殷黎晨
教授博士生导师

2005年7月获复旦大学生物科学专业学士学位；2010年7月获复旦大学生物化学与分子生物学专业博士学位。2010年11月至2014年1月在美国伊利诺伊大学香槟分校（UIUC）材料科学与工程系从事博士后研究工作。2014年1月加盟苏州大学功能纳米与软物质研究院，被聘为****、博士生导师。

邮箱：lcyin@suda.edu.cn
电话：
个人介绍：
主要从事生物医用高分子和药物递送系统的开发并研究其在肿瘤、炎症、自身免疫性疾病治疗中的应用。共发表SCI论文100余篇（第一作者、通讯作者论文70余篇，影响因子大于10的论文28篇），他引5000余次，H因子38，7篇论文入选ESI高被引论文。获中国发明专利6项，美国专利2项。为欧美权威教材《Biomaterials Science》第四版撰写章节“Nanoparticles”。应邀担任第258届美国化学会年会分会场共同主席，Adv Drug Deliver Rev客座编辑。获国家优秀青年科学基金资助，入选“江苏省****”（重点资助）、江苏省“双创人才”。主持国家重点研发计划课题1项、国家自然科学基金4项。担任Nat Commun、Sci Adv、JACS、Adv Mater、Adv Funct Mater、ACS Nano等20余个期刊的独立审稿人。
研究方向：
（1）聚氨基酸生物材料：研究可用于药物载体、基因载体、免疫调节剂的聚氨基酸的合成与功能化修饰，探讨聚氨基酸的二级结构效应和调控方式。
（2）智能化药物递送系统：研究可改善蛋白质、多肽、核酸、小分子化学药物、气体分子等功效的新型给药载体的加工、改性、组装、体内外作用机理及其给药系统的设计。
（3）抗炎治疗与抗肿瘤治疗：根据疾病的发病机制及病灶部位的生理特点，设计新型纳米药物调控肿瘤、炎症等免疫微环境，用于肿瘤、炎症（如肝炎、胰腺炎、心肌梗死、急性肺损伤、脑卒中、骨性关节炎等）、自身免疫性疾病（如溃疡性结肠炎、类风湿性关节炎、系统性红斑狼疮等）的治疗。
招生方向：
本课题组热忱欢迎有志从事科研工作的本科生、硕士研究生和博士研究生加盟。本课题组的研究为交叉学科，招生方向包括“化学”、“生物学”以及“材料学”，欢迎具有化学、材料或生物背景的同学报考。如有咨询，请联系lcyin@suda.edu.cn。
招聘信息：
博士后：拟招收3-5名从事高分子生物材料合成、纳米药物设计、基因药物递送研究的博士后研究人员，要求能够独立开展研究工作，具有良好的英文写作与交流能力；易于沟通，可以协助指导研究生。具有高分子化学、有机化学、生物材料或药剂学背景的申请者优先考虑。待遇优厚，且有机会到国外交流访学。如有兴趣，请联系lcyin@suda.edu.cn。
讲师/副教授：拟招聘1-2名课题组讲师/副教授，要求获得（或即将获得）博士学位，具有高分子化学、生物材料或药剂学背景，在主流期刊上发表过SCI论文，能够独立开展研究并指导研究生。有意向者请发送简历和三位推荐人信息至lcyin@suda.edu.cn。
近五年代表性论文（*为通讯作者，^#为共同第一作者）：
1.Xudong Li^#, Yuansong Wei^#, Yuchen Wu,Lichen Yin*. Hypoxia-instructed pro-protein therapy assisted with self-catalyzed nanozymogen.Angew Chem Int Ed, 2020, doi:10.1002/anie..
2.Shixian Lv, Hojun Kim, Ziyuan Song, Feng Lin, Yingfeng Yang, Ryan Baumgartner, Kuan-Ying Tseng, Shen J. Dillon, Cecilia Leal,Lichen Yin*, Jianjun Cheng*. Unimolecular polypeptide micelles via ultra-fast polymerization ofN-carboxyanhydrides.J Am Chem Soc, 2020, 142, 8570-8574.
3.Chenglong Ge^#, Jiandong Yang^#, Shanzhou Duan, Yong Liu, Fenghua Meng,Lichen Yin*. Fluorinated α-helical polypeptides synchronize mucus permeation and cell penetration toward highly efficient pulmonary siRNA delivery against acute lung injury.Nano Lett, 2020, 20, 1738?1746.
4.Jing Yan, Qinghua Wu, Ziyin Zhao, Jianhua Wu, Huan Ye, Qiujun Liang, Zhuchao Zhou*, Mengying Hou, Xudong Li, Yong Liu*,Lichen Yin*. Light-assisted hierarchical intratumoral penetration and programmed antitumor therapy based on tumor microenvironment (TME)-amendatory and self-adaptive polymeric nanoclusters.Biomaterials, 2020, 255, 120166.
5.Jing Yan, Rongying Zhu, Fan Wu, Ziyin Zhao, Huan Ye, Mengying Hou, Yong Liu*,Lichen Yin*. iRGD-Reinforced, Photo-Transformable Nanoclusters Toward Cooperative Enhancement of Intratumoral Penetration and Antitumor Efficacy.Nano Res, 2020, 13, 2706-2715.
6.Xiao Wang^#, Qiujun Liang^#, Yiming Mao, Rujing Zhang, Qiurong Deng, Yongbing Chen*, Rongying Zhu, Shanzhou Duan,Lichen Yin*. Bioreducible, branched poly(β-amino ester)s mediate anti-inflammatory ICAM-1 siRNA delivery against myocardial ischemia reperfusion (IR) injury.Biomater Sci, 2020, 8, 3856-3870.
7.Yongjuan Li, Juanjuan Dang, Qiujun Liang,Lichen Yin*. Thermal-responsive carbon monoxide (CO) delivery expedites metabolic exhaustion of cancer cells toward reversal of chemotherapy resistance.ACS Cent Sci, 2019, 5, 1044?1058.
8.Yongjuan Li^#, Juanjuan Dang^#, Qiujun Liang,Lichen Yin*. Carbon monoxide (CO)-strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction.Biomaterials, 2019, 209, 138-151.
