陶莎莎
姓名：陶莎莎（1983.6-），女，黑龙江省双城市人； 职称：特聘副教授
2006.09－2011.06 中国医科大学公共卫生学院 硕博连读
2001.09-2006.06 中国医科大学预防医学 本科

2. 工作经历

2009.06-2011.06 美国亚利桑那大学 访问****
2011.06-2015.09 美国亚利桑那大学 博士后

3. 研究方向

劳动卫生与环境卫生


4. 承担课题情况

特聘副教授启动基金

5. 发表论文

1. Tao S, Tillotson J, Wijeratne EM, Xu YM, Kang M, Wu T, Lau EC, Mesa C, Mason DJ, Brown RV, La Clair JJ, Gunatilaka AA, Zhang DD, Chapman E. Withaferin A Analogs That Target the AAA+ Chaperone p97.ACS Chem Biol. 2015 Jun 3. [Epub ahead of print]2. Tao S, Wang S, Moghaddam SJ, Ooi A, Chapman E, Wong PK, Zhang DD. Oncogenic KRAS confers chemoresistance by upregulating NRF2.Cancer Res. 2014 Dec 15;74(24):7430-41. doi: 10.1158/0008-5472.CAN-14-1439. Epub 2014 Oct 22.
3. Tao S, Zhu L, Lee P, Lee WM, Knox K, Chen J, Di YP, Chen Y. Negative control of TLR3 signaling by TICAM1 down-regulation. Am J Respir Cell Mol Biol. 2012 May; 46(5):660-7 {impact factor: 4.148}-highlighted4. Tao S, Zheng Y, Lau A, Jaramillo MC, Chau BT, Lantz RC, Wong PK, Wondrak GT, Zhang DD. Tanshinone I activates the Nrf2-dependent antioxidant response and protects against As(III)-induced lung inflammation in vitro andin vivo.Antioxid RedoxSignal. 2013 Feb 8. [Epub ahead of print] {impact factor: 7.189}-highlighed
5. Tao S, Donna D. Zhang, and Georg T. Wondrak. The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV. Redox Biology.
6. Long M, Tao S, Rojo de la Vega M, Jiang T, Wen Q, Park SL, Zhang DD, Wondrak GT. Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde.Cancer Prev Res (Phila). 2015 May;8(5):444-54. doi: 10.1158/1940-6207.CAPR-14-0359. Epub 2015 Feb 23.
7. Chen W, Wang H, Tao S, Zheng Y, Wu W, Lian F, Jaramillo M, Fang D, Zhang DD. Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival. Cell Cycle. 2013 Jul 15;12(14):2321-8. {impact factor:5}
8. Shuxi Qiao, Tao S, Montserrat Rojo de la Vega, sophia L Park, amanda a Vonderfecht, suesan L Jacobs, Donna D Zhang, and Georg T Wondrak. The antimalarial amodiaquine causes autophagic- lysosomal and proliferative blockade sensitizing human melanoma cells to starvation-and chemotherapy-induced cell death. autophagy 9:12, 1–16; December 2013. {impact factor: 12}
9. Alexandria Lau, Yi Zheng, Tao S, Huihui Wang, Samantha A. Whitman, Eileen White, and Donna D. Zhang. Arsenic inhibits autophagic flux activating the Nrf2-Keap1 pathway in a p62-dependent manner. Molecular Cell Biology. [Accepted] {impact factor: 5}
10. Zheng Y, Tao S, Lian F, Chau BT, Chen J, Sun G, Fang D, Lantz RC, Zhang DD. Sulforaphane prevents pulmonary damage in response to inhaled arsenic by activating the Nrf2-defense response. Toxicol Appl Pharmacol. 2012 Dec 15; 265(3):292-9. {impact factor: 4.447}
11. Chen W, Jiang T, Wang H, Tao S, Lau A, Fang D, Zhang DD. Does Nrf2 Contribute to p53-Mediated Control of Cell Survival and Death? Antioxid Redox Signal. 2012 Dec 5;17(12):1670-5. {impact factor: 8.45}
12.Zhu L, Lee P, Yu D, Tao S, Chen Y. Cloning and Characterization of Human MUC19 Gene.Am J Respir Cell Mol Biol. 2011 Aug;45(2):348-58. {impact factor: 5.13}
13. Liu F, Weng D, Chen Y, Song L, Li C, Dong L, Wang Y, Tao S, Chen J. Depletion of CD4+CD25+Foxp3+ regulatory T cells with anti-CD25 antibody may exacerbate the 1,3-β-glucan-induced lung inflammatory reponse in mice. Arch Toxicol. 2011 Nov;85(11):1383-94.
14. Chen Y, Wang X, Weng D, Tian L, Lv L, Tao S, Chen J. A TSP-1 synthetic peptide inhibits bleomycin-induced lung fibrosis in mice. Exp Toxicol Pathol.2009; 61(1):59-65.
15. Chen Y, Wang X, Weng D, Lv L, Tao S, Chen J. A TSP-1 functional fragment inhibits activation of latent transforming growth factor-1 derived from rat alveolar macrophage after bleomycin treatment. Exp Toxicol Pathol, 2009, 61(1): 67-73
16. 陈莹, 王欣, 翁东, 陶莎莎, 吕丽娜, 田璐佳, 陈杰. 血小板反应素-1的Ⅰ型重复序列功能肽段对小鼠肺纤维化的抑制作用. 中华劳动卫生职业病杂志, 2009, 27（1）: 45-47
17. 陈莹，王欣，翁东，陶莎莎，吕丽娜，陈杰. 血小板反应素-1功能片段对对非活化形式的转化生长因子-β1的抑制作用. 中华劳动卫生职业病杂志, 2009，27（2）: 98-100

