导航
个人信息
科学研究
成果奖励
教学招生









个人简介
****，博士生导师

教育背景：
2002.9-2006.7湖北大学生命科学学院化学生物学基地班，学士学位
2006.9-2012.7中科院福建物质结构研究所生物化学与分子生物学专业，博士学位
博士生导师:黄明东教授
工作经历：
2018.05-至今苏州大学分子酶学研究所，****
2017.12-2018.04清华大学生命科学学院，助理研究员
合作导师:李雪明教授
2012.11-2017.10美国癌症研究所生物大分子晶体学实验室/阿贡国家实验室 博士后
博士后导师:Zbigniew Dauter



研究领域
1. 生物大分子的结构与功能研究
2. 蛋白质与核酸的相互作用研究
3. 晶体方法学的开发和应用




基本信息
罗智璞
职称： 教授
院部/部门： 医学部基础医学与生物科学学院
学历：
学位：
毕业学校： 中国科学院福建物质结构研究所
毕业专业：


联系方式
通讯地址：
邮政编码：
电子邮箱： luozhipu@suda.edu.cn
联系电话：
传真号码：
办公地点： 医学部




Copyright ? 2011-2014苏州大学版权所有苏州大学信息化建设与管理中心技术支持




科学研究


科研团队



Copyright ? 2011-2014苏州大学版权所有苏州大学信息化建设与管理中心技术支持




论文
已发表SCI论文31篇; 其中一作与共同一作15篇。

第一作者、共同第一作者(*)及通讯作者文章(#):
15. Heng, Z.,*Luo, Z.,*Li, X.M.# Using Focus Ion Beam to Prepare Crystal Lamella for Electron Diffraction. (2019) Journal of Structural Biology. https://doi.org/10.1016/j.jsb.2019.02.004.
14.Luo, Z.*, Dauter, Z.#Crystal structure of Z-DNA with untypically coordinated Ca2+ ions (2017) Journal of Biological Inorganic Chemistry, DOI: https://doi.org/10.1007/s00775-017-1526-4. (IF=2.894)
13.Luo, Z.*, Kelleher, A., Darwiche, R., Hudspeth, E., Shittu, O., Krishnavajhala, A., Schneiter, R., Lopez, J.#, and Asojo, O.#Crystal Structure of Borrelia turicatae protein, BTA121, a differentially regulated protein in the tick-mammalian transmission cycle of relapsing fever spirochetes. (2017) Scientific Reports, doi:10.1038/s41598-017-14959-9. (IF=4.259)
12.Luo, Z.*, Dauter, Z.#, Gilski, M. Four highly twinned structures of d(CGCGCG)2 extend the repertoire of pseudohexagonal crystal structures of Z-DNA. Acta Crystallographica Section D Biological Crystallography, 73, 940-951. (Cover paper) (IF=2.114)
11.Raroni, R.*,Luo, Z*., Darwiche, R., Hudspeth, E., Schneiter, R., Pereira, G., Mondego, J., Asojo, O.#(2017) Crystal Structure of MpPR-1i, a CAP protein from Moniliophthora perniciosa, the fungus that causes Witches' Broom Disease of Cacao. Scientific Reports, doi:10.1038/s41598-017-07887-1. (IF=4.259)
10.Luo, Z.*, Dauter, Z.#(2017) Embarras de richesses – it is not good to be too anomalous: accurate structure of selenourea, a chiral crystal of planar molecules. PLOS One, doi: 10.1371/journal.pone.**. (IF=2.806)
9.Shen, F.*,Luo, Z.*, Liu, H.,Wang, R.,Zhang, S., Gan, J., and Sheng, J.#(2017)Structural insights into RNA duplexes with multiple 2’-5’-linkages. Nucleic Acids Research,45(6):3537-3546. (IF=10.162)
8. Luo, Z.*, #(2016) Selenourea: a convenient phasing vehicle for macromolecular X-ray crystal structures. Scientific Reports, 6, 37123;doi: 10.1038/srep37123.(First and corresponding author, IF=4.259)
7. Wang, R.*,Luo, Z.*, He, K., Delaney, MO., Chen, D., Sheng, J.#(2016) Base pairing and structural insights into the 5-formylcytosine in RNA duplex. Nucleic Acids Research, 44(10): 4968-4977 (IF=10.162)
6.Luo, Z.*, Dauter, Z.#(2016) Detection of twinning in macromolecular crystallography, Zeitschrift fuer Kristallographie, 231(10): 561-571 (IF=3.179)
5.Luo, Z.*, Dauter, Z.#(2015) Flexibility of Terminal Cytidines in Ca2+ Form B-DNA, The FASEB Journal 29 (1 Supplement), 710.15 (IF=5.498)
4.Luo, Z.*, Dauter, M., Dauter, Z.#(2014) Phosphates in Z-DNA dodecamer are flexible, but their P-SAD signal is sufficient for structure solution, Acta Crystallographica Section D Biological Crystallography 70, 1790-1800. (IF=2.114)
3.Luo, Z.*, Raj, K., Dauter, Z.#(2014) Weak data do not make a free lunch, but only a cheap meal, Acta Crystallographica Section D Biological Crystallography 70, 253-260. (IF=2.114)
2.Luo, Z.*, Shi, X., Hu, Q., Zhao, B., and Huang, M.#(2012) Structural Evidence of Perfluorooctane Sulfonate Transport by Human Serum Albumin, Chemical Research in Toxicology 25, 990-992. (IF=3.278)
1.Wang, Y.*,Luo, Z.*, Shi, X., Wang, H., Nie, L., and Huang, M.#(2011) A fluorescent fatty acid probe, DAUDA, selectively displaces two myristates bound in human serum albumin, Protein science 20, 2095-2101. (IF=2.523）

