彭睿
教授博士生导师


1996年获南京大学理学学士学位；
1999年获南京大学理学硕士学位；
2005年获美国范德比尔特大学（Vanderbilt University）分子生物学博士学位。
2008年10月加入苏州大学功能纳米与软物质研究院。


研究领域：
纳米生物学，分子生物学

研究方向：
纳米生物界面；纳米材料的生物学效应与调控；纳米材料的免疫学效应及应用；基于纳米载体的肿瘤免疫治疗

主要成果和技术贡献：
在多年分子细胞生物学研究的基础上，结合纳米技术，在纳米生物学领域开展了系统深入的研究，从对纳米生物界面的深入理解出发，研究纳米生物界面的精确设计与精细调控，揭示其对纳米材料生物学效应的调控机制；在此基础上，开发相应的生物医学应用。揭示了不同碳基纳米材料与多种蛋白质、真核细胞、原核生物之间的相互作用及分子作用机制，并据此开发出其在酶工程、抗菌、微生物工程等方面的新型应用。系统研究了多种纳米材料的免疫学效应，发展了多种新型纳米载体用于肿瘤免疫联合治疗。
学术论文40余篇，发表于ACS Nano, Nat. Commun., Adv. Mater., Adv. Drug Deliver. Rev., Small, Biomaterials, Nano Res., Nanoscale, ACS Appl. Mater. Inter., J. Biol. Chem., RNA等材料和生物领域的国际权威期刊。授权国家发明专利2项。承担NSFC面上、重点及重大研究计划培育项目、国家973项目、重点研发专项、教育部基金等7项。

