个人简介
理学博士。1969年1月生。苏州大学****，苏州丝美特生物技术有限公司创始人兼首席科学家，美国Tufts 大学生物医学系助理教授，苏州工业园区纳米领军人才、姑苏领军人才。现任职苏州大学纺织与服装工程学院及现代丝绸国家工程实验室，创建了苏州大学-Tufts大学生物医用材料联合实验室。主要研究天然丝素蛋白生物材料的工业化制备及其在组织工程修复、药物递送、生物3D打印、生物传感器和日用品工业中的应用。正在主持国家自然科学基金中德科技合作项目、国家自然科学基金面上项目和工业横向项目。王晓沁于1991年获得山东大学微生物工程专业学士学位，1998年获得北京协和医科大学分子生物学硕士学位，2004年获得荷兰格罗宁根（Groningen）大学博士学位。曾先后任职荷兰贝尔美德（BioMaDe）生物技术公司、美国塔夫茨（Tufts）大学生物医学系、美国ETEX生物技术公司、美国Ekteino Laboratory, Cocoon Biotech等生物技术公司，担任新产品和新技术研发负责人。

研究方向及主讲课程
主要研究方向：丝素蛋白基药物缓释及组织修复；功能化丝素蛋白生物材料
近五年主持的科研项目
1. 国家重点研发计划“生物医用材料研发及组织器官修复替代” （项目参与） 2017-2021
2. 国家自然科学基金中德合作项目：有效利用巨噬细胞可塑性促进骨再生 （项目主持） 2015年至今
3. 国家自然科学基金面上项目: 抗氧化剂修饰的丝素蛋白生物材料对细胞生长和功能的调控（项目主持）**年
4. 姑苏领军创业人才项目：丝素蛋白止血防粘连材料的开发和应用 （项目主持）2013-2017年
近五年发表的代表性论文和教材
2014-2017发表论文：
1.Wu J, Xie X, Zheng Z, Li G, Wang Y, Wang X*. Effect of pH on polyethylene glycol (PEG)-induced silk microsphere formation for drug delivery. Materials Science and Engineering: C Materials for Biological Applications. 2017 Nov 1;80:549-557.
2.Liu Y, Zheng Z, Guo S, Li G, Wang X*, Kaplan DL. DNA preservation in silk. Biomaterials Science. 2017 Jun 27;5(7):1279-1292.
3.Yang L, Zheng Z, Qian C, Wu J, Liu Y, Guo S, Li G, Liu M, Wang X, Kaplan DL. Curcumin-functionalized silk biomaterials for anti-aging utility. J Colloid Interface Sci. 2017;496:66-77 (SCI, IF: 3.368)
4.Luo T, Yang L, Wu J, Zheng Z, Li G, Wang X^*, Kaplan DL. Stabilization of Natural Antioxidants by Silk Biomaterials. ACS Appl Mater Interfaces. 2016;8:13573-13582. doi: 10.1021/acsami.6b01636. Epub 2016 May 17. PMID: ** (SCI, IF: 7.145; Field-Weighted Citation Impact: 0.83; cited number: 2)
5.Wu J, Zheng Z, Li G, Kaplan DL, Wang X^*. Control of silk microsphere formation using polyethylene glycol (PEG). Acta Biomaterialia. 2016;39:156-168. doi: 10.1016/j.actbio.2016.05.019. Epub 2016 May 12. PMID: ** (SCI, IF: 6.025; Field-Weighted Citation Impact: 1.98; cited number: 3)
6.Zheng Z, Guo S, Liu Y, Wu J, Li G, Liu M, Wang X^*, Kaplan D. Lithium-free processing of silk fibroin. J Biomater Appl. 2016;31:450-463. doi: 10.1177/3259. Epub 2016 Jun 12. PMID: ** (SCI, IF: 2.764; Field-Weighted Citation Impact: 0; cited number: 0)
7.Yu D，Sun C, Zheng Z, Wang X, Chen D, Wu H, Wang X^*, Shi F. Inner ear delivery of dexamethasone using injectable silk-polyethylene glycol (PEG) hydrogel. Int J Pharm. 2016;503:229-237. doi: 10.1016/j.ijpharm.2016.02.048. Epub 2016 Mar 10. PMID: ** (SCI, IF: 3.65; Field-Weighted Citation Impact: 5.03; cited number: 3)
8.Li G, Li F, Zheng Z, Luo T, Liu J, Wu J, Wang X^*, Kaplan DL. Silk microfiber-reinforced silk composite scaffolds: fabrication, mechanical properties, and cytocompatibility. J Mater Sci. 2016;51:3025-3035 (SCI, IF: 2.302; Field-Weighted Citation Impact: 2.17; cited number: 2)
9.Wang Y, Liang M, Zheng Z, Shi L, Su B, Liu J, Kaplan DL, Zhang B, Wang X^*. Adhesion Prevention after Laminectomy using Silk-polyethylene glycol (PEG) Hydrogels. Adv Healthc Mater. 2015;4:2120-2127 Aug 24. doi: 10.1002/adhm.. [Epub ahead of print] PMID: ** (SCI, IF: 5.76; Field-Weighted Citation Impact: 0.33; cited number: 1)
10.Lu D, Zheng Z, Guo S, Wang C, Kaplan DL, Wang X^*. Binding quantum dots to silk biomaterials for optical sensing. J Sensors. 2015:819373 (SCI, IF: 0.712; Field-Weighted Citation Impact: 0.45; cited number: 1)
11.Zheng Z, Liu M, Guo S, Wu J, Lu D, Li G, Liu S, Wang X^*, Kaplan DL. Incorporation of quantum dots in silk biomaterials for fluorescence imaging. J Mater Chem B Mater Biol Med. 2015;3:6509-6519. PMID: ** PMCID: PMC** (SCI, IF: 4.872; Field-Weighted Citation Impact: …; cited number: 3)