6. 参与课题：
1.国家自然科学基金项目:Th17在实验性矽肺纤维化发生发展中的免疫调控机制（编号:**），经费：33万，期限：2011.01-2013.12
2.国家自然科学基金项目：Th17在矽肺模型中对矽尘诱发自身免疫调控机制的研究（编号:**），经费：33万，期限：2011.01-2013.12
3 国家自然科学基金:Tregs对1→3-β-Glucan所致变态反应性肺泡炎Th应答及Th极化的调控机制（编号:**）， 经费：31万，期限：2008.01-2010.12
4. 国家自然科学基金项目:Tregs在实验性矽肺发生发展中调控Th应答的效应机制（编号：**）， 经费：20万，期限：2009.01-2011.12
5. “Regulation of MUC19 by Th2 cytokine in airway epithelium” ； Principal Investigator: Yin Chen, Ph.D. Agency: NIH/NIAID Type: R01 AI061695-01. Period: 09/13/07-09/12/12. $1,250,000 (total direct cost). The long-term goal of this project is to determine the molecular mechanism underlying mucous cell development in asthma and asthma exacerbation.
6. The protective role of Nrf2 in arsenic-induced toxicity and carcinogenicity. Principal Investigator: Donna D. Zhang, Ph.D. Agency: NIH/NIAID Type:R01 ES015010-05. Period: 09/1/2006 – 08/31/2012. $1,625,000 (total direct cost). The major goals of this project are to define the protection of the transcription factor Nrf2 against arsenic-induced toxicity and carcinogenicity.
7. American Cancer Society $600,000. Regulation of the transcription factor Nrf2 by chemopreventive compounds. Principal Investigator: Donna D. Zhang, Ph.D. Type:RSG-07-154-01-CNE. Period: 07/1/2007-06/31/2012. The major goals of this project are to define the mechanism of Nrf2 regulation in response to the treatment of chemopreventive compounds.
8. Topical Nrf2-activators for skin photoprotection and chemoprevention of skin cancer. Principal Investigator: Donna D. Zhang and George Wondrak. Type: SWEHSC pilot research grant ES06694 2006 $40,000 (total direct cost).

7.联系方式：

Email address：taoqishu619@126.com