近五年代表性论文：
1.Yonghui Wang, Jun Xu, Ligeng Xu, Xiaofang Tan, Liangzhu Feng, Yinchan Luo, Jian Liu, Zhuang Liu, Rui Peng*. Functionalized graphene oxide triggers cell cycle checkpoint control through both the ATM and the ATR signaling pathways, Carbon, 2017, doi: 10.1016/j.carbon.2017.12.012
2.Jun Xu, Ligeng Xu,* Chenya Wang, Rong Yang, Qi Zhuang, Xiao Han, Ziliang Dong, Wenwen Zhu, Rui Peng*, and Zhuang Liu*. Near-Infrared-Triggered photodynamic therapy with multi-tasking upconversion nanoparticles in combination with checkpoint blockade for immunotherapy of colorectal cancer. ACS Nano, 2017, 11, 4463?4474
3.Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng& Zhuang Liu*. Hollow MnO₂as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses. Nat. Commun., 2017, 8,902
4.Qian Chen,? Ligeng Xu,? Chao Liang, Chao Wang, Rui Peng& Zhuang Liu*. Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy. Nat. Commun., 2016, 7,13193
5.Ligeng Xu, Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng, Zhuang Liu* and Rui Peng*, Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity. Nanoscale, 2016, 8, 3785 (2016 Hot Articles in Nanoscale)
6.Yinchan Luo, Xinxing Yang, Xiaofang Tan, Ligeng Xu*, Zhuang Liu, Jie Xiao, Rui Peng*, Functionalized graphene oxide in microbial engineering: An effective stimulator for bacterial growth, Carbon, 2016, 13, 172-180
7.Ligeng Xu, Jian Xiang, Rui Peng*, Zhuang Liu.* Recent advances in the development of nanomaterials for DC-based immunotherapy. Sci. Bull., 2016, 61, 514-523
8.Jian Xiang, Ligeng Xu*, Hua Gong, Wenwen Zhu, Chao Wang, Jun Xu, Liangzhu Feng, Liang Cheng, Rui Peng*, and Zhuang Liu*, Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy. ACS Nano, 2015, 9, 6401?6411
9.Kai Yao, Pengli Tan, Yinchan Luo, Liangzhu Feng, Ligeng Xu, Zhuang Liu, Youyong Li*, and Rui Peng*, Graphene Oxide Selectively Enhances Thermostability of Trypsin. ACS Appl. Mater. Interfaces, 2015, 7, 12270?12277
10.Hua Gong, Jian Xiang, Ligeng Xu,* Xuejiao Song, Ziliang Dong, Rui Peng*and Zhuang Liu*, Stimulation of immune systems by conjugated polymers and their potential as an alternative vaccine adjuvant. Nanoscale, 2015,7, 19282-19292
11.Fei Tian, Guangcun Chen, Peiwei Yi, Jichao Zhang, Aiguo Li, Jing Zhang, Lirong Zheng, Zongwu Deng, Qin Shi*, Rui Peng*, and Qiangbin Wang*. Fates of Fe₃O₄and Fe₃O₄@SiO₂Nanoparticles in Human Mesenchymal Stem Cells Assessed by Synchroton Radiation-Based Techniques. Biomaterials, 2014, 35, 6412-6421
12.Chao Wang, Ligeng Xu, Chao Liang, Jian Xiang, Rui Peng, and Zhuang Liu*. Immunological Responses Triggered by Photothermal Therapy with Carbon Nanotubes in Combination with Anti-CTLA-4 Therapy to Inhibit Cancer Metastasis. Adv. Mater., 2014, 26, 8154?8162
13.Tengfei Tian, Xiaoze Shi, Liang Cheng, Yinchan Luo, Ziliang Dong, Hua Gong, Ligeng Xu, Zengtao Zhong, Rui Peng*, and Zhuang Liu*. Graphene-Based Nanocomposite As an Effective, Multifunctional, and Recyclable Antibacterial Agent. ACS Appl. Mater. Interfaces, 2014, 6, 8542?8548
14.Liming Qu, Jinhai Xu, Xiaofang Tan, Zhuang Liu, Ligeng Xu*, and Rui Peng*. Dual-Aptamer Modification Generates a Unique Interface for Highly Sensitive and Specific Electrochemical Detection of Tumor Cells. ACS Appl. Mater. Interfaces, 2014, 6, 7309-7315
15.Shuai Fang, Chao Wang, Jian Xiang, Liang Cheng, Xuejiao Song, Ligeng Xu, Rui Peng*, and Zhuang Liu*. Aptamer-conjugated upconversion nanoprobes assisted by magnetic separation for effective isolation and sensitive detection of circulating tumor cells. Nano Res., 2014, 7, 1327-1336
16.Yanfeng Zhou, Xiangxu Jiang, Jia Tang, Yuanyuan Su, Fei Peng, Yimei Lu, Rui Peng*, and Yao He*. A Silicon-Based Antibacterial Material of Robust and High Antibacterial Activity. J. Mater. Chem. B,2014, 2, 691-697
17.Ligeng Xu, Liang Cheng, Chao Wang, Rui Peng*, and Zhuang Liu*. Conjugated polymers for photothermal therapy of cancer. Polym. Chem., 2014, 5, 1573-1580 (2014's most accessed Polymer Chemistry Top10 articles) （邀请综述）
18.Hua Gong, Rui Peng*, Zhuang Liu*, Carbon nanotubes for biomedical imaging: The recent advances. Adv. Drug Deliver. Rev.2013, 65, 1951-63 （邀请综述）
19.Kai Yang, Yingjie Li, Xiaofang Tan, Rui Peng*and Zhuang Liu*, Behavior and Toxicity of Graphene and Its Functionalized Derivatives in Biological Systems. Small, 2013, 9: 1492-1503
20.Liangzhu Feng, Xianzhu Yang, Xiaozhe Shi, Xiaofang Tan, Rui Peng, Jun Wang*, Zhuang Liu*, Polyethylene Glycol and Polyethylenimine Dual-Functionalized Nano-Graphene Oxide for Photothermally Enhanced Gene Delivery. Small, 2013, 9, 1989-1997
21.Jia Tang, Qian Chen, Ligeng Xu, Shuai Zhang, Liangzhu Feng, Liang Cheng, Huan Xu, Zhuang Liu* and Rui Peng*, Graphene oxide-silver nanocomposite as a highly effective antibacterial agent with species-specific mechanisms. ACS Appl. Mater. Interfaces, 2013, 5, 3867?3874
22.Xiaofang Tan, Liangzhu Feng, Jing Zhang, Kai Yang, Shuai Zhang, Zhuang Liu* and Rui Peng*. Functionalization of Graphene Oxide Generates a Unique Interface for Selective Serum Protein Interactions. ACS Appl. Mater. Interfaces, 2013, 5, 1370?1377
23.Jing Zhang, Liangzhu Feng, Xiaofang Tan, Xiaozhe Shi, Ligeng Xu, Zhuang Liu* and Rui Peng*, Dual-Polymer-Functionalized Nanoscale Graphene Oxide as a Highly Effective Gene Transfection Agent for Insect Cells with Cell-Type-Dependent Cellular Uptake Mechanisms,Part. & Part. Syst. Char., 2013, 30, 794?803.
24.Liling Jin, Kai Yang, Kai Yao, Shuai Zhang, Huiquan Tao, Shuit-Tong Lee, Zhuang Liu* and Rui Peng*. Functionalized Graphene Oxide in Enzyme Engineering: A Selective Modulator for Enzyme Activity and Thermostability. ACS Nano, 2012, 6, 4864?4875 (Nanowerk亮点报道)


联系电话：
E-mail: rpeng@suda.edu.cn

责任编辑：杨娟