其它共同作者文章:



16.Jiangqing Dong, Ximing Du, Huan Wang, Jue Wang, Chang Lu, Xiang Chen, Zhiwen Zhu,Zhipu Luo, Li Yu, Andrew J. Brown, Hongyuan Yang & Jia-Wei Wu (2019). Allosteric enhancement of ORP1-mediated cholesterol transport by PI(4,5)P2/PI(3,4)P2.Nature Communications. 10: 829
15.Liu, N., Zhang, J., Chen, Y., Liu, C., Zhang, X., Xu, K., Wen, J.,Luo, Z., Chen, S., Gao, P., Jia, K., Liu, Z., Peng, H., Wang, H. (2019) Bioactive functionalized monolayer graphene for high resolution cryo-EM.Journal of the American Chemical Society. Feb 6. doi: 10.1021/jacs.8b13038
14.Jiang, L., Zhang, X., Zhou, Y., Chen, Y.,Luo, Z., Li, J., Yuan, C., Huang, M. (2018) Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases. RSC Advances 8(49):28189-28197. (IF=2.936)
13.Li, Y., Zhao, C., Luo, F., Liu, Z., Gui, X.,Luo, Z., Zhang, X., Li, D., Liu, C., Li. X. (2018) Amyloid fibril structure of α-synuclein determined by cryo-electron microscopy. Cell Res. 28(9):897-903. (IF=15.606)
12.Liu, T., Liu, X., Wang, W.,Luo, Z., Liu, M., Zou, S., Sissa, C., Painelli, A., Zhang, Y., Vengris, M. and Bondar, M.V. (2018) Systematic Molecular Engineering of a Series of Aniline-Based Squaraine Dyes and Their Structure-Related Properties. The Journal of Physical Chemistry C. 122 (7), 3994-4008. (IF=4.484)
11.Zhang, Z., Li, H.,Luo, Z., Chang, S., Li, Z., Guan, M., Zhou, Z., Liu, M., Grossman, J., Ren, S. (2017) Molecular Assembly-Induced Charge Transfer for Programmable Functionalities,Chemistry of Materials29, 9851-9858
10.Yuan, C., Jürgensen, H.J., Engelholm, L.H., Li, R., Liu, M., Jiang, L.,Luo, Z., Behrendt, N. and Huang, M. (2016) Crystal structures of the ligand-binding region of uPARAP: effect of calcium ion binding.Biochem Journal. 473(15):2359-2368. (IF=3.797)
9.Xu, B.,Luo, Z., Wilson, AJ., Chen, K., Gao, W., Yuan, G., Chopra, HD., Chen, X., Willets, KA., Dauter, Z., Ren, S. (2016) Multifunctional Charge-Transfer Single Crystals through Supramolecular Assembly,Advanced Materials, 28(26): 5322–5329 (IF=19.791)
8.Xu, B.,Luo, Z., Gao, W., Wilson, A., He, C., Chen, C., Yuan, G., Dai, H., Rao, Y., Willets, K., Dauter, Z., Ren, S. (2016) Solution-Processed Molecular Opto-Ferroic Crystals,Chemistry of Materials28, 2441–2448 (IF=9.466)
7.Xu, P., Xu, M., Jiang, L., Yang, Q.,Luo, Z., Dauter, Z., Huang, M., Andreasen, P. (2015) Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold,Journal of Medicinal Chemistry58, 8868-8876. (IF=6.259)
6.Zhao, B., Gandhi, S., Yuan, C.,Luo, Z., Li, R., G?rdsvoll, H., de Lorenzi, V., Sidenius, N., Huang, M., Ploug. M.. (2015) Stabilizing a flexible interdomain hinge region harboring the SMB binding site drives uPAR into its closed conformation,Journal of Molecular Biology427, 1389-1403. (IF=4.632)
5.Wang, Y., Yu, H., Shi, X.,Luo, Z., Lin, D., Huang, M. (2013) Structural mechanism of ring-opening reaction of glucose by human serum albumin,Journal of biological Chemistry288, 15980-15987. (IF=4.125)
4.Liu, Y., Chen, M.,Luo, Z., Lin, J., Song L. (2013) Investigation on the site-selective binding of bovine serum albumin by erlotinib hydrochloride,Journal of Biomolecular Structure and Dynamics10, 1160-1174. (IF=3.123)
3.Li, L.,Luo, Z., Chen, Z., Chen, J., Zhou, S., Xu, P., Hu, P., Wang, J., Chen, N., Huang, J., Huang, M. (2012) Enhanced photodynamic efficacy of zinc phthalocyanine by conjugating to heptalysine,Bioconjugate Chemistry23, 2168-2172. (IF=4.818)
2.Lin, Z., Jiang, L., Yuan, C., Jensen, J. K., Zhang, X.,Luo, Z., Furie, B. C., Furie, B., Andreasen, P. A., and Huang, M. (2011) Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1,The Journal of Biological Chemistry286, 7027-7032. (IF=4.125)
1.Chen, Z., Zhou, S., Chen, J., Deng, Y.,Luo, Z., Chen, H., Hamblin, M. R., and Huang, M. (2010) Pentalysine beta-carbonylphthalocyanine zinc: an effective tumor-targeting photosensitizer for photodynamic therapy,ChemMedChem5, 890-898. (IF=3.225)



荣誉奖励




Copyright ? 2011-2014苏州大学版权所有苏州大学信息化建设与管理中心技术支持




开授课程


招生信息
1，博士生：医学细胞与分子生物学（1001Z2）
2，硕士生：生化与分子生物学（071010）




Copyright ? 2011-2014苏州大学版权所有苏州大学信息化建设与管理中心技术支持






科研成果（旧版）