12.Li G, Liu J, Zheng Z, Wang X^*, Kaplan DL. Structural Mimetic Silk Fiber-Reinforced Composite Scaffolds Using Multi-Angle Fibers. Macromol Biosci. 2015;15:1125-1133. doi: 10.1002/mabi.. Epub 2015 Apr 16. PMID: ** (SCI, IF: 3.85; Field-Weighted Citation Impact: 0.54; cited number: 2)
13.Li G, Li Y, Chen G, He J, Han Y, Wang X^*, Kaplan DL. Silk-based biomaterials in biomedical textiles and fiber-based implants. Adv Healthc Mater. 2015;4:1134-1151 doi: 10.1002/adhm.. Epub 2015 Mar 13. PMID: ** PMCID: PMC** (SCI, IF: 5.76; Field-Weighted Citation Impact: 1.3; cited number: 11)
14.Lovett ML, Wang X, Yucel T, York L, Keirstead M, Haggerty L, Kaplan DL. Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics. Eur J Pharm Biopharm. 2015;95:271-278 doi: 10.1016/j.ejpb.2014.12.029. Epub 2015 Jan 12. PMID: ** (SCI, IF: 4.245; Field-Weighted Citation Impact: 3.07; cited number: 9)
15.Wang X^*, Partlow B, Liu Jian, Zheng Z, Su Bo, Wang Y, Kaplan D. Injectable silk-polyethylene glycol hydrogels. Acta Biomaterialia. 2015;12:51-61 doi: 10.1016/j.actbio.2014.10.027. Epub 2014 Oct 25. PMID: ** (SCI, IF: 6.025; Field-Weighted Citation Impact: 3.9; cited number: 15)
16.Zhou Shun, Huang Wenwen, Belton David J, Simmons Leo O, Perry Carole C, Wang X, Kaplan DL. Control of bioinspired silicification by genetically engineered fusion proteins: silk - silica binding peptides (SiBPs). Acta Biomaterialia. 2015;15:173-180 doi: 10.1016/j.actbio.2014.10.040. Epub 2014 Nov 4. PMID: ** PMCID: PMC** (SCI, IF: 6.025; Field-Weighted Citation Impact: 1.82; cited number: 7)
17.Li C, Luo T, Zheng Z, Murphy AR, Wang X^*, Kaplan DL. Curcumin-functionalized silk materials for enhancing adipogenic differentiation of bone marrow-derived human mesenchymal stem cells. Acta Biomaterialia. 2015;11:222-232 doi: 10.1016/j.actbio.2014.08.009. Epub 2014 Aug 15. PMID: ** PMCID: PMC** (SCI, IF: 6.025; Field-Weighted Citation Impact: 2.08; cited number: 10)
18.Yin Y, Huang P, Li D, Han Z, Wei G, Zhou C, Wen J, Su B, Wang Y, Wang X^*. Collagen nanofibers facilitated presynaptic maturation in differentiated neurons from spinal cord-derived neural stem cells through MAPK/ERK1/2- Synapsin I signaling pathway. Biomacromolecules. 2014;15:2449-2460 doi: 10.1021/bm500321h. Epub 2014 Jul 1. PMID: ** (SCI, IF: 5.75; Field-Weighted Citation Impact: 1.18; cited number: 8)
19.Leng X, Liu B, Su B, Liang M, Shi L, Li S, Qu S, Fu X, Liu Y, Yao M, Wang Y, Wang X^*, Kaplan DL. In Situ Ultrasound Imaging of Silk Hydrogel Degradation and Neovascularization. J Tissue Eng Regen Med. 2017;11:822-830; Med. doi: 10.1002/term.1981. Accession number: ** doi: 10.1002/term.1981. Epub 2015 Apr 5. PMID: ** (SCI, IF: 2.37; Field-Weighted Citation Impact: 0.74; cited number: 1)
20.Qing Liu, Shufa Zhou, Zeyu Zhao, Zhaozhu ZHENG, Gang Li, Xiaoqin Wang. SF/polyethylene Glycol nano-fibrous membranes loaded with Curcumin, Thermal Science 2017, 21(4), 21-27. (SCI, IF 0.95)
授权发明专利情况
1一种可注射丝素蛋白原位凝胶的制备方法及其应用ZL2.2发明授权2/3
2一种大分子量丝素蛋白冻干粉的制备工艺ZL5.7发明授权1/2
3一种家蚕丝素蛋白溶液制备及鉴定6.3发明实审1/2
4一种治疗内耳疾病的控释缓释丝素蛋白凝胶制剂3.1发明实审1/2
5 一种用于药物控释的丝素-载药纳微米颗粒的制备方法3.1发明实审1/4
6一种大分子量丝素蛋白冻干粉、制备工艺及其应用PCT/CN2015/075019发明实审1/7
7一种用聚乙二醇制备丝素纳微米球的方法及其在药物控释中的应用PCT/CN2015/097464发明实审1/3
8一种三维复合结构肛瘘线及其制备方法8.7发明实审5/5

9一种具有纬纱张力控制器的的织机梭子**实用新型授权5/5
10一种农药残留检测方法及检测试剂盒1.9发明实审2/3
11 一种利用丝素蛋白对DNA保存的方法及试剂盒20**发明实审1/2
12一种小口径圆纬机添纱装置2.5发明实审5/5
13一种制备医用管状支架的装置9.5发明实审7/7
联系方式
联系电话：E-Mail:wangxiaoqin@suda.edu.cn