9.Juanjuan Dang, Huan Ye, Yongjuan Li, Qiujun Liang, Xudong Li,Lichen Yin*. Multivalency-assisted membrane-penetrating siRNA delivery sensitizes photothermal ablation via inhibition of tumor glycolysis metabolism.Biomaterials, 2019, 223, 119463.
10.Yongjuan Li, Jian Hu, Xun Liu, Yong Liu*, Shixian Lv, Juanjuan Dang, Yong Ji*, Jinlin He,Lichen Yin*. Photodynamic therapy-triggered on-demand drug release from ROS-responsive core-cross-linked micelles toward synergistic anti-cancer treatment.Nano Res, 2019, 12, 999-1008.
11.Xin Xu^#, Weijing Yang^#, Qiujun Liang, Yanan Shi, Wenxin Zhang, Xiao Wang, Fenghua Meng, Zhiyuan Zhong*,Lichen Yin*. Efficient and Targeted Drug/siRNA Co-Delivery Mediated by Reversibly Crosslinked Polymersomes toward Anti-Inflammatory Treatment of Ulcerative Colitis (UC).Nano Res, 2019, 12, 659-667.
12.Jinhui Wang^#, Hua He^#, Xin Xu, Xiao Wang, Yongbing Chen,Lichen Yin*. Far-Red Light-Mediated Programmable Anti-Cancer Gene Delivery in Cooperation with Photodynamic Therapy.Biomaterials, 2018, 171, 72-82.
13.Shixian Lv, Yuchen Wu, Kaimin Cai, Hua He, Yongjuan Li,Min Lan, Xuesi Chen, Jianjun Cheng,Lichen Yin*. High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor?Receptor Coordination Interactions.J Am Chem Soc, 2018, 140, 1235?1238.
14.Hong-Xia Wang, Ziyuan Song, Yeh-Hsing Lao, Xin Xu, Jing Gong, Du Cheng, Syandan Chakraborty, Mingqiang Li, Dangtong Huang,Lichen Yin*, Jianjun Cheng*, Kam W. Leong*. Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide.Proc Natl Acad Sci USA, 2018, 115, 4903-4908.
15.Hua He^#, Yongbing Chen^#, Yongjuan Li^#, Ziyuan Song, Yinan Zhong, Rongying Zhu, Jianjun Cheng*,Lichen Yin*. Effective and Selective Anti-Cancer Protein Delivery via All-Function-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering.Adv Funct Mater,2018, 28, **.
16.Hua Wang^#, Ruibo Wang^#, Kaimin Cai^#, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen*,Lichen Yin*, Jianjun Cheng*. Selective in vivo metabolic cell-labeling-mediated cancer targeting.Nat Chem Biol, 2017, 13, 415-424.
17.Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson*,Lichen Yin*, Jianjun Cheng*. Modulation of polypeptide conformation through donor–acceptor transformation of side-chain hydrogen bonding ligands.Nat Commun, 2017, 8:92.
18.Menghua Xiong^#, Yan Bao^#, Xin Xu^#, Hua Wang, Zhiyuan Han, Zhiyu Wang, Yeqing Liu, Songyin Huang, Ziyuan Song, Jinjing Chen, Richard M. Peek,Lichen Yin*, Lin-Feng Chen*, Jianjun Cheng*. Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides.Proc Natl Acad Sci USA, 2017, 114, 12675-12680.
19.Menghua Xiong, Zhiyuan Han, Ziyuan Song, Jin Yu, Hanze Ying,Lichen Yin*, Jianjun Cheng*. Bacteria-Assisted Activation of Antimicrobial Polypeptides by a Random-Coil to Helix Transition.Angew Chem Int Ed,2017, 56, 10826-10829.
20.Hua He, Nan Zheng, Ziyuan Song, Kyung Hoon Kim, Catherine Yao, Rujing Zhang, Chenglin Zhang, Yuhui Huang, Fatih M. Uckun, Jianjun Cheng, Yanfeng Zhang,Lichen Yin*. Suppression of Hepatic Inflammation via Systemic siRNA Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide Hybrid Nanoparticles.ACS Nano, 2016, 10, 1859?1870.
文章完整列表：https://scholar.google.com/citations?user=66CEhX8AAAAJ&hl=zh-CN

责任编辑：杨娟