in Cultured Cells and Primary Hepatocyte Spheroids by High Content Imaging and Analysis. Toxicology and Applied Pharmacology 348: 54–66.
11) Chen D, Yang L, Chen X, Zhang X, Liu Y, Guo Z*, Zhang L*. 2018. Automated contour analysis of multi-cellular spheroids spreading through high content imaging. Physical Biology 24: 15:026006
12) Liu Y, Shen C, Zhang X, Yu H, Wang F, Wang Y*, Zhang L*.2018. Exposure and Nephrotoxicity Concern of Bismuth with the Occurrence of Autophagy. Toxicology and Industrial Health 34:188–199
13) Li J, He X, Zou Y, Chen D, Yang L, Rao J, Chen H, Chan M CW, Guo Z*,Zhang L*, Chen C. 2017. Mitochondria-Targeted Platinum(II) Complex: Dual Inhibitory Activities on Tumor Cell Proliferation and Migration/Invasion via Intracellular Trafficking of β-catenin. Metallomics 9:726-733.
14) Liu Y, Zhuang J, Zhang X, Le C, Zhu N, Yang L, Wang Y, Chen T, Wang Y*, Zhang L* 2017. Autophagy Associated Cytotoxicity and Cellular Uptake Mechanisms of Bismuth Nanoparticles in Human Kidney Cells. Toxicology Letters 275: 39-48.
15) Chen D, Monteiro-Riviere NA, Zhang L*. 2017. Intracellular imaging of quantum dots, gold, and iron oxide nanoparticles with associated endocytic pathways. WIREs Nanomedicine and Nanobiotechnology 9(2).
16) Yang L, Zhong X, Li Q, Zhang X, Wang Y, Yang K, Zhang L*. 2017. From the Cover: Potentiation of Drug-Induced Phospholipidosis In Vitro through PEGlyated Graphene Oxide as the Nanocarrier. Toxicological Sciences 156:39–53.
17) Wang Y, Liu Y, Wu Y, Shen J, Lv L, Li L, Yang L, Zeng J, Wang Y, Zhang L*, Li Z*, Gao M*, Chai Z. 2016. BSA-Mediated Synthesis of Bismuth Sulfide Nanotheranostic Agents for Tumor Multimodal Imaging and Thermoradiotherapy. Advanced Functional Materials 26: 5335–5344.
18)Zhu N, Lv X, Wang Y, Li J, Liu Y, Lu W, Yang L, Zhao J, Wang F, Zhang L*. 2016. Comparison of immunoregulatory effects of polysaccharides from three natural herbs and cellular uptake in dendritic cells. International Journal of Biological Macromolecules 93:940–951.
19) Wang Y*, Zhu L, Wang Y, Li L, Lu Y, Shen L*, Zhang L*. 2016. Ultrasensitive GSH-Responsive Ditelluride-Containing Poly(ether-urethane) Nanoparticles for Controlled Drug Release. ACS Applied Materials & Interfaces 8: 35106–35113.
20) Lv X, Chen D, Yang L, Zhu N, Li J, Zhao J, Hu Z, Wang F*, Zhang L*. 2016. Comparative Studies on the Immunoregulatory Effects of Three Polysaccharides Using High Content Imaging System. International Journal of Biological Macromolecules 86:28–42.
21) Zhang L, Koci J, Brett J, Riviere JE, Monteiro-Riviere NA. 2015. Safety Assessment of Potential Food Ingredients in Canine Hepatocytes. Food and Chemical Toxicology 78:105–15.
22) Zhang L, Shea KI, Xu L, Stewart S, Zhang J, Rouse RL. 2014. Autophagy in pancreatic acinar cells in caerulein treated mice: Immunolocalization of related proteins and their potential as markers of pancreatitis. Toxicologic Pathology 42, 435–457.
23) Zhang L, Monteiro-Riviere NA. 2013. Use of confocal microscopy for nanoparticle drug delivery through skin. Journal of Biomedical Optics. 18(6):061214
24) Zhang L, McMahon Tobin GA, Rouse RL. 2012. Oleic acid and glucose regulate glucagon-like peptide 1 receptor expression in a rat pancreatic ductal cell line. Toxicology and Applied Pharmacology 264: 274–283.
25) Zhang L, B?umer W, Monteiro-Riviere NA. 2011. Cellular uptake mechanisms and toxicity of quantum dots in dendritic cells. Nanomedicine. 6: 777–791.
26)Zhang L, Monteiro-Riviere NA. 2010. Lectins modulate multi-walled carbon nanotubes cellular uptake in human epidermal keratinocytes. Toxicology In Vitro 24: 546–555.
27)Zhang L, Yang J, Barron AR, Monteiro-Riviere NA. 2009. Endocytic mechanisms and toxicity of a functionalized fullerene in human cells. Toxicology Letters 191: 149–157.
28) Zhang L, Monteiro-Riviere NA. 2009. Mechanisms of quantum dot nanoparticle cellular uptake. Toxicological Sciences. 110: 138–155.
29) Zhng L, Monteiro-Riviere NA. 2008. Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin Pharmacology and Physiology 21:166 –180.
30) Zhang L, Yu WW, Colvin VL, Monteiro-Riviere NA. 2008. Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicology and Applied Pharmacology 228:200–211.
31) Zhang L, Zeng L, Barron AR, Monteiro-Riviere NA. 2007. Biological interactions of functionalized single-wall carbon nanotubes in human epidermal keratinocytes. International Journal of Toxicology 26:103–113.
（更新于2019年11月08日）